刘建钊 - 浙江大学 - 高分子科学与工程学系

个人简介

2006年毕业于浙江大学高分子科学与工程学系获得学士学位； 2011年毕业于香港科技大学化学系获得博士学位； 2011-2012年香港科技大学化学系从事博士后工作； 2012-2015年芝加哥大学化学系从事博士后研究工作； 2015年6月回浙江大学高分子科学与工程学系任教。

研究领域

生物大分子核酸化学修饰及标记信使RNA m6A甲基化机理研究荧光生物探针及显影

近期论文

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A unimolecular theranostic system with H2O2-specific response and AIE-activity for doxorubicin releasing and real-time tracking in living cells Gao, X. Y. ; Cao, J. ; Song, Y. N. ; Shu, X. ; Liu, J. Z.*; Sun, J. Z. ; Liu, B.* ; Tang, B. Z*. RSC Advances. 2018, 8, 10975-10979. VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation Yue Y.#; Liu, J.#; Cui, X.#; Cao, J.#; Luo, G.; Zhang, Z.; Cheng, T.; Gao, M.; Shu, X.; Ma, H.; Wang, F.; Wang, X.; Shen, B.; Wang, Y.; Feng, X.; He, C.*& Liu, J. Z*.Cell Discovery, 2018, 4, 10. (#contributed equally) N6-Allyladenosine: a New Small Molecule for RNA Labeling Identified by Mutation Assay Shu, X.#; Dai, Q.#; Wu, T.#; Bothwell, I. R.; Yue, Y.; Zhang, Z.; Cao, J.; Fei, Q.; Luo, M.; He, C*.; Liu, J. Z*.J. Am. Chem. Soc. 2017,139 (48), 17213–17216 (#contributed equally) A Two-Channel Responsive Fluorescent Probe with AIE Characteristics and Its Application for Selective Imaging of Superoxide Anions in Living Cells Gao, X,Y.; Feng, G.; Manghnani, P. N.; Hu, F.; Jiang, N.; Liu, J. Z.; Liu, B*.; Sun, J. Z*.; Tang, B. Z*. Chem. Commun. 2017, 53, 1653-1656. Abundant DNA 6mA Methylation during Early Embryogenesis of Zebrafish and Pig. Liu, J. Z.#;; Zhu, Y.#;; Luo, G. Z.#;; Wang, X. X.#;; Yue, Y. N.; Wang, X. N.; Zong, X.; Chen, K.; Yin, H.; Fu, Y.; Han, D. L.; Wang, Y. Z*.; Chen, D. H*.; He, C*. Nat. Commun. 2016, 7, 13052. (#;contributed equally) Characterization of Eukaryotic DNA N6-Methyladenine by a Highly Sensitive estriction Enzyme-Assisted Sequencing Luo, G. Z.; Wang, F.; Weng, X. C.; Chen, K.; Hao, Z. Y.; Yu, M.; Deng, X.; Liu, J. Z.; He, C.; Nat. Commun. 2016, 7, 11301. N6-Methyladenine DNA Modification in Drosophila Zhang, G.; Huang, H.; Liu, D.; Cheng, Y.; Liu, X.; Zhang, W.; Yin, R.; Zhang, D.; Zhang, P.; Liu, J. Z.; Li, C.; Liu, B.; Luo, Y.; Zhu, Y.; Zhang, N.; He, S.; He, C.; Wang, H.; Chen, D. Cell. 2015, 161, 893-906. DNA Methylation on N6-Adenine in C. elegans Greer, Eric L.; Blanco, Mario A.; Gu, L.; Sendinc, E.; Liu, J. Z.; Aristizábal-Corrales, D.; Hsu, C.-H.; Aravind, L.; He, C.; Shi, Y. Cell 2015, 161, 868-878. N6-Methyldeoxyadenosine Marks Active Transcription Start Sites in Chlamydomonas Fu, Y.; Luo, G.-Z.; Chen, K.; Deng, X.; Yu, M.; Han, D.; Hao, Z.; Liu, J. Z.; Lu, X.; Doré, Louis C.; Weng, X.; Ji, Q.; Mets, L.; He, C. Cell 2015, 161, 879-892. RNA N6-Methyladenosine Methylation in Post-transcriptional Gene Expression Regulation Yue, Y.