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个人简介

浙江大学药学院教授,博士生导师,兼任教育部药学类教指委制药工程专业分委会委员、中华中医药学会中医药信息学分会副秘书长、浙江省药学会理事及中药与天然药物专委会副主任委员。本科毕业于浙江大学制药工程专业,博士毕业于浙江大学药物分析学专业,获全国优秀博士学位论文提名奖及浙江省优秀博士论文。先后在FDA国立毒理研究中心、哈佛大学医学院从事访问研究,主要开展药物组合物筛选、中药药效物质及现代中药设计方法学研究。在Adv. Sci., Anal. Chem., Pharmacol. Res., Chem. Comm.等杂志发表SCI收录论文70余篇。先后承担国家重点研发计划课题、国家科技重大专项子课题、国家973计划子课题、国家自然科学基金等国家级课题10余项,获国家科技进步一等奖1项,省部级科技进步奖励5项,授权发明专利22项,计算机软件著作权2项,获国家优秀青年科学基金、浙江省杰出青年科学基金资助,入选浙江省“151”人才计划。

研究领域

中药药效物质 高内涵药物筛选 现代中药创制与大品种二次开发

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Dejin Xun, Deheng Chen, Yitian Zhou, Volker M. Lauschke, Rui Wang*, Yi Wang*. Scellseg: a style-aware cell instance segmentation tool with pre-training and contrastive fine-tuning [J]. iScience, 2022, 25(12):105506. Yufei Li, Hongda Sheng, Ziwei Yan, Bin Guan, Shifa Qiang, Jing Qian*, Yi Wang*. Bilirubin stabilizes the mitochondrial membranes during NLRP3 inflammasome activation [J]. Biochemical Pharmacology, 2022, 203: 115204. Bo Fan, Yingchao Wang, Zhenhao Li, Dejin Xun, Jian Dong, Xiangwei Zhao, Xiaohui Fan*, Yi Wang*. Si@Ag@PEI Substrate-based SERS Sensor for Rapid Detection of Illegally Adulterated Sulfur Dioxide in Traditional Chinese Medicine [J]. Talanta, 2022, 238:122988. Chen J, Wang Y, Wang S, Zhao X, Zhao L *, Wang Y*. Salvianolic acid B and ferulic acid synergistically promote angiogenesis in HUVECs and zebrafish via regulating VEGF signaling [J]. Journal of Ethnopharmacology, 2022, 283: 114667. Lu Zhao#, Hao Liu#, Yingchao Wang, Shufang Wang, Dejin Xun, Yi Wang*, Yiyu Cheng*, Boli Zhang. Multimodal Identification by Transcriptomics and Multiscale Bioassays of Active Components in Xuanfeibaidu Formula to Suppress Macrophage-Mediated Immune Response, Engineering, 2022. Shujing Zhang, Yingchao Wang, Min Yu, Ye Shang, Yanxu Chang, Hong Zhao, Yu Kang, Lu Zhao, Lei Xu, Xiaoping Zhao*, Dario Difrancesco, Mirko Baruscotti, Yi Wang*. Discovery of herbacetin as a novel SGK1 inhibitor to alleviate myocardial hypertrophy [J]. Advanced Science, 2022,9, 2101485. Yunru Yu#, Jing Chen#, Xiaohui Zhang, Yingchao Wang, Shufang Wang, Lu Zhao*, Yi Wang*. Identification of anti-inflammatory compounds from Zhongjing formulae by knowledge mining and high-content screening in a zebrafish model of inflammatory bowel diseases [J]. Chinese Medicine, 2021, 16:42. Xiaohui Zhang#, Yule Wang#, Kai Zhang, Hongda Sheng, Yuhan Wu, Huimin Wu, Yingchao Wang, Jianli Guan, Qingfen Meng, Huahuan Li, Zhenhao Li, Guanwei Fan*,Yi Wang*. Discovery of tetrahydropalmatine and protopine regulate the expression of dopamine receptor D2 to alleviate migraine from Yuanhu Zhitong formula [J]. Phytomedicine, 91 (2021) 153702. Xuechun Chen, Dejin Xun, Ruzhang Zheng, Lu Zhao, Yuqing Lu, Jun Huang, Rui Wang*, Yi Wang*, Deep-learning-assisted assessment of DNA damage based on Foci images and its application in high-content screening of lead compounds, Analytical Chemistry, 2020,92(20):14267-14277. YinchuanXu#, Shujing Zhang#, Jiabing Rong#, Yao Lin, Linlin Du, Yi Wang*, Zhaocai Zhang*. Sirt3 is a novel target to treat sepsis induced myocardial dysfunction by acetylated modulation of critical enzymes within cardiac tricarboxylic acid cycle, Pharmacological Research, 2020, 159, 104887. Jian Sheng, Qingfen Meng, Zhenzhong Yang, Jianli Guan, Yu Zhao, Jide Zhang, Yingchao Wang, Lu Zhao*, Yi Wang*. Identification of cryptotanshinone from Tongmai to inhibit thrombosis in zebrafish via regulating oxidative stress and coagulation cascade, Phytomedicine, 2020, 76, 153263. Yu Zhao, Jiawen Zou, Yanyan Song, Jun Peng, Yi Wang*, Yong Bi*. A novel label-free fluorescence assay for dipeptidyl peptidase 4 activity detection based on supramolecular self-assembly, Chemical Communications, 2020, 56, 1629-1632. (Inner Cover). Rui Guo, Lingning Liu, Hao Liu, Junhua Zhang, Han Zhang, Yingchao Wang, Mirko Baruscotti, Lu Zhao, Yi Wang*. High content screening identifies licoisoflavone A as a bioactive compound of Tongmaiyangxin Pills to restrain cardiomyocyte hypertrophy via activating Sirt3, Phytomedicine, 2020, 68: 153171. uifang Chen, Qian Jiang, Yu Qiu, Xuechun Chen, Bo Fan, Yi Wang*, Dongning Wang*, Hollow-Core-Photonic-Crystal-Fiber-Based Miniaturized Sensor for the Detection of Aggregation-Induced-Emission Molecules, Analytical Chemistry, 2019, 91, 780−784. Yi Wang, Yu Zhao, Wei Jiang, Xiaoping Zhao*, Guanwei Fan, Han Zhang, Peiqiang Shen, Jiangmin He, Xiaohui Fan*. iTRAQ-Based Proteomic Analysis Reveals Recovery of Impaired Mitochondrial Function in Ischemic Myocardium by Shenmai Formula, J Proteome Research, 2018, 17(2):794-803. Yi Wang*, Xueli Wu, Yiyu Cheng, Xiaoping Zhao*. Fluorescent switchable AIE probe for selective imaging of dipeptidyl peptidase-4 in vitro and in vivo and its application in screening DPP-4 inhibitors. Chemical Communications, 2016, 52, 3478 - 3481 (Back Cover) Yi Wang*, Yaqi Chen, Haibo Wang, Yiyu Cheng, Xiaoping Zhao*. Specific Turn-On Fluorescent Probe with Aggregation-Induced Emission Characteristics for SIRT1 Modulator Screening and Living-Cell Imaging. Analytical Chemistry, 2015, 87 (10), 5046–5049.

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