个人简介
Dr. Li obtained his B.Sc. degree in Chemistry from Zhejiang (Hangzhou) University, China, in 1983, and his Ph.D. degree in Chemistry from the University of Michigan, Ann Arbor, USA, in 1989, under the direction of Professor David M. Lubman. After graduation, he joined the Department of Chemistry at the University of Alberta, Edmonton, Alberta in July 1989. He was an Assistant Professor from 1989 to 1994 and an Associate Professor from 1994 to 1999. He has been a Full Professor since July 1999. He has also been an Adjunct Professor of Biochemistry Department, Faculty of Medicine, since January 2008. He has a Visiting Professorship at Zhejiang University supported by K. P. Chao’s Hi-Tech Foundation for Scholars and Scientists since 2006. Dr. Li was a visiting scientist at Hewlett Packard Research Lab (now Agilent), Palo Alto, CA (on sabbatical leave) from July 1998 to June 1999. He served as Director, Alberta Cancer Board Proteomics Resource Lab from February 2000 to December 2005. He serves as Chair, Analytical Chemistry Division of Chemistry Department since July 2007.
Dr. Li is a Canada Research Chair in Analytical Chemistry (Tier 1, 2005-2012; renewed for 2012-2019) and has won several awards including McBryde Medal (2001) from the Canadian Society for Chemistry, Faculty of Science Outstanding Research Award (2002), McCalla Professorship (2002-2003), and Killam Annual Professorship (2004-2005) from the University of Alberta. He received the Young Explorers Prize from the Canadian Institute for Advanced Research (CIAR), which was given to Canada’s top twenty researchers aged forty or under in science and engineering (2002) as chosen by a panel of international judges. He was the recipient of the Rutherford Memorial Medal in Chemistry from the Royal Society of Canada (2003). He received The F.P. Lossing Award from the Canadian Society for Mass Spectrometry in 2006, The Maxxam Award from the Canadian Society for Chemistry in 2009 and Gerhard Herzberg Award from the Canadian Society for Analytical Sciences and Spectroscopy in 2010. He is a fellow of the Chemical Institute of Canada since 2001.
Dr. Li has published more than 200 research papers mainly in the area of analytical mass spectrometry. He has given many invited talks including Hong Kong Polytechic University Distinguished Lecture in 2011, Distinguished Lectureship on Cerebrating the 50th Anniversary of Hong Kong Baptist University Faculty of Science in 2011, and Thermo Fisher Scientific Distinguished Scientist Lecture at the University of Montreal in 2013.
Dr. Li is currently an editor of Analytica Chimica Acta, an international journal on analytical chemistry with an Impact Factor of 4.712 in 2015 (2005-present). He is a member of the editorial advisory boards for Current Analytical Chemistry (2004-present), Analytical Chemistry Insights (2006-present), Journal of Advanced Research (Elsevier) (2014-), Biophysics Reports (Springer) (2015-) and Chemical Data Collections (Elsevier) (2015-). Dr. Li was a member of the editorial advisory boards for Journal of the American Society for Mass Spectrometry (2001-2006), Canadian Journal of Chemistry (2004-2006) and Clinical Proteomics (2011-2016). He was a member of Analytical Chemistry’s A-Page Advisory Panel (2006-2008).
研究领域
Dr. Li's research is in the area of analytical mass spectrometry (MS). The major objectives of the research are to develop advanced methods and strategies, primarily based on MS, for the detection and characterization of biological molecules including proteins (proteomics) and metabolites (metabolomics), and to apply these methods to study real-world biological systems. The latter is being accomplished through active collaboration with researchers at the forefront of their disciplines.
For students who are interested in Analytical Chemistry, Dr. Li's lab provides a good learning environment for state-of-the-art analytical techniques and methods, including biological and pharmaceutical sample handling methods, chemical separation techniques (e.g., multi-dimensional liquid chromatography), mass spectrometry (e.g., TOF MS, Ion trap MS, FT-MS, and tandem MS), and data processing/bioinformatics tools.
