Hill, Ronald - University of Louisian at Monroe - Department of Basic Pharmaceutical Sciences

个人简介

1991 Ph.D., Pharmacy (Medicinal Chemistry) The Ohio State University Columbus, OH 1982 B.S., Chemistry University of Michigan Ann Arbor, MI

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Satyanarayanajois, S.D., Hill, R.A. (2011). Medicinal chemistry for 2020. Future Med. Chem. 14: 1765-1786 Johnson, Wilbur, Jr.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G., Jr.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; et al. Amended safety assessment of Sesamum indicum (sesame) seed oil, hydrogenated sesame seed oil, Sesamum indicum (sesame) oil unsaponifiables, and sodium sesameseedate. International Journal of Toxicology (2011), 30(Suppl. 1), 40S-53S. [and 4 other similar publications from the same group so far in 2011] Becker, Lillian C.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G., Jr.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; et al. Amended safety assessment of dodecylbenzenesulfonate, decylbenzenesulfonate, and tridecylbenzenesulfonate salts as used in cosmetics. International Journal of Toxicology (2010), 29(Suppl. 4), 288S-305S. [and 6 other similar publications from the same group in 2010] Khanfar MK, Hill RA, Kaddoumi A, El Sayed KA.* 2010. Combined ligand and structure-based virtual screening for identification of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability. J Med. Chem. 53(24), 8534-8545 Hill, Ronald A. Chapter 20: Hormone-Related Disorders–Nonsteroidal Therapies. In: Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry, 12th edit. John H. Block, John M. Beale, Jr., Eds., 2010. Zharikova, O. L.; Fokina, V. M.; Nanovskaya, T. N.; Hill, R. A.; Mattison, D. R.; Hankins, G. D. V.; Ahmed, M. S.* Identification of the major human hepatic and placental enzymes responsible for the metabolism of glyburide. Biochemical Pharmacology, 2009, 78(12), 1483-1490. Devarakonda, B.; Otto, D. P.; Judefeind, A.; Hill, R. A.; de Villiers, M. M.* Effect of pH on the solubility and release of furosemide from polyamidoamine (PAMAM) dendrimer complexes. International Journal of Pharmaceutics, 2007, 345, 142–153. Zharikova, O. L.; Ravindran, S.; Nanovskaya, T. N.; Hill, R. A.; Hankins, Gary D. V.; Ahmed, M. S.* Kinetics of glyburide metabolism by hepatic and placental microsomes of human and baboon. Biochemical Pharmacology 2007, 73, 2012–2019. Schulte, Marvin K.;* Hill, Ronald A.;* Bikádi, Zsolt;* Maksay, Gábor; Parihar, Harish S.; Joshi, Prasad; Suryanarayanan, Asha. The structural basis of ligand interactions in the 5-HT3 receptor binding site. In Biological and Biophysical Aspects of Ligand-Gated Ion Channel Receptor Superfamilies. Arias, Hugo R., editor. (Research Signpost Press, 2006, ISBN 81-7736-254-2), pp 127–154. Chilakapati, J., Korrapati, M.C., Hill, R.A., Warbritton, A., Latendresse, J.R., and Mehendale, H.M. Role of thioacetamide sulfoxide in saturation of toxicokinetics of thioacetamide. Toxicology 2007, 230, 105-116 Chilakapati, J., Korrapati, M.C., Shankar, K., Hill, R.A., Warbritton, A., Latendresse, J.R.and Mehendale, H.M. Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: effects of diet restriction and phenobarbital. Toxicol. Appl. Pharmacol. 2007, 219, 72-84 Selvan, R.; Zharikova, O. L.; Hill, R. A.; Nanovskaya, T. N.; Hankins, G. D. V.; Ahmed, M. S.