杨军 - 南开大学 - 生命科学学院

个人简介

近年着眼于融合生物学、材料学及生物工程学的原理与技术，开发基因工程生物合成生物活性材料及其与天然多糖的复合材料，研究三维仿生细胞外微环境构建的基本原理与技术；进一步揭示细胞与材料之间的相互作用和体内外诱导组织再生的调控规律及其分子机制；探索工程化干细胞、肝/血管组织工程材料在再生医学领域的应用研究。正在主持及完成国家和天津市自然科学基金共计8项，参加“十三五”生物材料重点研发专项1项，参与完成863/973项目3项；发表SCI源学术期刊研究论文40余篇，申报发明专利7项（已获授权5项），医用材料导论（原著第2版）-中文版翻译及材料大辞典（第2版）生物医用材料编委会委员。教育经历 1997/05-2001/09，日本东京工业大学生命理工学科生物技术专业，博士 1994/09-1997/03，天津大学应用化学系高分子材料专业硕士 1986/09-1990/07，天津大学应用化学系高分子化工专业学士工作经历 1. 2005/12-至今南开大学生命科学学院生物活性教育部重点实验室教授博士生导师 2. 2003/10-2005/03 日本国立医药品食品卫生研究所医疗用品部厚生省特别研究员 3. 2001/10-2003/09，日本国立医药品食品卫生研究所医疗用品部 JSPS博士后 4. 1990/08-1994/08年天津市第三中心医院肝胆疾病研究所实习研究员

研究领域

生物活性材料调控干细胞增殖与分化的研究工程化组织构建调控机制与关键技术研究用于药物研发的组织模型及再生医学产品研发

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Lei Cao, Yan Zhang, Mengyuan Qian, Xueping Wang, Qizhi Shuai, Chao Gao, Ren Lang, Jun Yang*. Construction of multicellular aggregate by E-cadherin coated microparticles enhancing the hepatic specific differentiation of mesenchymal stem cells. Acta Biomaterialia, 2019, doi.org/10.1016/j.actbio.2019.01.030 Ke Xu, Chuanshun Zhu, Jinghui Xie, Xiaoning Li, Yan Zhang*, Fanglian Yao, Zhongwei Gu, Jun Yang*. Enhanced vascularization of porous scaffolds through VEGF-Fc modification. J Mater. Chem B., 2018,6,4474-4485. Ningning He, Xiaoniao Chen, Dan Wang, Ke Xu, Lingling Wu, Yuanyuan Liu, Hongyan Tao, Qinjun Zhao, Xiaocang Cao, Yuhao Li, Na Liu, Xin Qi, Zhongchao Han, Deling Kong, Jun Yang*, Zongjin Li*. VE-Cadherin regulates the self-renewal of mouse embryonic stem cells via LIF/Stat3 signaling pathway. Biomaterials, 2018, 158 (1), 34-43. Ke Xu, Qizhi Shuai, Xiaoning Li, Yan Zhang, Chao Gao, Lei Cao, Feifei Hu, Toshihiro Akaike, Jianxi Wang, Zhaongwei Gu, Jun Yang*. Human VE-cadherin fusion protein as an artificial extracellular matrix enhancing the proliferation and differentiation functions of endothelial cell. Biomacromolecules, 2016,17 (3),756-766. (Editor’s choice, ASC 2016) Yan Zhang, Hongli Mao, Chao Gao, Suhua Li, Qizhi Shuai, Jianbin Xu, Ke Xu, Lei Cao, Ren Lang*, Toshihiro Akaike, Jun Yang*. Enhanced biological functions of human mesenchymal stem cell aggregates incorporating E-cadherin-modified PLGA microparticles. Adv Healthc Mater, 2016, 15(5) :1949-1959. Yan Zhang, Hongli Mao, Mengyuan Qian, Feifei Hu, Lei Cao, Ke Xu, Qizhi Shuai, Chao Gao, Ren Lang, Toshihiro Akaike, Jun Yang*. Surface modification with E-cadherin fusion protein for mesenchymal stem cell culture. J Mater. Chem B, 2016, 24(4):4237-4368. (Hot Paper, JMCB 2016) 张妍许可高超杨军基于融合蛋白的生物材料及其在组织工程中的应用中国材料进展 2015, 34(3):204-215. Jianbin Xu, Suhua Li, Feifei Hu, Chuanshun Zhu, Yan Zhang, Wei Zhao, Toshihiro Akaike and Jun Yang*. Artificial biomimicking matrix modifications of nanofibrous scaffolds by hE-cadherin-Fc fusion protein to promote human mesenchymal stem cells adhesion and proliferation. Journal of Nanoscience and Nanotechnology 2014,14(6):4007-13. Jinbin Xu, Chuanshun Zhu, Yan Zhang, Nan Jiang, Suhua Li, Zhongyu Su, Toshihiro Akaike, Jun Yang*. hE-cadherin-Fc fusion protein coated surface enhances the adhesion and proliferation of human mesenchymal stem cells. Colloids and surfaces B: Biointerfaces 2013,109 :97-102. Yi Shang, Miho Tamai, Ryusei Ishii, Noriyuki Nagaoka, Yasuhiro Yoshida, Masamichi Ogasawara, Jun Yang and Yohichi Tagawa. Hybrid sponge comprised of galactosylated chitosan and hyaluronic acid mediates the co-culture of hepatocytes and endothelial cells. Journal of Bioscience and Bioengineering 2014, 117:99-106. Xu Jinbin, Zhang Yan, Li Suhua, Yao Fanglian, Akaike Toshihiro, YangJun*. Human E-cadherin-Fc fusion protein matrix improving the hepatic differentiation of human mesenchymal stem cells. Chinese Journal of Biomedicial Engineering 2013, 32(6):27-34. Yu Meihua, Du Fengyi, Rao Xia, Yao Fanglian, Yang Jun*. Effects of artificial extracellular matrixes on the survival of vascular endothelial cells. Chemical Journal of Chinese Universities 2013,34(3):736-750. Meihua Yu, Fengyi Du, Hirohiko Ise, Wei Zhao, Yan Zhang, Yaoting Yu, Fanglian Yao, Jun Yang*, Toshihiro Akaike. Preparation and characterization of a VEGF-Fc fusion protein matrix for enhancing HUVEC growth. Biotechnol. Lett. 2012,34:1765-1771. Fengyi Du, Hao Wang, Deling Kong, Jun Yang* and Yuanyuan Zhang. Gradient functional nanofibrous scaffolds as extracellular microenvironments for vascular tissue engineering. Biomaterials 2012,33:762-770。