何旺 - 中山大学 - 孙逸仙纪念医院

个人简介

何旺，主治医师，博士，毕业于中山大学，现为中山大学孙逸仙纪念医院泌尿外科硕士研究生导师

研究领域

1）发现新型非编码RNA分子促进膀胱癌淋巴结转移的分子机制。首次发现长链非编码RNA linc-UBC1表达与膀胱癌患者淋巴转移及预后相关。我们在102例膀胱癌组织标本中检测linc-UBC1表达发现，linc-UBC1过表达与膀胱癌淋巴结转移相关，随访结果表明linc-UBC1过表达患者无转移生存及总生存率均下降。研究提示linc-UBC1有希望作为预测预后的分子指标，筛查出高危患者进行更积极的治疗。提出并证实linc-UBC1通过结合PRC2复合物并调控组蛋白H3K27甲基化修饰调控下游基因表达的分子机制。 2）发现长链非编码RNA lncRNA-UNMIBC过表达与膀胱癌复发相关。通过研究发现膀胱癌组织中lncRNA-UNMIBC过表达的患者，术后将更容易复发，其机制可能是通过与染色质修饰复合物结合调控下游靶基因组蛋白修饰和表达，进而影响肿瘤的细胞周期调控。非浸润性膀胱癌术后复发率较高，该研究结果对于筛选高复发风险患者进行个体化膀胱灌注治疗提供了理论依据。

近期论文

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1. He W#, Cai Q#, Sun F, Zhong G, Wang P, Liu H, Luo J, Yu H, Huang J*, Lin T*, linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer, Biochim Biophys Acta-Molecular Basis of Disease, 1832 (2013) 1528-1537. （IF:4.88) 2. Chen C#, Cai Q#, He W#, Li Z, Zhou F, Liu Z, Zhong G, Chen X, Zhao Y, Dong W, Huang J, Zheng J, Lin T.An NKX3.1 binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancer. Int J Cancer;2016, 138(1):74-86,（IF:5.08) 3. Zhang S#, Zhong G#, He W#, Yu H, Huang J, Lin T. LncRNA Up-Regulated in Nonmuscle Invasive Bladder Cancer Facilitates Tumor Growth and Acts as a Negative Prognostic Factor of Recurrence. J Urol. 2016, 196(4):1270-8 （IF:4.47) 4. Luo XL#, He W#, Huang H, Chen QY, Liang Y, Mai HQ, Huang HQ, Cai QQ*. Design of a prognostic score model for nasopharyngeal carcinoma. Head Neck. 2015, 37(5):624-9, （IF:2.64) 5. Zhao F#, Lin T#, He W, Han J, Zhu D, Hu K, Li W, Zheng Z, Huang J, Xie W*. Knockdown of a novel LincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer. Oncotarget. 2014 Nov 25. [Epub ahead of print] PMID: 25473900 6. Luo J, Cai Q, Wang W, Huang H, Zeng H, He W, Deng W, Yu H, Chan E, Ng CF, Huang J, Lin T. A microRNA-7 binding site polymorphism in HOXB5 leads to differential gene expression in bladder cancer. PLoS One. 2012;7(6):e40127 7. Chen X, Xie W, Gu P, Cai Q, Wang B, Xie Y, Dong W, He W, Zhong G, Lin T, Huang J. Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation. Sci Rep. 2015,6;5:8293. 8. Wang B, Wu S, Zeng H, Liu Z, Dong W, He W, Chen X, Dong X, Zheng L, Lin T, Huang J. CD103+Tumor Infiltrating Lymphocytes Predict a Favorable Prognosis in Urothelial Cell Carcinoma of the Bladder. J Urol. 2015 Aug;194(2):556-62. 9. Xu XL, Yang HY, Ou B, Lin SD, Wu H, He W, Jiang QC, Luo BM, Li GP. Int J Oncol. 2015,46(5):2138-42.Hydroxyapatite nanoparticles modified by branched polyethylenimine are effective non-viral vectors for siRNA transfection of hepatoma cells in vitro. Int J Oncol. 2015;46(5):2138-42. 10. Huang L, Peng Y, Zhong G, Xie W, Dong W, Wang B, Chen X, Gu P, He W, Wu S, Lin T, Huang J. PBRM1 suppresses bladder cancer by cyclin B1 induced cell cycle arrest. Oncotarget. 2015;6(18):16366-78. 11. Peng Y, Dong W, Lin TX, Zhong GZ, Liao B, Wang B, Gu P, Huang L, Xie Y, Lu FD, Chen X, Xie WB, He W, Wu SX, Huang J.MicroRNA-155 promotes bladder cancer growth by repressing the tumor suppressor DMTF1. Oncotarget. 2015;6(18):16043-58.