* Identification of Glyburide Metabolites formed by Hepatic and Placental Microsomes of Humans and Baboons. Biochemical Pharmacology 2006, 72(12), 1730-1737. Devarakonda, B.; Hill, R. A.; Liebenberg, W.; Brits, M.; De Villiers, M. M.* Comparison of the aqueous solubilization of practically insoluble niclosamide by polyamidoamine (PAMAM) dendrimers and cyclodextrins. International Journal of Pharmaceutics, 2005, 304, 193–209 Chilikapati, J.; Shankar, K.; Korrapati, M. C.; Hill, R. A.; Mehendale, H. M.* Saturation Toxicokinetics of Thioacetamide: Role in Development of Liver Injury. Drug Metab. Dispos., 2005, 33, 1877–1885. Liu, D. L.; Hill, R. A.* Treatment of Certain ortho-Substituted Benzaldehydes with Nitronium Tetrafluoroborate in Acetonitrile Yields Nitrated a,a-Bisacetamido Toluenes. J. Org. Chem., in revision. Devarakonda, B.; Hill, R. A.; de Villiers, M. M.* The Effect of PAMAM Dendrimer Generation Size and Surface Functional Group on the Aqueous Solubility of Nifedipine. Int. J. Pharm., 2004, 284(1–2), 133–140 Hill, R. A.* Rudra, S.; Peng, B.; Roane, D. S.; Bounds, J. K.; Zhang, Y.; Adloo, A. A; Lu, T. Hydroxyl-Substituted Sulfonylureas as Potent Inhibitors of Specific [3H]Glyburide Binding to Rat Brain Synaptosomes. Bioorg. Med. Chem., 2003, 11, 2099-2113. Goskonda, V. R.; Hill, R. A.; Khan, M. A.; Reddy, I. K.* Permeability of Chemical Delivery Systems Across Rabbit Corneal (SIRC) Cell Line and Isolated Corneas: A Comparative Study. Pharm. Dev. Technol. 2000, 5, 409–416. Wu, J.; Barrois, M. J.; Zhou, L. H.; Ace, L. N., Jr.;* Liu, D. L.; Danthi, S. N.; Hill, L. J.; Hill, R. A.* Potential Prodrugs of a Triply-Ionized a-Amino Acid AMPA Antagonist: Biotransformation in Rat Brain Homogenates and Preliminary In Vivo Studies. In active preparation for J. Pharm. Sci.; partial abstract published: AAPS PharmSci. 1999, 4, S515.) Bhat, A.; Chang, H.-M.; Wallace, L. J.; Weinstein, D. M.; Shams, G.; Garris, C. C.; Hill, R. A.* 1,4-Dihydro-2,3-quinoxalinediones as Potential Flavin Metabolites and Excitatory Amino Acid Receptor Ligands. I. Synthesis and Pharmacological Evaluation of the Benzylic Oxidation Series of 1,4-Dihydro-6,7-dimethyl-2,3-quinoxalinedione. Bioorg. Med. Chem.1998, 6, 271–282. Danthi, S. N.; Hill, R. A.* Synthesis of chirally pure 2,5-disubstituted diketopiperazines derived from trisubstituted phenylalanines. J. Heterocycl. Chem. 1997, 34, 835–844. Hill, R. A.; Wallace, L. J.; Miller, D. D.*; Tai, H.; Layer, R. T.; Weinstein, D.; Willins, D. L.; Uretsky, N. J. Structure-activity Studies for a-Amino-3-hydroxy-5-methyl-4-isoxazolepropanoic Acid Receptors: Acidic Hydroxyphenylalanines. J. Med. Chem. 1997, 40, 3182–3191. Yamreudeewong, W.*; Danthi, S. N.; Hill, R. A.* Stability of Ondansetron for Injection Admixtures with Various Beverages for Oral Administration. Am. J. Health-Syst. Pharm. 1995, 52, 2011–2014. Hill, R. A.; Labanowski, J. K.*; Heisterberg, D. J.; Miller, D. D.* Formic Acid: Methylamine Complex Studied by the Hartree-Fock and Density Functional Approaches. In Density Functional Methods in Chemistry (Springer-Verlag: New York, 1991) pp. 357–372. Ronald A. Hill. Part 1. Design, Synthesis, and Structure-Activity Studies of Molecules with Activity at Non-NMDA Glutamate Receptors: Hydroxyphenylalanines, Quinoxalinediones and Related Molecules. Part 2. Computational Studies on the Interaction of the Dopamine Amino Group and Amino Group Replacements with Carboxylate Anions as a Model for Receptor Interactions. Ph.D. Dissertation, The Ohio State University, Columbus, Ohio, 1991.