个人简介

Professor, Born 1962; B.S., University of Virginia (1984); Ph.D., Cornell University (1990); National Science Foundation Postdoctoral Fellowship, Stanford University, (1989-1991); National Science Foundation Young Investigator Award (1992); Arnold and Mabel Beckman Foundation Young Investigator (1992); Analytical Chemists of Pittsburgh Award (1992); Exxon Education Foundation Research Award (1993); American Society for Mass Spectrometry Research Award (1994); Alexander von Humboldt Senior Scientist Award (1999); Amgen Faculty Award (2004); Visiting Professor, Department of Physics and Astronomy, University of Aarhus, Denmark (2005); Faculty Scientist, Earth Sciences Division, Lawrence Berkeley National Laboratory; Faculty Director, QB3/Chemistry Mass Spectrometry Center, University of California, Berkeley; Associate Director, Center for Analytical Biotechnology, University of California, Berkeley; Member: ACS, ASMS.

研究领域

Professor Williams' research group is developing and applying novel instrumental and computational techniques in mass spectrometry, tandem mass spectrometry, separations, and laser spectroscopy to solve problems of fundamental interest in chemistry and biochemistry. Current projects are focused in three areas; 1) elucidating the structures, functions, and dynamics of biomolecules and their macromolecular complexes with emphasis on protein sequencing, conformational elucidation, and protein-protein interactions, 2) understanding ion solvation, how water organizes around different ions and how water affects molecular structure and intermolecular interactions. Competitive interactions between ions, water, and biomolecules of interest are investigated by probing ions in size-selected trapped nanodrops using spectroscopy and ion-electron recombination experiments and 3) developing new instrumentation to analyze complex mixtures, including contents of cells, using microfabricated devices coupled with mass spectrometry and developing probes for rapid chemical analysis of surfaces with high sensitivity. A number of different types of state-of-the-art mass spectrometers and lasers are used in these studies.

Professor Williams' research group is developing and applying novel instrumental and computational techniques in mass spectrometry, tandem mass spectrometry, separations, and laser spectroscopy to solve problems of fundamental interest in chemistry and biochemistry. Current projects are focused in three areas; 1) elucidating the structures, functions, and dynamics of biomolecules and their macromolecular complexes with emphasis on protein sequencing, conformational elucidation, and protein-protein interactions, 2) understanding ion solvation, how water organizes around different ions and how water affects molecular structure and intermolecular interactions. Competitive interactions between ions, water, and biomolecules of interest are investigated by probing ions in size-selected trapped nanodrops using spectroscopy and ion-electron recombination experiments and 3) developing new instrumentation to analyze complex mixtures, including contents of cells, using microfabricated devices coupled with mass spectrometry and developing probes for rapid chemical analysis of surfaces with high sensitivity. A number of different types of state-of-the-art mass spectrometers and lasers are used in these studies.