For students with strong biology background (e.g., an undergraduate degree in biological sciences or biochemistry) who are interested in Chemical Biology, Dr. Li's group offers the unique opportunity for training in both chemistry and biology, with the assistance of collaborators in biosciences such as faculty members in Biological Sciences, Biochemistry, Cell Biology, Oncology, and Computational Biology. Joint supervision of a chemical biology research project can also be arranged. We are particularly interested in applying analytical techniques and methods in solving biological problems. These include metabolomics and proteomics applications in systems biology and disease biomarker discovery research.
近期论文
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Deying Chen, Xiaoling Su, Nan Wang, Yunong Li, Hua Yin, Liang Li* and Lanjuan Li*, 2016, “Chemical Isotope Labeling LC-MS for Monitoring Disease Progression and Treatment in Animal Models: Plasma Metabolomics Study of Osteoarthritis Rat Model”, Scientific Reports, in press.
Yiman Wu, Femke Streijger, Yining Wang, Guohui Lin, Sean Christie, Jean-Marc Mac-Thiong, Stefan Parent, Christopher S. Bailey, Scott Paquette, Michael C. Boyd, Tamir Ailon, John Street, Charles G. Fisher, Marcel F. Dvorak, Brian K. Kwon* and Liang Li*, 2016, “Parallel Metabolomic Profiling of Cerebrospinal Fluid and Serum for Identifying Biomarkers of Injury Severity after Acute Human Spinal Cord Injury”, Scientific Reports, 6, 38718; doi: 10.1038/srep38718. (Open Access Article)
Lina Yao, Hui Shen, Nan Wang, Jaspaul Tatlay, Liang Li, Tin Wee Tan and Yuan Kun Lee, 2016, “Elevated acetyl-CoA by amino acid recycling fuels microalgal neutral lipid accumulation in exponential growth phase for biofuel production”, Plant Biotechnology, in press.
Shuang Zhao, Xian Luo and Liang Li, 2016, “Chemical Isotope Labeling LC-MS for High Coverage and Quantitative Profiling of the Hydroxyl Submetabolome in Metabolomics”, Anal. Chem. 88, 10617-10623. (Open Access Article)
Tao Huan†, Jia Wen Xian†, Wing Nang Leung, Liang Li* and Chun Wai Chan*, 2016, “Cerebrospinal Fluid Metabolomics After Natural Product Treatment in an Experimental Model of Cerebral Ischemia”, OMICS A Journal of Integrative Biology, 20, 670-680.
Xiuju Li, Aruna Augustine, Difei Sun, Liang Li and Larry Fliegel, 2016, “Activation of the Na+/H+ exchanger in isolated cardiomyocytes through β-Raf dependent pathways. Role of Thr653 of the cytosolic tail”, Journal of Molecular and Cellular Cardiology, 99, 65-75.
Tao Huan, Dean A. Troyer and Liang Li, 2016, “Metabolite Analysis and Histology on the Exact Same Tissue: Comprehensive Metabolomic Profiling and Metabolic Classification of Prostate Cancer”, Scientific Reports, 6, 32272; doi:10.1038/srep32272. (Open Access Article)
Kevin Hooton, Wei Han and Liang Li, 2016, “Comprehensive and Quantitative Profiling of the Human Sweat Submetabolome Using High-Performance Chemical Isotope Labeling LC-MS”, Anal. Chem. 88, 7378-7386.
Weifeng Shen, Wei Han, Yunong Li, Zhiqi Meng, Leiming Cai and Liang Li, 2016, “Development of Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry for Silkworm Hemolymph Metabolomics”, Anal. Chim. Acta. 942, 1-11. (Cover Article)
Xian Luo, Shuang Zhao, Tao Huan, Difei Sun, R. Magnus N. Friis, Michael C. Schultz and Liang Li, 2016, “High-Performance Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry for Profiling the Metabolomic Reprogramming Elicited by Ammonium Limitation in Yeast”, J Proteome Res, 15, 1602-1612.
Francois V. Bolduc, Amanda Lau, Cory S. Rosenfelt, Steven Langer, Nan Wang, Lisa Smithson, Diana Lefebvre, R. Todd Alexander, Clayton T. Dickson, Liang Li, Allan B. Becker, Padmaja Subbarao, Stuart E. Turvey, Jacqueline Pei, Malcolm R. Sears, Piush J. Mandhane for the CHILD Study Investigators, 2016, “Cognitive enhancement in infants associated with increased maternal fruit intake during pregnancy: results from a birth cohort study with validation in an animal model”, EBioMedicine, 8, 331-340.
