近期论文
查看导师最新文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
Yuanxiang Wang*, Wenhao Hu, Yanqiu Yuan*. Protein Arginine Methyltransferase 5 (PRMT5) as an Anti-Cancer Target and Its Inhibitor Discovery. J. Med. Chem. 2018, 61, 9429-9441. Yuanxiang Wang, Yanmei Hu, Shuting Xu, Yongtao Zhang, Rami Musharrafieh, Raymond Kin Hau, Chunlong Ma, and Jun Wang*. In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses. J. Med. Chem. 2018, 61, 1074-1085 Yuanxiang Wang, Danny Hung-Chieh Chou*. A Thiol–Ene Coupling Approach to Native Peptide Stapling and Macrocyclization. Angew. Chem. Int. Ed. 2015, 54, 10931-10934. Yuanxiang Wang#, Christine E. Kaiser#, Brendan Frett, Hong-yu Li*. Targeting Mutant KRAS for Anticancer Therapeutics: A Review of Novel Small Molecule Modulators. J. Med. Chem., 2013, 56, 5219-5230. Yuanxiang Wang#, Jing Ai#, Ying Wang, Yi Chen, Lu Wang, Gang Liu, Meiyu Geng*, Ao Zhang*. Synthesis and c-Met kinase inhibition of 3,5-di- and 3,5,7-tri-substituted quinolines: Identifica- tion of 3-(4-acetylpiperazin-1-yl)-5-(3-nitroben-zylamino)-7-(trifluoromethyl) quinoline as a novel anticancer agent. J. Med. Chem. 2011, 54, 2127–2142. Yuanxiang Wang, Benjamin J. Bruno, Sean Cornillie, Jason M. Nogieira, Diao Chen, Thomas E. Cheatham III, Carol S. Lim, and Danny Hung-Chieh Chou*. Application of Thiol-yne/Thiol-ene Reactions for Peptide and Protein Macrocyclizations. Chem. Eur. J. 2017, 29, 7087-7092. Yuanxiang Wang, Brendan Frett, Hong-yu Li*. Efficient Access to 2,3-Diarylimidazo[1,2‑a]pyridines via a One-Pot, Ligand-Free, Palladium-Catalyzed Three-Component Reaction underMicrowave Irradiation. Org. Lett. 2014, 16, 3016-3019. Yuanxiang Wang, Brendan Frett, Nick McConnell, Hong-yu Li*. Metal-Free, Efficient Hydrazination of Imidazo[1,2-a]pyridine with Diethyl Azodicarboxylate in Neutral Media. Org. Biomol. Chem. 2015, 13, 2985-2964. Yuanxiang Wang, Biswajit Saha, Fang Li, Brendan Frett, Hong-yu Li*. An Expeditious Approach to Access 2-Arylimidazo[1,2-a]pyridin-3-ol From 2-amino pyridine Through a Novel Petasis Based Cascade Reaction. Tetrahedron Lett. 2014, 55, 1281-1284. Yuanxiang Wang, Jing Ai, Jinfeng Yue, Xiao Peng, Yichun Ji, Ailing Zhao, Xin Gao, Ying Wang, Yi Chen, Gang Liu, Zhaobing Gao, Meiyu Geng*, Ao Zhang*. Further SAR studies on 3,5-diamino-7-trifluoromethylquinolines as highly potent tyrosine kinase c-Met inhibitors: efforts to correct hERG inhibition. Med. Chem. Commun. 2012, 3, 1423-1427. Yuanxiang Wang, Jing Ai, Gang Liu, Meiyu Geng, Ao Zhang. Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: Key precursors to potent c-Met inhibitors. Org. Biomol. Chem. 2011, 9, 5930-5933. Yuanxiang Wang, Ao Zhang. Expeditious synthesis of 2,3-dihydro-2-alkoxy-3- methylene- benzofurans from N-benzofuran-3-ylmethyl N,N,N-trialkylammonium bromides. Tetrahedron 2009, 65, 6986-6990. Diao Chen, Maria Disotuar, Xiaochun Xiong, Yuanxiang Wang, Danny Hung-Chieh Chou*. Selective N-terminal Functionalization of Native Peptides and Proteins. Chem. Sci.in press. Fang Li, Yanmei Hu, Yuanxiang Wang, Chunlong Ma, Jun Wang. Expeditious Lead Optimization of Isoxazole-Containing Influenza A Virus M2-S31N Inhibitors Using the Suzuki–Miyaura Cross-Coupling Reaction. J. Med. Chem., 2017, 60, 1580-1590. Fang Li, Chunlong Ma, Yanmei Hu, Yuanxinag Wang, Jun Wang, Discovery of potent antivirals aganist amantadine-resistant influenza A viruses by targeting the M2-S31N proton channel. ACS Infect Dis, 2016, 2, 726-733. Brendan Frett, Nick McConnell, Catherine C. Smith, Yuanxiang Wang, Neil P. Shah, Hong-yu Li. Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors. Eur. J. Med. Chem. 2015, 94, 123-131. Brendan Frett, Nick McConnell, Yuanxiang Wang, Zhigang Xu, Andrew Ambrose, Hong-yu Li. Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studies. Med. Chem. Commun. 2014, 5, 1507-1514. Brendan Frett, Yuanxiang Wang, Hong-yu Li. Targeting the K-Ras/PDEδ Protein-Protein Interaction: The Solution for Ras-Driven Cancers or Just Another Therapeutic Mirage? ChemMedChem, 2013, 8, 1620-1622. Biswajit Saha, Brendan Frett, Yuanxiang Wang, Hong-yu Li. A p-toluenesulfinic acid-catalyzed three-component Ugi-type reaction and its application for the synthesis of a-amino amides and amidines. Tetrahedron Lett. 2013, 54, 2340–2343. Kui Wu, Jing Ai, Qiufeng Liu, TianTian Chen, Ailing Zhao, Xia Peng, Yuanxiang Wang, Yinchun Ji, Qizheng Yao, Yechun Xu, Meiyu Geng, Ao Zhang. Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors. Bioorg. Med. Chem. Lett. 2012, 22, 6368-6372.
京公网安备 11010802027423号