朱正茂 - 南开大学 - 生命科学学院

个人简介

朱正茂，南开大学生命科学学院副教授，硕导，已在Nature Communications、PNAS、Cell Research、Breast Cancer Research、Animal Genetics等杂志上发表论文40余篇。现研究目标是阐明核膜与内质网膜稳态调控机制及其对衰老发生和肿瘤恶性演进的关键影响。教育经历1994年9月-1998年7月，华中农业大学动物科学与动物医学学院学习，专业：动物科学，获农学学士学位。 1998年9月-2003年12月，华中农业大学动物科学与动物医学学院学习，专业：动物遗传育种与繁殖，获农学博士学位。工作经历2004年1月-2004年12月，中国农业科学院北京畜牧兽医研究所,助理研究员。 2005年1月-2007年3月，中国农业科学院北京畜牧兽医研究所,博士后，副研究员。 2007年3月至今，在南开大学生命科学学院遗传与细胞生物学系任职，副教授。

研究领域

（1）核膜稳态调控异常致基因组失稳的分子机制（2）内质网细胞器稳态异常致衰老发生的分子机制（3）乳腺肿瘤和卵巢癌的致病基因及其作用分子机制

近期论文

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1. Ang Gao, Tonghua Sun, Gui Ma, Jiangran Cao, Qingxia Hu, Ling Chen, Yanxin Wang, Qianying Wang, Jiafu Sun, Rui Wu, Qiao Wu, Jiaxi Zhou, Lin Liu, Junjie Hu*, Jintang Dong*, Zhengmao Zhu*(2018) LEM4 confers tamoxifen resistance to breast cancer cells by activating cyclin D-CDK4/6-Rb and ERa pathway. Nature Communications 2. Wu Y, Li X, Jia J, Zhang Y, Li J, Zhu Z, Wang H, Tang J, Hu J* (2018) Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL. Proc Natl Acad Sci U S A 115: E2762-E2771 3. Luo A, Zhang X, Fu L, Zhu Z, Dong JT* (2016) Zinc finger factor ZNF121 is a MYC-interacting protein functionally affecting MYC and cell proliferation in epithelial cells. J Genet Genomics 43: 677-685 4. Zhang B, Zhao R, He Y, Fu X, Fu L, Zhu Z, Fu L, Dong JT* (2016) MicroRNA 100 sensitizes luminal A breast cancer cells to paclitaxel treatment in part by targeting mTOR. Oncotarget 7: 5702-5714 5. Wu Q, Zhang L, Su P, Lei X, Liu X, Wang H, Lu L, Bai Y, Xiong T, Li D, Zhu Z, Duan E, Jiang E, Feng S, Han M, Xu Y, Wang F, Zhou J* (2015) MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling. Cell research 25: 1314-1332 6. Zhao H, Gao A, Zhang Z, Tian R, Luo A, Li M, Zhao D, Fu L, Dong JT, Zhu Z*: Genetic analysis and preliminary function study of miR-423 in breast cancer. Tumour Biol 2015, 36(6):4763-4771. 7. Zhang ZQ, Zhu ZM, Zhang BT, Li WD, Li X, Wu X, Wang LJ, Fu LY, Fu L, Dong JT*: Frequent Mutation of rs13281615 and Its Association with PVT1 Expression and Cell Proliferation in Breast Cancer. Journal of Genetics and Genomics 2014, 41(4):187-195. 8.Zhang M, Wu F, Shi J, Zhu Y, Zhu Z, Gong Q, Hu J*: ROOT HAIR DEFECTIVE3 family of dynamin-like GTPases mediates homotypic endoplasmic reticulum fusion and is essential for Arabidopsis development. Plant Physiol 2013, 163(2):713-720. 9.Wu X, Zhu Z*, Li W, Fu X, Su D, Fu L, Zhang Z, Luo A, Sun X, Dong JT*: Chromodomain helicase DNA binding protein 5 plays a tumor suppressor role in human breast cancer. Breast Cancer Res 2012, 14(3):R73. 10.Su D, Fu X, Fan S, Wu X, Wang XX, Fu L, Dong XY, Ni JJ, Zhu Z*, Dong JT*: Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells. Am J Pathol 2012, 180(3):1189-1201. 11.Zhang Z, Zhang B, Li W, Fu L, Zhu Z*, Dong JT*: Epigenetic Silencing of miR-203 Upregulates SNAI2 and Contributes to the Invasiveness of Malignant Breast Cancer Cells. Genes Cancer 2011, 2(8):782-791. 12.Dong X, Liu F, Sun L, Liu M, Li D, Su D, Zhu Z, Dong JT, Fu L, Zhou J*: Oncogenic function of microtubule end-binding protein 1 in breast cancer. J Pathol 2010, 220(3):361-369. 13.Chen L, Zhu Z, Sun X, Dong XY, Wei J, Gu F, Sun YL, Zhou J, Dong JT, Fu L*: Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis. Breast Cancer Res Treat 2009, 116(3):471-478. 14.Zhu Z, Li Y, Mo D, Li K, Zhao S*: Molecular characterization and expression analysis of the porcine caveolin-3 gene. Biochem Biophys Res Commun 2006, 346(1):7-13. 15.Zhu ZM, Zhang JB, Li K, Zhao SH*: Cloning, mapping and association study with carcass traits of the porcine SDHD gene. Anim Genet 2005, 36(3):191-195.