近期论文

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Elliott, A. G.; Merenbloom, S. I.; Chakrabarty, S.; Williams, E. R. Single Particle Analyzer of Mass: A Charge Detection Mass Spectrometer with a Multi-Detector Electrostatic Ion Trap Int. J. Mass Spectrom. 2017, Online Early Access. [Web] DiTucci, M. J.; Böhm, F.; Schwaab, G.; Williams, E. R.; Havenith, M. Effects of Multivalent Hexacyanoferrates and Their Ion Pairs on Water Molecule Dynamics Measured with Terahertz Spectroscopy Phys. Chem. Chem. Phys. 2017, Online Early Access. [Web] Susa, A. C.; Xia, Z.; Williams, E. R. Small Emitter Tips for Native Mass Spectrometry of Proteins and Protein Complexes from Nonvolatile Buffers That Mimic the Intracellular Environment Anal. Chem. 2017, Online Early Access. [Web] Heiles, S.; Cooper, R. J.; DiTucci, M. J.; Williams, E. R. Sequential Water Molecule Binding Enthalpies for Aqueous Nanodrops Containing a Mono-, Di- or Trivalent Ion and Between 20 and 500 Water Molecules Chem. Sci. 2017, , Online Early Access. [Web] Susa, A. C.; Xia, Z.; Tang, H. Y. H.; Tainer, J. A.; Williams, E. R. Charging of Proteins in Native Mass Spectrometry J. Am. Soc. Mass Spectrom. 2017, 28 332–340. [Web] DiTucci, M. J. and Williams, E. R. Nanometer Patterning of Water by Tetraanionic Ferrocyanide Stabilized in Aqueous Nanodrops Chem. Sci. 2017, 81391–1399. [Web] Mortensen, D. N.; Williams, E. R. Surface-Induced Protein Unfolding in Submicron Electrospray Emitters Anal. Chem. 2016, 88, 96628–9668. [Web] Mortensen, D. N.; Williams, E. R. Electrothermal Supercharging of Proteins in Native MS: Effects of Protein Isoelectric Point, Buffer, and NanoESI-Emitter Tip Size Analyst 2016, 141, 5598–5606. [Web] Mortensen, D. N.; Williams, E. R. Microsecond and Nanosecond Polyproline II Helix Formation in Aqueous Nanodrops Measured by Mass Spectrometry Chem. Comm. 2016, 52, 12218–12221. [Web] Bhattacharyya, M.; Stratton, M. M.; Going, C. C.; McSpadden, E. D.; Huang, Y.; Susa, A. C.; Elleman, A.; Cao, Y. M.; Pappireddi, N.; Burkhardt, P.; Gee, C. L.; Barros, T.; Schulman, H.; Williams, E. R.; Kuriyan, J. Molecular Mechanism of Activation-Triggered Subunit Exchange in Ca2+/Calmodulin-Dependent Protein Kinase II eLife 2016, 5, 13405. [Web] Going, C. C.; Xia, Z.; Williams, E. R. Real-time HD Exchange Kinetics of Proteins from Buffered Aqueous Solution with Electrothermal Supercharging and Top-Down Tandem Mass Spectrometry J. Am. Soc. Mass Spectrom. 2016, Online Early Access. [Web] Mortensen, D. N.; Williams, E. R. Ultrafast (1 µs) Mixing and Fast Protein Folding in Nanodrops Monitored by Mass Spectrometry J. Am. Chem. Soc. 2016, 138, 3453–3460. [Web] [Featured in C&EN Magazine] Cooper, R. J.; DiTucci, M. J.; Chang, T. M.; Williams, E. R. Delayed Onset of Crystallinity in Ion-Containing Aqueous Nanodrops J. Am. Chem. Soc. 2016, 138, 96–99. [Web] Masson, A.; Williams, E. R.; Rizzo, T. R. Molecular Hydrogen Messengers Can Lead to Structural Infidelity: A Cautionary Tale of Protonated Glycine J. Chem. Phys. 2015, 143, 104313. [Web] Heiles, S.; Cooper, R. J.; Berden, G.; Oomens, J.; Williams, E. R. Hydrogen Bond Mediated Stabilization of the Salt Bridge Structure for the Glycine Dimer Anion Phys. Chem. Chem. Phys. 2015, 17, 30642. [Web] Going, C. C.; Xia, Z.; Williams, E. R. New Supercharging Reagents Produce Highly Charged Protein Ions in Native Mass Spectrometry Analyst 2015, 140, 7184–7194. [Web] Going, C. C.; Williams, E. R. Supercharging with m-Nitrobenzyl Alcohol and Propylene Carbonate: Forming Highly Charged Ions with Extended, Near-Linear Conformations Anal. Chem. 2015, 87, 3973–3980. [Web] Cooper, R. J.; Heiles, S.; Williams, E. R. Effects of Electronic Structure on the Hydration of PbNO3+ and SrNO3+ Ion Pairs Phys. Chem. Chem. Phys. 2015, 17, 15963–15975. [Web] Heiles, S.; Cooper, R. J.; DiTucci, M. J.; Williams, E. R. Hydration of guanidinium depends on its local environment Chem. Sci. 2015, 6, 3420–3429. [Web] DiTucci, M. J.; Heiles, S.; Williams, E. R. Role of Water in Stabilizing Ferricyanide Trianion and Ion-Induced Effects to the Hydrogen-Bonding Water Network at Long Distance J. Am. Chem. Soc. 2015, 137, 1650–1657. [Web] [Featured in C&EN Magazine] O'Brien, J. T.; Williams, E. R. Ambient Infrared Laser Ablation Mass Spectrometry (AIRLAB-MS) of Live Plant Tissue with Plume Capture by Continuous Flow Solvent Probe Anal. Chem. 2015, 97, 2631–2638. [Web] Mortensen, D. N. and Williams, E. R. Investigating Protein Folding and Unfolding in Electrospray Nanodrops Upon Rapid Mixing Using Theta-Glass Emitters Anal. Chem. 2015, 87, 1281–1287. [Web] Cassou, C. A. and Williams, E. R. Desalting Protein Ions in Native Mass Spectrometry using Supercharging Reagents Analyst 2014, 139, 4810–4819. [Web] Mortensen, D. N. and Williams, E. R. Theta-Glass Capillaries in Electrospray Ionization: Rapid Mixing and Short Droplet Lifetimes Anal. Chem. 2014, 86, 9315–9321. [Web] Cooper, R. J.; Heiles, S.; DiTucci, M. J.; Williams, E. R. Hydration of Guanidinium: Second Shell Formation at Small Cluster Size J. Phys. Chem. A 2014 118, 5657–5666. [Web]