贾铁争 - 南方科技大学

个人简介

贾铁争，2000-2003年本科毕业于中国海洋大学药学专业，获得医学学士学位。2003-2006年硕士毕业于中国海洋大学药物化学专业，获得医学硕士学位，导师：顾谦群教授，朱伟明教授，研究方向：海藻真菌活性次级代谢产物研究。2012-2015年博士毕业于宾夕法尼亚大学（University of Pennsylvania）化学系，获得有机化学博士学位，导师： Patrick Walsh教授，研究方向：钯催化亚砜C-C键和C-S键构建的新方法。2015-2017年在加州理工学院（California Institute of Technology, Caltech）从事博士后研究，研究方向为DNA化学生物学，导师： Peter B. Dervan院士。自2017年底加入南方科技大学化学系，任助理教授/实验室PI，博士生导师。以第一作者和通讯作者身份，在JACS, ANIE等国际顶尖化学期刊上，发表论文20余篇。

研究领域

1. DNA化学生物学，以基因碱基错配为靶点的抗癌药物研发，基于细胞和动物模型的活性测试 2. 新型吡咯-咪唑多肽类化学生物学探针的构建 3. 高价硫化合物合成的新方法学研究 4. 新颖非催化有机方法学研究

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Liang, Q.#; Wells, L. A.#; Han, K.; Chen, S.; Kozlowski, M. C.*; Jia, T. *Synthesis of Sulfilimines Enabled by Copper-Catalyzed S-Arylation of Sulfenamides.J. Am. Chem. Soc. 2023, 10.1021/jacs.2c12947. Liu, H.#; Li, G.#; Peng, Z.; Zhang, S.; Zhou, X.; Liu, Q.; Wang, J.; Liu, Y.*; Jia, T.*Tagging Peptides with a Redox Responsive Fluorescent Probe Enabled by Photoredox Difunctionalization of Phenylacetylenes with Sulfinates and Disulfides.JACS Au 2022, 2, 2821−2829. Li, X.; Shi, Z.; Jia, T.*Potentiometric Determination of Acid Dissociation Constants (pKa) for an Anticancer Pyrrole-Imidazole Polyamide.ACS Med. Chem. Lett. 2022, 13, 1739−1744. Xu, Z.; Su, S.; Li, X.; Jia, T.*A Facile and Mild Alkylation Protocol of NH-Diphenyl Sulfondiimines.Synlett 2023, 34, 429–432. Meng, T.#; Wells, L. A.#; Wang, T.; Wang, J.; Zhang, S.; Wang, J.; Kozlowski, M. C.*; Jia, T.* Biomolecule-Compatible Dehydrogenative Chan–Lam Coupling of Free Sulfilimines. J. Am. Chem. Soc. 2022, 10.1021/jacs.2c04627. Wang, Y.; Meng, T.; Su, S.; Han, L.; Zhu, N.*; Jia, T.* Copper‐Catalyzed Chan‐Lam Coupling of NH‐Diaryl Sulfondiimines. Adv. Synth. Catal. 2022, 364, 2040–2046. Oh, J.; Jia, T.; Xu, J.; Chong, J.; Dervan, P. B.*; Wang, D.* RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder. Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2114065119. Li, X.; Wang, C.; Jia, T.* Recent Advances in N-Arylation of NH-Sulfoximines and their Applications. Chin. J. Org. Chem. 2022, 42, 714-731. (Invited) Bai, J.#; Wang, T.#; Dai, B.#; Liu, Q.*; Yu, P.*; Jia, T.* Radical Anion Promoted Chemoselective Cleavage of Csp2–S Bond Enables Formal Cross-Coupling of Aryl Methyl Sulfones with Alcohols. Org. Lett. 2021, 23, 5761-5765. Wang, C.#; Zhang, H.#; Wells, L. A.#; Liu, T.; Meng, T.; Liu, Q.; Walsh, P. J.; Kozlowski, M. C.*; Jia, T.* Autocatalytic photoredox Chan-Lam coupling of free diaryl sulfoximines with arylboronic acids. Nat. Commun. 2021, 12, 932. Zhou, X.; Peng, Z.; Wang, G. P.; Liu, Q.*; Jia, T.* Atom Transfer Radical Addition to Styrenes with Thiosulfonates Enabled by Synergetic Copper/Photoredox Catalysis. Org. Lett. 2021, 23, 1054-1059. Peng, Z.; Yin, H.; Zhang, H.; Jia, T.* Regio- and Stereoselective Photoredox-Catalyzed Atom Transfer Radical Addition of Thiosulfonates to Aryl Alkynes. Org. Lett. 2020, 22, 5885–5889. Li, G.; Nieves-Quinones, Y.; Zhang, H.; Liang, Q.; Su, S.; Liu, Q.; Kozlowski, M. C.*; Jia, T.* Transition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of C-S bond. Nat. Commun. 2020, 11, 2890. Liang, Q.; Walsh, P. J.; Jia, T.* Copper-Catalyzed Intermolecular Difunctionalization of Styrenes with Thiosulfonates and Arylboronic Acids via a Radical Relay Pathway. ACS Catal. 2020, 10, 2633-2639. Chen, C. Y.; Li, Y.; Jia, T.; He, L.; Hare, A. A.; Silberstein, A.; Gallagher, J.; Martinez, T. F.; Stiles, J. W.; Olenyuk, B.; Dervan, P. B.; Stiles, B. L.* Repression of the transcriptional activity of ERRalpha with sequence-specific DNA-binding polyamides. Med. Chem. Res. 2020, 29, 607-616. Xu, W.; Wong, M.-C.; Guo, Q.; Jia, T.; Hao, J.* Healable and shape-memory dual functional polymers for reliable and multipurpose mechanical energy harvesting devices. Journal of Materials Chemistry A. 2019, 7, 16267-16276. Jiang, H.; Bellomo, A.; Zhang, M.; Carroll, P. J.; Manor, B. C.; Jia, T.*; Walsh, P. J.* Palladium-Catalyzed Direct C-H Arylaion of 3- (Methylsulfinyl)thiophenes. Org. Lett. 2018, 20, 2522–2525. Jia, T.; Zhang, M.; McCollom, S. P.; Bellomo, A.; Montel, S.; Mao, J.; Dreher, S. D.; Welch, C. J.; Regalado, E. L.; Williamson, R. T.; Manor, B. C.; Tomson, N. C.; Walsh, P. J. “Palladium-Catalyzed Enantioselective Arylation of Aryl Sulfenate Anions: A Combined Experimental and Computational Study”, J. Am. Chem. Soc. 2017, 139, 8337-8345. Jia, T.; Zhang, M.; Jiang, H.; Wang, C. Y.; Walsh, P. J. “Palladium Catalyzed Arylation of Alkyl Sulfenate Anions.”, J. Am. Chem. Soc. 2015, 137, 13887–13893. Jia, T.; Bellomo, A.; Montel, S.; Zhang, M.; El Baina, K.; Zheng, B.; Walsh, P. J. “Diaryl Sulfoxides from Aryl Benzyl Sulfoxides: A Single Palladium-Catalyzed Triple Relay Process”, Angew. Chem., Int. Ed. 2014, 53, 260-264.