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个人简介

1、学历背景: 2002.9-2006.6 浙江大学药学院,药学,理学学士 2006.9-2011.6 浙江大学药学院,药理学,博士 2、国外学习研究经历: 2008.1-2009.7美国University of Southern California,访问学者 3、工作经历: 2011.7-2013.12 浙江大学药学院,肿瘤药理学,助理研究员/博士后 2014.1-2017.11 浙江大学药学院,肿瘤药理学,副教授 2017.12-至今浙江大学药学院,肿瘤药理学,教授

研究领域

(1)基于儿童肿瘤的创新药物靶点发现研究 (2)基于靶点的抗肿瘤创新药物研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1)Qian Zhou#, Miao Xian#, Senfeng Xiang, Danyan Xiang, Xuejing Shao, Jincheng Wang, Ji Cao, Xiaochun Yang, Bo Yang, Meidan Ying(应美丹)* and Qiaojun He*. All-trans retinoic acid prevents osteosarcoma metastasis by inhibiting M2 polarization of tumor-associated macrophages. Cancer Immunology Research. 2017 Jul;5(7):547-559. 2)Yangling Li, Miao Xian, Bo Yang, Meidan Ying(应美丹)* and Qiaojun He*. Inhibition of KLF4 by statins reverses Adriamycin-induced metastasis and cancer stemness in osteosarcoma cells. Stem cell reports. 2017.June 6. 8 (6):1617-1629. 3)Meidan Ying(应美丹), Lei Zhang, Qian Zhou, Xuejing Shao, Ji Cao, Ning Zhang, Weixu Li, Hong Zhu, Bo Yang*, Qiaojun He*. The E3 Ubiquitin Protein Ligase MDM2 Dictates All-Trans Retinoic Acid induced Osteoblastic Differentiation of Osteosarcoma cells by Modulating the Degradation of RARα. Oncogene, 2016 Aug 18;35(33):4358-67. 4)Miao Xian #, Handi Cao #, Ji Cao, Xuejing Shao, Difeng Zhu, Ning Zhang, Ping Huang,Weixu Li, Bo Yang, Meidan Ying(应美丹)* and Qiaojun He*. Bortezomib sensitizes human osteosarcoma cells to adriamycin-induced apoptosis through ROS-dependent activation of p-eIF2α/ATF4/CHOP axis. International Journal of Cancer. 2017 Sep 1;141(5):1029-1041. 5)Xuejing Shao #, Yujia Liu #, Yangling Li , Miao Xian , Qian Zhou , Bo Yang , Meidan Ying(应美丹)* and Qiaojun He*. The HER2 inhibitor TAK165 Sensitizes Human Acute Myeloid Leukemia Cells to Retinoic Acid-Induced Myeloid Differentiation by activating MEK/ERK mediated RARα/STAT1 axis. Scientific Reports. 2016; 6: 24589. 6)Nan Xie#, Like Zhong#, Lu Liu, Yanfeng Fang, Xiaotian Qi, Ji Cao, Bo Yang, Qiaojun He, and Meidan Ying(应美丹)*. Autophagy contributes to dasatinib-induced myeloid differentiation of human acute myeloid leukemia cells. Biochemical Pharmacology. 2014 May.89(1):74-85. 7)Qian Zhou#, Lei Zhang#, Zibo Chen, Pingge Zhao, Yaxi Ma, Bo Yang, Qiaojun He, Meidan Ying(应美丹) *. Small ubiquitin-related modifier-1 modification regulates all-trans-retinoic acid-induced differentiation via stabilization of retinoic acid receptor . FEBS J. 2014 Jul;281(13):3032-47. 8)Meidan Ying(应美丹), Gang Liu, Hiroyuki Shimada, Wanjing Ding, William A. May, Qiaojun He, G B Adams and Lingtao Wu*. Human osteosarcoma CD49f-CD133+ cells: impaired in osteogenic fate while gain of tumorigenicity. Oncogene. 2013. 32(36):4252-4263 9)Meidan Ying(应美丹)#, Xinglu Zhou#, Like Zhong, Nengming Lin, Hui Jing, Peihua Luo, Xiaochun Yang, Hua Song, Bo Yang*, Qiaojun He*. Bortezomib Sensitizes Human Acute Myeloid Leukemia Cells to All-Trans-Retinoic Acid-induced Differentiation by modifying the RAR/STAT1 axis. Molecular Cancer Therapeutics.2013.12:195. 10)Siyue Lou, Like Zhong, Xiaochun Yang, Tao Xue, Renhua Gai, Difeng Zhu, Yuqin Zhao, Bo Yang, Meidan Ying(应美丹)*, Qiaojun He*. Efficacy of all-trans retinoid acid in preventing nickel induced cardiotoxicity in myocardial cells of rats. Food and Chemical Toxicology. 2013 (51) 251–58.

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