个人简介
Dr. Le is Distinguished University Professor and Canada Research Chair in Bioanalytical Technology and Environmental Health. He contributes to Department of Laboratory Medicine and Pathology (Faculty of Mediciena and Dentistry), Department of Public Health Sciences (School of Public Health), and Department of Chemistry (Faculty of Science), University of Alberta. He is Director of the Analytical and Environmental Toxicology Division. He is also a Guest Professor of Chinese Academy of Sciences (Dalian Institute of Chemical Physics, Research Center for Eco-Environmental Sciences, and Wuhan Institute of Virology), Peking University, Wuhan University, Zhejiang University, Guilin University of Technology, and Southwest University. Dr. Le is an Associate Editor for Environmental Health Perspectives.
Dr. Le obtained undergraduate training from Wuhan University (1979-1983). He obtained a M.Sc. degree from Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences (1983-1986) before he came to Canada and pursued a second M.Sc. degree at Brock University (1987-1988). He received his Ph.D. in Environmental/Analytical Chemistry from the University of British Columbia (1990-1993). He was subsequently awarded a prestigious Killam Postdoctoral Fellowship and carried out postdoctoral research in the Chemistry Department at the University of Alberta (1994). He was recruited to the Faculty of Medicine in 1995 and was promoted through the ranks to Professor in 2003.
In 2011, Dr. Le received two major awards simultaneously, Maxxam Award for "distinguished contribution to the field of analytical chemistry" and Environment Research and Development Award from the Chemical Institute of Canada "for distinguished contributions to research and/or development in the fields of environmental chemistry or environmental chemical engineering". Dr. Le previously received an Excellence in Mentoring Award (2009) and a Martha Cook Piper Research Prize (2000) from University of Alberta, an E.W.R. Steacie Fellowship (2000-2001) from Natural Sciences and Engineering Research Council of Canada (NSERC), a McBryde Medal (2002) from the Canadian Society for Chemistry, and Canada Research Chair in Bioanalytical Technology and Environmental Health (2000-2017) from the Government of Canada. Dr. Le is an elected Fellow of the Chemical Institute of Canada (2001) and Fellow of the Royal Society of Canada, Academy of Science (2010).
Dr. Le's group actively pursues research involving bioanalytical chemistry and environmental health sciences. Current projects include (i) analytical techniques and assays for molecules of environmental and biological significance; (ii) arsenic speciation, exposure, metabolism, and health effects; (iii) DNA damage and protein biomarkers; (iv) environmental health; and (v) water and food safety. The ultrasensitive techiques and assays enable studies of the environment and human health. This group enjoys extensive collaborations with multidisciplinary research groups both on campus and internationally.
Research in this group has been supported by Alberta Heritage Foundation for Medical Research, Alberta Health and Wellness, Alberta Innovates (Alberta Water Research Institute), Alberta Cancer Foundation, American Water Works Association Research Foundation (USA), Canada Foundation for Innovation, Canada Research Chairs Program, Canadian Institutes of Health Research, Canadian Water Network NCE, Environmental Protection Agency (USA), Health Canada, Metals in the Human Environment Research Network, National Cancer Institute (USA), National Cancer Institute of Canada (Terry Fox Foundation), National Institutes of Health (USA), and Natural Sciences and Engineering Research Council of Canada.
研究领域
Chemical Speciation of Trace Elements in Environmental and Biological Systems
Chemical speciation studies are essential to an understanding of toxicity and bioavailability of the element in the environment. Although total element concentration has been traditionally used to assess environmental impact and health risk of the element, it is now established that no meaningful interpretation can be made without speciation information. Each chemical form of an element has a different toxicity. For example, the toxicity of arsenic to animals varies from the more toxic arsenite, to the moderately toxic methylated arsenicals, to the essentially non-toxic arsenobetaine. We are interested in chemical speciation studies of metalloids (such as arsenic, antimony, and selenium) and heavy metals (such as mercury, lead, and cadmium) in the environment and biological systems, in view of their important impact on the environment and potential health risk.
近期论文
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Li, F.; Zhang, H.; Wang, Z.; Newbigging, A.M.; Reid, M.S.; Li, X.-F.; Le, X.C. Aptamers facilitating amplified detection of biomolecules. Analytical Chemistry, DOI: 10.1021/ac5037236.
Paliwoda, R.E.; Li, F.; Reid, M.S.; Lin, Y.; Le, X.C. Sequential strand displacement beacon for detection of DNA coverage on functionalized gold nanoparticles. Analytical Chemistry, 86, 6138-6143 (2014).
Chen, B.; Liu, Q.; Popowich, A.; Shen, S.; Yan, X.; Zhang, Q.; Li, X.-F.; Weinfeld, M.; Cullen, W.R.; Le, X.C. Therapeutic and analytical applications of arsenic binding to proteins. Metallomics, DOI: 10.1039/c4mt00222a.
Peng, H.; Hu, B.; Liu, Q.; Yang, Z.; Lu, X.; Huang, R.; Li, X.-F.; Zuidhof, M.J.; Le, X.C. Liquid chromatography combined with atomic and molecular mass spectrometry for speciation of arsenic in chicken liver. Journal of Chromatography A, 1370, 40-49 (2014).
