罗文新 - 厦门大学 - 公共卫生学院

个人简介

教育和工作经历 2004年-今，厦门大学生命科学学院副教授 2003年，厦门大学海洋系海洋生物学专业，博士学位 1996-2003年，厦门大学海洋系，助理教授 1996年，厦门大学生物系微生学专业，硕士学位

研究领域

近年来在抗体药物研发领域进行了较为深入的研究, 围绕基于治疗抗体药物研发的关键技术环节，初步建立了一个从全人抗体筛选、抗体分子改造到抗体表达生产工艺和成药性评估的抗体药物开发技术平台，从而推进基础研究中获得的创新性治疗性抗体向产业化转化。在此平台上已完成具有治疗潜力的抗HBV抗体的分子改造和成药性评估，获得的临床候选分子将进入产业化实施阶段。

近期论文

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1.Xia L, Zhang J, Cui C, Bi X, Xiong J, Yu H, An Z, Luo W*, Xia N. In vitro affinity maturation and characterization of anti-P24 antibody for HIV diagnostic assay. J Biochem. 2015 Jul 9. pii: mvv070 2.Tao Jiang, Daiping Guo, Qian Wang, Xin Wu, Zhao Li, Zhenhua Zheng, Boyuan Yin, Lin Xia, Jixian Tang, Wenxin Luo, Ningshao Xia, Yunbao Jiang. Developing a Genetically Encoded Green Fluorescent Protein Mutant for Sensitive Light-up Fluorescent Sensing and Cellular Imaging of Hg(II). Anal Chim Acta. 2015，876: 77-82 3.You M, Xin L, Yang Y, Zhang X, Chen Y, Yu H, Li S, Zhang J, An Z, Luo W*, Xia N. Investigation of a special neutralizing epitope of HEV E2s. Protein Cell. 2014 Dec;5(12):950-3. 4.You M, Liu Y, Chen Y, Guo JY, Wu J, Fu Y, Shen R, Qi R, Luo W*, Xia N. Maximizing antibody production in suspension-cultured mammaliancells by customized transient gene expression method. Biosci. Biotech. Bioch, 77(6):1207-1213,2013. 5.Chen Y, Luo W*, Song H, Yin B, Tang J, Chen Y, Ng MH, Yeo A, Zhang J, Xia N*. Mimotope ELISA for Detection of Broad Spectrum Antibody against Avian H5N1 Influenza Virus. Plos One. 6(9): e24144, 2011 6.Zheng Q, Xia L, Wu WL, Zheng Z, Huo Y, Wu J, Liu Y, Yu H, Chen Y, Lau SY, Chen H*, Luo W*, Xia N. Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses. Antimicrob Agents Chemother. 55(4):1349-1357, 2011 7.Zheng Z, Luo W*, Song H, Chen Y, Xiong J, Chen Y, Gu Y, Chen H, Shih JW, Zhang J, Xia N. Antibody reactivity of conformational peptide mimics of a conserved H5N1 neutralization site in different fusion proteins. Arch Virol. 155(1):19-26, 2010 8.Song H, Luo W*, Chen Y, Du H, Tang J, Yin B, ChenY, Shi JW, Zhang J. Induction of cross-reactive antibodies against mimotopes of H5N1 hemagglutinin. Vet. Microbiol, 145(1-2):17-22, 2010 9.Chen Y, Luo W*, Wu WL, Fang Z, Xia L, Gui X, Chen Y, Chen H, Shih JW, Xia N*. Humanized antibodies with broad-spectrum neutralization to avian influenza virus H5N1.Antiviral Res. 87(1):81-88, 2010 10.Luo W*, Chen Y, Wang M, Chen Y, Zheng Z, Song H, Chen H, Guan Y, Ng MH, Zhang J, Xia N. Peptide mimics of a conserved H5N1 avian influenza virus neutralization site. Biochem J. 419:133-139, 2009 11.Luo W, Chen Y, Li L, Xu C, Miao J, Shih JW, Zhang J, Xia N. Construction and characterization of the chimeric antibody 8C11 to the hepatitis E virus. FEMS Immunol Med icrobiol. 51(1):18-25, 2007 12.Chen Y, Luo W, Wang M, Wang J, Li L, Yuan Q, Zhang J, Xia N. Isolation of human antibodies against hepatitis E virus from phage display library by immobilized metal affinity chromatography. Biomedical and Environmental Sciences 2007. 20:488-494. 13.Fang Z, Luo W, Wang M, Chen Y, Zhang J, Chen H, Guan Y, Xia N. Preparation and Identification of a Single-chain Antibody Fragment Against High Pathogenic H5N1Avian Influenza Virus. Chin J Biotech, 2007, 23(2), 292−296 14.Luo W, Cheng T, Guan B, Li S, Zhang J, Xia N. Variants of Green Fluorescent Protein GFPxm. Marine Biotech. 8:560-566, 2006