David Achaintre, Audrey Buleté, Cécile Cren-Olivé, Liang Li, Sabina Rinaldi, Augustin Scalbert, 2016, “Differential Isotope Labelling of 38 Dietary Polyphenols and their Quantification in Urine by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry”, Anal. Chem. 88, 2637-2644.
Liang Li, Nan Wang, Deying Chen, Xiaoling Su and Jing Jiang, 2016, “Proteomics Research in Infectious Disease”, in Infectious Disease, Lanjuan Li, Ed.; China People’s Health Publishing House, Beijing; Chapter 21, 34 pages.
Yiman Wu and Liang Li, 2016, “Sample Normalization Methods in Quantitative Metabolomics”, J Chromatogr. A, 1430, 80-95. (Editors’ Choice Review)
Xiaoling Su, Nan Wang, Deying Chen, Yunong Li, Yingfeng Lu, Tao Huan, Wei Xu, Liang Li* and Lanjuan Li*, 2016, “Dansylation Isotope Labeling Liquid Chromatography Mass Spectrometry for Parallel Profiling of Human Urinary and Fecal Submetabolomes”, Anal. Chim. Acta. 903, 100-109.
Hind Alqahtani, Nidhi Gupta, Karen Jung, Keshav Gopal, Abdulraheem Alshareef, Xiaoxia Ye, Fang Wu, Liang Li and Raymond Lai, 2016, “DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer”, Cellular Signalling, 28, 42-50.
Zhendong Li, Jaspaul Tatlay and Liang Li, 2015, “Nanoflow LC-MS for High-Performance Chemical Isotope Labeling Quantitative Metabolomics”, Anal. Chem. 87, 11468-11474.
Tao Huan, Chenqu Tang, Ronghong Li, Yi Shi, Guohui Li and Liang Li, 2015, “MyCompoundID MS/MS Search: Metabolite Identification Using a Library of Predicted Fragment-Ion-Spectra of 383,830 Possible Human Metabolites”, Anal. Chem. 87, 10619-10626. (Open Access Article)
Tao Huan, Yiman Wu, Chenqu Tang, Guohui Lin and Liang Li, 2015, “DnsID in MyCompoundID for Rapid Identification of Dansylated Amine- and Phenol-Containing Metabolites in LC-MS-Based Metabolomics”, Anal. Chem. 87, 9838–9845.
Wei Han and Liang Li, 2015, “Matrix Effect on Chemical Isotope Labeling and Its Implication in Metabolomic Sample Preparation for Quantitative Metabolomics”, Metabolomics, 11, 1733-1742.
Tao Huan and Liang Li, 2015, “Quantitative Metabolome Analysis Based on Chromatographic Peak Reconstruction in Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry”, Anal. Chem. 87, 7011-7016.
Ruokun Zhou, Tao Huan and Liang Li, 2015, “Development of Versatile Isotopic Labeling Reagents for Profiling the Amine Submetabolome by Liquid Chromatography Mass Spectrometry”, Anal. Chim. Acta. 881, 107-116.
Kathleen Bone, Peng Wang, Fang Wu, Chengsheng Wu, Liang Li, Julinor Bacani, and Susan Andrew and Raymond Lai, 2015, “NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair”, Blood Cancer Journal, 5, e311 (10 pages).
Kaiyuan Yang, Zohre Hashemi, Wei Han, Alena Jin, Han Yang, Jocelyn Ozga, Liang Li and Catherine Chan, 2015, “Hydrolysis Enhances Bioavailability of Proanthocyanidin-Derived Metabolites and Improves b-Cell Function in Glucose Intolerant Rats”, Journal of Nutritional Biochemistry, 26, 850-859.
Xiang Wang, Evan Berry, Samuel Hernandez-Anzaldo, Difei Sun, Ayinuer Adijiang, Liang Li, Dawei Zhang and Carlos Fernandez-Patron, 2015, “MMP-2 inhibits PCSK9-induced degradation of the LDL receptor in Hepa1-c1c7 cells”, FEBS Letters, 589, 490-496.
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