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个人简介

2015.7-至今 助理教授 厦门大学公共卫生学院 2012.8-2013.3 访问学者 哈佛大学医学院布里格姆妇女医院,美国波士顿 2008.9-2014.12 博士 生物化学与分子生物学专业,生命科学学院,厦门大学

研究领域

溶瘤病毒与肿瘤治疗 原发性肝癌治疗的新技术及新靶点研究 肿瘤的免疫调节及免疫治疗研究 乙型肝炎病毒HBx蛋白致癌机制研究

近期论文

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(1)Yi Y. F.#, Huang C. H. #, Zhang Y. M. #, Tian S. K., Lei J. X., Chen S. L., Shi G. G., Wu Z. D., Xia N. S., Zhong S. P.*. Exploring a common mechanism of alcohol-induced deregulation of RNA Pol III genes in liver and breast cells[J]. Gene, 2017, 626: 309–318. (#共一作者) (2)Lin, C. L., Li, H. H., Hao, M. R., Xiong, D., Luo, Y., Huang, C. H. *, Yuan, Q., Zhang, J., Xia, N. S.*. Increasing the Efficiency of CRISPR/Cas9-mediated Precise Genome Editing of HSV-1 Virus in Human Cells [J]. Sci Rep, 2016, 7(6):34531. (*共通讯作者) (3)Luo, Y. #, Xiong, D. #, Li, H. H., Qiu, S. P., Lin, C. L., Chen, Q., Huang, C. H. *, Yuan, Q., Zhang, J., Xia, N. S.*. Development of an HSV-1 neutralization test with a glycoprotein D specific antibody for measurement of neutralizing antibody titer in human sera[J]. Virol J, 2016, 13(44). (*共通讯作者) (4)Huang, C. H. #, Yuan, Q. #, Chen, P. J., Zhang, Y. L., Chen, C. R., Zheng, Q. B., Yeh, S. H., Yu, H., Xue, Y., Chen, Y. X., Liu, P. G., Ge, S. X., Zhang, J. and Xia, N. S.*. Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors[J]. J Hepatol, 2012, 57(4): 720-9. (#共一作者) (5)Geng, X. #, Huang, C. H.#, Qin, Y., McCombs, J. E., Yuan, Q., Harry, B. L., Palmer, A. E., Xia, N. S.* and Xue, D.*. Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction[J]. Proc Natl Acad Sci U S A, 2012, 109(45): 18471-6. (#共一作者) (6)Yuan, Q., Ou, S. H., Chen, C. R., Ge, S. X., Pei, B., Chen, Q. R., Yan, Q., Lin, Y. C., Ni, H. Y., Huang, C. H., Yeo, A. E., Shih, J. W., Zhang, J. and Xia, N. S. Molecular characteristics of occult hepatitis B virus from blood donors in southeast China[J]. J Clin Microbiol, 2010, 48(2): 357-62. (7)Yuan, Q., Song, L. W., Liu, C. J., Li, Z., Liu, P. G., Huang, C. H., Yan, Y., Ge, S. X., Wang, Y. B., Peng, C. Y., Zhang, J., Kao, J. H., Chen, D. S., Chen, P. J. and Xia, N. S. Quantitative hepatitis B core antibody level may help predict treatment response in chronic hepatitis B patients[J]. Gut, 2013, 62(1): 182-4.

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