宁文 - 南开大学 - 药物化学生物学国家重点实验室

个人简介

学科方向药物标靶的疾病分子机制研究宁文教授，南开大学生命科学学院教授。1988年毕业于南京大学生物系，获学士学位。1994年毕业于南京大学生物系，获博士学位。毕业后留校并聘为副教授。1997-1998在香港科技大学生物系做访问学者。2000-2005年在美国Pittsburgh 大学医学中心做博士后，主要从事吸烟与肺损伤和吸烟引起慢性阻塞性肺疾病(COPD)的分子机制的研究。在国际学术刊物上发表论文14篇，其中以第一作者发表9篇。2005年回国，受聘为南京大学模式动物研究所教授。2008年8月后受聘为南开大学生命科学院教授。2006年入选教育部新世纪优秀人才计划，现主持国家自然基金和科技部973等课题项目。目前主要研究内容为：1)利用Fstl1基因全身敲除小鼠模型和各种Fstl1基因诱导型定向敲除小鼠模型，研究早期肺发育的过程和肺干细胞定向分化为各种肺上皮细胞的机制。2）建立多种肺疾病（如：肺纤维化；哮喘和急性肺损伤）动物模型，以Fstl1为切入点研究多种信号通路在损伤发生过程中的调控机制。3）纤维化疾病抗体药物或小分子药发现。

研究领域

1. 肺发育 2. TGFb/BMP4信号通路在慢性肺纤维化疾病中作用机制； 3. 肿瘤微环境与肿瘤细胞转移的分子机制； 4. 癌症和慢性纤维增生性疾病的小分子药物发现

近期论文

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1. Yingying Dong, Yan Geng, Lian Li, Xiaohe Li, Xiaohua Yan, Yinshan Fang, Xinxin Li, Siyuan Dong, Xue Liu, Xue Li, Xiuhong Yang, Xiaohong Zheng, Ting Xie, Jiurong Liang, Huaping Dai, Xinqi Liu, Zhinan Yin, Paul Noble, Dianhua Jiang* and Wen Ning* . Blocking Follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice. J Exp Med, 2015. 212(2): 235-252 (*, corresponding author) 2. Yan Geng, Lian Li, YingYing Dong, Xue Liu, Xiaohe Li, Wen Ning*. Impaired Elastin Deposition in Fstl1–/– Lung Allograft under the Renal Capsule. PLoS ONE, 2013, 8(11): e81368 (*, corresponding author) 3. Lian Li, Xinxin Li, Xue Liu, Yingying Dong, Yan Geng, Xinqi Liu*, Wen Ning* Expression, characterization, and preliminary X-ray crystallographic analysis of recombinant murine Follistatin-like 1 expressed in Drosophila S2 cells. BioScience Trends. 2013; 7(2):93-100. (*, corresponding author) 4. Yan Geng, Yingying Dong, Mingyan Yu, Long Zhang, Xiaohua Yan, Jingxia Sun, Long Qiao, Huixia Geng, Masahiro Nakajima, Tatsuya Furuichi, Shiro Ikegawa, Xiang Gao, Ye-Guang Chen*, Dianhua Jiang*, and Wen Ning*. Fstl1 Is a BMP4 Signaling Antagonist in Controlling Mouse Lung Development. Proc Natl Acad Sci U S A.. 2011 108(17):7058-7063 (*, corresponding author) 5. Ning Shen, Tao Gong, Jian-Dong Wang, Fan-Li Meng, Long Qiao, Run-Lin Yang, Bin Xue, Fei-Yan Pan, Xiao-Jun Zhou, Hua-Qun Chen, Wen Ning*, Chaojun Li*. Cigarette Smoke–Induced Pulmonary Inflammatory Responses Are Mediated by EGR-1/GGPPS/MAPK Signaling. Am. J. Pathol. 2011 178(1): 110-118. (*, corresponding author) 6. Ning W, Li CJ, Feghali-Bostwick CA, Matthay MA Choi AM. MAPK-EGR-1-HSP70 pathway regulates cigarette smoke induced chemokine release in human lung fibroblasts.Am J Physiol Lung Cell Mol Physiol. 2007 292(5):L1297-303 7. Ning W, Dong Y, Sun J, Li CJ, Feghali-Bostwick CA, Matthay MA Choi AM. Cigarette Smoke Stimulates Matrix Metalloproteinase Activity via EGR-1 in Human Lung Fibroblasts. Am J Respir. Cell Mol. Biol. 2007 36(4):480-90. 8. Ning W, Peters DG, Chu TJ, Li C, Choi AM. Comparative SAGE Analysis of the Response to Hypoxia in Human Pulmonary and Aortic Endothelial Cells. Physiol Genomics. 2006 26(2):99-108 9. Ning W, Choi AM Li C. Carbon monoxide inhibits IL-17-induced IL-6 production through the MAPK pathway in human pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2005;289(2):L268-73. 10. Wen Ning, Chao-Jun Li and Augustine M.K. Choi. Global Gene Expression Profiles Reveal Pathways Related to the Pathogenesis of Chronic Obstructive Pulmonary Disease. (2005) Discovery Medicine 5(25) :88-93 11. Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP, Otterbein SL, Song R, Hayashi S, Zhou Z, Pinsky DJ, Watkins SC, Pilewski JK, Sciurba FC, Peters DG, Hogg JC, Choi AM. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2004 ;101(41):14895-900.) 12. Ning W, Chu TJ, Li CJ, Choi AM, Peters DG. Genome-wide analysis of the endothelial transcriptome under short-term chronic hypoxia. Physiol Genomics. 2004 ;18(1):70-8. 13. Ning W, Song R, Li C, Park E, Mohsenin A, Choi, Choi ME. TGF-beta1 stimulates HO-1 via the p38 mitogen-activated protein kinase in A549 pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2002 ;283(5):L1094-102.