#;; Liu, J. Z.#;; He, C. Genes Dev. 2015, 29, 1343-1355. A METTL3-METTL14 Complex Mediates Mammalian Nuclear RNA N-6-Adenosine Methylation Liu, J. Z.#;;Yue, Y.#;; Han, D.; Wang, X.; Fu, Y.; Zhang, L.; Jia, G.; Yu, M.; Lu, Z.; Deng, X.; Dai, Q.; Chen, W.; He, C. Nat. Chem. Biol. 2014, 10, 93-95 (#;;contributed equally). A Protein Engineered to Bind Uranyl Selectively and with Femtomolar Affinity Zhou, L.; Bosscher, M.; Zhang, C.; Özçubukçu, S.; Zhang, L.; Zhang, W.; Li, C. J.; Liu, J. Z.; Jensen, M. P.; Lai, L.; He, C. Nat. Chem. 2014, 6, 236-241. Direct Visualization of Surface-Assisted Two-Dimensional Diyne Polycyclotrimerization Zhou, H.#;; Liu, J. Z.#;; Du, S.#;; Zhang, L.; Li, G.; Zhang, Y.; Tang, B. Z.; Gao, H. J. Am. Chem. Soc. 2014, 136, 5567-5570 (#;;contributed equally). Full-Range Intracellular pH Sensing by an Aggregation-Induced Emission-Active Two-Channel Ratiometric Fluorogen Chen, S.; Hong, Y.; Liu, Y.; Liu, J. Z.; Leung, C. W. T.; Li, M.; Kwok, R. T. K.; Zhao, E.; Lam, J. W. Y.; Yu, Y.; Tang, B. Z. J. Am. Chem. Soc. 2013, 135, 4926-4929. Real-Time Monitoring of Cell Apoptosis and Drug Screening Using Fluorescent Light-up Probe with Aggregation-Induced Emission Characteristics Shi, H.; Kowk, R. T. K.; Liu, J. Z.; Xing, B.; Tang, B. Z.; Liu, B. J. Am. Chem. Soc. 2012, 34, 17972-17981. Specific Detection of Integrin αvβ3 by Light-up Bioprobe with Aggregation-Induced Emission Characteristics Shi, H.; Liu, J. Z.; Geng, J.; Tang, B. Z.; Liu, B. J. Am. Chem. Soc. 2012, 134, 9569-9572. Monitoring and Inhibition of Insulin Fibrillation by a Small Organic Fluorogen with Aggregation-Induced Emission Characteristics Hong, Y.; Meng, L.; Chen, S.; Leung, C. W. T.; Da, L.; Mahtab, F.; Silva Manzano, D.; Liu, J. Z.; Lam, J. W. Y.; Huang, X.; Tang, B. Z. J. Am. Chem. Soc. 2012, 134,1680-1689. What Makes Efficient Circularly Polarized Luminescence in Condensed Phase: Aggregation-Induced Dichroism and Light Emission Liu, J. Z.; Su, H.; Meng, L.; Zhao, Y.; Deng, C.; Ng, J. C. Y.; Lu, P.; Faisal, M.; Lam, J. W. Y.; Huang, X.; Wu, H.; Wong, K. S.; Tang, B. Z. Chem. Sci. 2012, 3, 2737-2747. An AIE-Active Hemicyanine Fluorogen with Stimuli-Responsive Red/Blue Emission: Extending the pH Sensing Range by “Switch + Knob” Effect Chen, S.#;; Liu, J. Z.#;; Liu, Y.; Su, H.; Hong, Y.; Jim, C. K. W.; Kwok, R. T. K.; Zhao, N.; Qin, W.; Lam, J. W. Y.; Wong, K. S.; Tang, B. Z. Chem. Sci. 2012, 3, 1804-1809 (#;contributed equally). Deciphering Mechanism of Aggregation-Induced Emission (AIE): Is E–Z Isomerization Involved in an AIE Process? Tseng, N.#;; Liu, J. Z.#;; Ng, J. C. Y.; Lam, J. W. Y.; Sung, H. Y.; Williams, I. D.; Tang, B. Z. Chem. Sci. 2012, 3, 493-497 (#;contributed equally).