郭磊 - 中山大学

个人简介

教育经历 2001.09 – 2005.07 中国药科大学，制药工程，学士 2005.09 – 2008.07 中国药科大学，药物化学，硕士（导师黄文龙） 2006.10 – 2008.06 中科院上海有机化学研究所，生命有机国家重点实验室，联合培养（导师马大为） 2009.09 – 2013.02 香港浸会大学，有机化学，博士（导师黄文成）工作经历 2008.07 – 2009.08 中科院上海有机化学研究所，研究助理 2013.03 – 2016.12 香港浸会大学，博士后 2017.01 – 至今中山大学药学院，副教授，药物化学

研究领域

肿瘤细胞靶向、核仁RNA结构选择性染色的红色吲哚半花菁类探针分子：设计、合成和作用机制研究

近期论文

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(1) Lei Guo, Siu Wai Tsang, Tong-Xin Zhang, Kang-Lun Liu, Yi-Fu Guan, Bo Wang, Han-Dong Sun, Hong-Jie Zhang, Man Shing Wong, Efficient Semisynthesis of (−)-Pseudoirroratin A from (−)-Flexicaulin A and Assessment of Their Antitumor Activities, ACS Med. Chem. Lett. 2017, 8(3), 372−376. (2) Lei Guo, King Fai Li, Xiaoqin Zhang, Kok Wai Cheah, Man Shing Wong, Highly Efficient Multiphoton-Pumped Frequency-Upconversion Stimulated Blue Emission with Ultralow Threshold from Highly Extended Ladder-Type Oligo(p-phenylene)s, Angew. Chem. Int. Ed., 2016, 55(36): 10639-10644. (3) Lei Guo, Miu Shan Chan, Di Xu, Dick Yan Tam, Frédéric Bolze, Pik Kwan Lo, Man Shing Wong, Indole-based Cyanine as a Nuclear RNA-Selective Two-Photon Fluorescent Probe for Live Cell Imaging, ACS Chem. Biol., 2015, 10(5):1171-1175. (4) Lei. Guo, Man Shing Wong, Multiphoton Excited Fluorescent Materials for Frequency Upconversion Emission and Fluorescent Probes, Adv. Mater., 2014, 26(31): 5400-5428. (5) Lei Guo, King Fai Li, Man Shing Wong, Kok Wai Cheah, Star-shaped ladder-type ter(p-phenylene)s for efficient multiphoton absorption, Chem. Commun., 2013, 49(34): 3597-3599. (6) Hai Hua Fan#, Lei Guo#, King Fai Li, Man Shing Wong, Kok Wai Cheah, Exceptionally Strong Multiphoton-Excited Blue Photoluminescence and Lasing from Ladder-Type Oligo(p-phenylene)s, J. Am. Chem. Soc., 2012, 134(17): 7297-7300. (共同一作) (7) Lei Guo, Ben Li, Wenlong Huang, Gang Pei, Dawei Ma, Elaboration of the Oxazepine Ring System via CuI/L-Proline-Catalyzed Intramolecular Aryl Amination, Synlett, 2008, 12: 1833-1836.