Wu, M.; Qian, Y.; Boyd, J.M.; Le, X.C; Hrudey, S.E.; Li, X.-F. Direct large volume injection ultra-high performance liquid chromatography-tandem mass spectrometry determination of artificial sweeteners sucralose and acesulfame in well water. Journal of Chromatography A, 1359, 156-161 (2014).
Jensen-Fontaine, M.; Norwood, W.; Dixon, G.; Brown, M.; Le, X. C. Uptake and speciation of vanadium in the benthic invertebrate Hyalella Azteca. Environmental Science and Technology, 48, 731-738 (2014).
Zhang, Q.; Vakili, M.R.; Li, X.-F.; Lavasanifar, A.; Le, X.C. Polymeric micelles for GSH-triggered delivery of arsenic species to cancer cells. Biomaterials, 35, 7088-7100 (2014).
Dodmane, P. R.; Arnold, L.L.; Muirhead, D.E.; Suzuki, S, Yokohira, M.; Pennington, K.L.; Dav�, B.J.; Lu, X.; Le, X.C.; Cohen, S.M. Characterization of intracellular inclusions in the urothelium of mice exposed to inorganic arsenic. Toxicological Sciences, 137, 36-46 (2014).
Li, J.; Wang, W.; Zhang, H.; Le, X.C.; Li, X.-F. Glutathione mediated detoxification of halobenzoquinone drinking water disinfection byproducts in T24 cells. Toxicological Sciences, 141, 335-343 (2014).
Banerjee, M.; Carew, M.W.; Roggenbeck, B.A.; Naranmandura, H.; Le, X.C.; Leslie, E.M. A novel pathway for arsenic elimination: human multidrug resistance protein 4 (MRP4/ABCC4) mediates cellular export of dimethylarsinic acid [DMA(V)] and the diglutathione conjugate of monomethylarsonous acid [MMA(III)]. Molecular Pharmacology, 86, 168-179 (2014).
Anwar-Mohamed, A.; Elshenawy, O.H.; Soshilov, A.A.; Denison, M.S.; Le, X.C.; Lars-Oliver Klotz, L.O.; El-Kadi, A.O.S. Methylated pentavalent arsenic metabolites are bifunctional inducers as they induce Cytochrome P450 1A1 (CYP1A1) and NAD(P)H: quinone oxidoreducatase (NQO1) through AhR and Nrf2 dependent mechanisms. Free Radical Biology and Medicine, 67, 171-187 (2014).
Normandin, L.; Ayotte, P.; Levallois, P.; Ibanez, Y.; Courteau, M.; Kennedy, G.; Chen, L.; Le, X.C.; Bouchard, M. Biomarkers of arsenic exposure and effects in a Canadian rural population exposed through groundwater consumption. Journal of Exposure Science and Environmental Epidemiology, 24, 127-134 (2014).
Pourrezaei, P.; Alpatova, A.; Chelme-Ayala, P.; Perez-Estrada, L.A.; Jensen-Fontaine, M.; Le, X.C.; Gamal El-Din, M. Impact of petroleum coke characteristics on the adsorption of the organic fractions from oil sands process-affected water. International Journal of Environmental Science and Technology, 11, 2037-2050 (2014).
Deng, B.; Lin, Y.; Wang, C.; Li, F.; Wang, Z.; Zhang, H.; Li, X.-F.; Le, X.C. Aptamer binding assays for proteins: The thrombin example-A review. Analytica Chimica Acta, 837, 1-15 (2014).
Li, F.; Aeran, R.; Pone, E. J.; Kang D.-K.; Liu L.; Le X.C.; Zhao W. Probe and control of cell-cell interactions using bioengineered tools. In Karp, J.M.; Zhao, W. (Eds.. Miro- and Nanoengineering of the Cell Surface. Elsevier. Chapter 15, 349-370 (2014). ISBN: 978-1-4557-3146-6.
Ali, M.M.; Li, F.; Zhang, Z.Q.; Zhang, K.X.; Kang, D.-K.; Le, X.C.; Zhao, W. Rolling circle amplification: A versatile tool for chemical biology, materials science and medicine. Chemical Society Reviews, 43, 3324-3341 (2014).
Zhang, H.; Li, F.; Dever, B.; Li, X.-F.; Le, X.C. DNA-mediated homogeneous binding assays for nucleic acids and proteins. Chemical Reviews, 113(4), 2812-2841 (2013).
Zhang, H.; Li, F.; Dever, B.; Wang, C.; Li, X.-F.; Le, X.C. Assembling DNA through affinity binding to achieve ultrasensitive protein detection. Angewante Chemie International Edition, 52, 10698-10705 (2013).
Li, F.; Zhang, H.; Wang, Z.; Li, X.; Li, X.-F.; Le, X. C. Dynamic DNA assemblies mediated by binding-induced DNA strand displacement. Journal of the American Chemical Society, 135, 2443-2446 (2013).
Li, F.; Lin, Y.; Le, X.C. Binding-induced formation of DNA three-way junction and its application to protein detection and DNA strand displacement. Analytical Chemistry, 85(22), 10835-10841 (2013).
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