个人简介
2013~现在,浙江大学,教授,博士生导师 2007~2013,浙江大学,副教授 2008~2011,美国University of Texas M.D. Anderson Cancer Center 2005~2007,浙江大学,师资博士后 2000~2005,沈阳药科大学,药学博士
研究领域
1)高端药物制剂基础研究:揭示药物制剂体内作用机制、生物学行为、药效评价等 纳米药物及其给药系统 缓控式制剂 长效微球制剂
2)药物制剂的临床转化应用研究 探索药物制剂从基础研究到产业化的关键核心技术,尤其是纳米药物的临床转化
3)药物靶向治疗的设计与应用 研究药物靶向治疗的合理化设计和机理机制探索
4)癌症免疫治疗研究 采用药物制剂手段实现癌症的免疫治疗优化,以及实现多重治疗的结合
5)癌症光热治疗 以金纳米材料为基础的肿瘤显影技术研究,药物传递研究和靶向肿瘤的光热治疗研究
近期论文
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1. Xiaomeng Guo, Jiaxin Qu, Wei Li, Lihua Luo, Chunqi Zhu, Jie Yang, Xiaoyi Yin, Qingpo Li, Yongzhong Du, Dawei Chen, Jian You*. Synchronous delivery of oxygen and photosensitizer for alleviation of hypoxia tumor microenvironment and dramatically enhanced photodynamic therapy. Drug Delivery, 2018, 25. 585-599. (IF: 6.402)
2. Lihua Luo, Chunqi Zhu, Jie Yang, XiaomengGuo, Wei Li, Xiaoyi Yin, Mengshi Jiang, Bing Qin, Xiaoling Yuan, Hang Yin, Qingpo Li, Yongzhong Du, Jian You*, Sustained Release of Anti-PD-1 Peptide for Perdurable Immunotherapy Together with Photothermal Ablation against Primary and Distant Tumors. J Control Release, 2018 In press.(IF: 7.786)
3. Chunqi Zhu, Hanbo Zhang, Wei Li, Lihua Luo, Xiaomeng Guo, Zuhua Wang, Fenfen Kong, Qingpo Li, Jie Yang, Yongzhong Du, Jian You*. Suppress orthotopic colon cancer and its metastasis through exact targeting and highly selective drug release by a smart nanomicelle. Biomaterials, 2018, 161, 144-153.(IF: 8.402)
4. Wei Li, Wanqing Hou, Xiaomeng Guo, Lihua Luo, Qingpo Li, Chunqi Zhu, Jie Yang, Jiang Zhu, Yongzhong Du, Jian You. A temperature-controlled and phase-transition ultrasound imaging-guided photothermal-chemotherapy triggered by NIR light. Theranostics, 2018, In press. (IF=8.766)
5. Qingpo Li, Wei Li, Haixiao Di, Lihua Luo, Chunqi Zhu, Jie Yang, Xiaoyi Yin, Hang yin, Jianqing Gao, Yongzhong Du, Jian You*. A photosensitive liposome with NIR light triggered doxorubicin release as a combined photodynamic-chemo therapy system. J Control Release, 2018, 277, 114-125. (IF=7.786)