个人简介

BSc, PhD Imperial College DSc London University

研究领域

My field of research is Synthetic Organic Chemistry - especially as applied to pharmaceutically relevant compounds, and several types of project within this area are being studied in my group: The synthesis of structurally complex natural products that have important biochemical and medicinal properties. The development of new strategy and methodology for making complicated structures

My field of research is Synthetic Organic Chemistry - especially as applied to pharmaceutically relevant compounds, and several types of project within this area being studied in my group: The synthesis of structurally complex natural products that have important biochemical and medicinal properties. The development of new strategy and methodology for making complicated structures. A brief formula outline of a few topics within these areas is shown below. The synthetic targets that are being examined are relevant to the treatment of heart disease (e.g., CP-225,917), or they show antitumor activity (CP-225,917, MPC1001, the otteliones), or have potential as drugs to control inflammatory diseases and metastasis (halichlorine). The methodology program involves exploration of the flourishing area of radical cyclization, which has become an extremely useful technique in synthetic organic chemistry, and the formation of cyclic compounds by intramolecular conjugate displacements.

近期论文

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Generation of Carbocycles by Intramolecular Conjugate Displacement: Scope and Mechanistic Insights. Wang, L.; Prabhudas, B.; Clive, D.L.J. J. Am. Chem. Soc. 2009, 131, 6003-6012. The Coumarin to Indole Transformation — a Method for Preparing 4-Halo-5-hydroxyindoles from Coumarins. Stoffman, E.J.; Clive, D.L.J. Org. Biomol. Chem. 2009, 7, 4862-4870. Total Synthesis of the Marine Alkaloid Halichlorine — Development and Use of a General Route to Chiral Piperidines. Liu, D.; Acharya, H.P.; Yu, M.; Wang, J.; Yeh, V.S.C.; Kang, S.; Chiruta, C.; Jachak, S.M.; Clive, D.L.J. J. Org. Chem. 2009, 74, 7417-7428. Desymmetrization of 4-Hydroxy-2,5-cyclohexadienones by Radical Cyclization: Synthesis of Optically Pure γ-Lactones. Sunasee, R.; Clive, D.L.J. Chem. Commun. 2010, 46, 701-703. Synthesis of 4-Haloserotonin Derivatives and Synthesis of the Toad Alkaloid Dehydrobufotenine. Stoffmann, E.J.; Clive, D.L.J. Tetrahedron 2010, 66, 4452-4461. 2,6-Disubstituted and 2,2,6-Trisubstituted Piperidines from Serine: Asymmetric Synthesis and further Elaboration. Acharya, H.P.; Clive, D.L.J. J. Org. Chem. 2010, 75, 5223-5233. Formation of unusual 7-membered heterocycles incorporating N and S by intramolecular conjugate displacement. Chen, Z.; Clive, D.L.J. J. Org. Chem. 2010, 75, 7014-7017. Conversion of 1,4-Diketones into p-Disubstituted Benzenes. Ziffle, V. E.; Cheng, P.; Clive, D.L.J. J. Org. Chem. 2010, 75, 8024-8038. The [[(tert-Butyl)dimethylsilyl]oxy]methyl Group for Sulfur Protection. Wang, L.; Clive, D.L.J. Org. Lett. 2011, 13, 1734-1737. Synthetic studies related to MPC1001: formation of a model epidithiodiketopiperazine. Wang, L.; Clive, D.L.J. Tetrahedron Lett. 2012, 53, 1504-1506. Formation of optically pure cyclic amines by intramolecular conjugate displacement. Cheng, P.; Clive, D.L.J. J. Org. Chem. 2012, 77, 3348-3364. A Dieckmann cyclization route to piperazine-2,5-diones. Larrivée Aboussafy, C.; Clive, D.L.J. J. Org. Chem. 2012, 77, 5125-5131. Reagent for Divalent Sulfur Protection: Preparation of 4-Methylbenzene-sulfonothioic Acid, S-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl] Ester. Wang, L.; Clive, D.L.J. Org. Synth. 2013, 90, 10-24. The Marine Alkaloid Halichlorine — Its Defenses and its Defeat. Clive, D.L.J. In Strategies and Tactics in Organic Synthesis; Harmata, M., Ed.; Vol. 8, Academic Press: Burlington, 2012, pp 25-54. Racemic Marinopyrrole B by Total Synthesis. Cheng, P.; Clive, D.L.J.; Fernandopulle, S.; Chen, Z. Chem. Commun. 2013, 49, 558-560. Synthetic studies on CP-225,917 and CP-263,114: Access to advanced tetracyclic systems by intramolecular conjugate displacement and [2,3]-Wittig rearrangement. Malihi, F.; Clive, D.L.J.; Chang, C.-C.; Minaruzzaman J. Org. Chem. 2013, 78, 996-1013. Asymmetric synthesis of carbocycles: use of intramolecular conjugate displacement. Sreedharan, D.T.; Clive, D.L.J. Org. Biomol. Chem. 2013, 11, 3128-3144. The Marinopyrroles. Clive, D.L.J.; Cheng, P. Tetrahedron 2013, 69, 5067-5078. A General Synthesis of 1,3'-Bipyrroles. Cheng, P.; Shao, W.; Clive, D.L.J. J. Org. Chem. 2013, 78, 11866-11873. Synthesis of substituted resorcinol monomethyl ethers from 2-bromo-3-methoxycyclohex-2-en-1-ones. Shao, W.; Clive, D. L. J. J. Org. Chem. 2015, 80, 3211-3216.