李磊 - 南开大学 - 生命科学学院

个人简介

教育经历 2009-2013年于澳大利亚西澳大学获得植物生物化学博士学位工作经历 2012.11-2018.9任澳大利亚植物能源中心（ARC Centre of Excellence in Plant Energy biology）助理研究员

研究领域

我们课题组主要利用生物化学，质谱蛋白质组学和细胞生物学等技术手段进行植物线粒体和叶绿体蛋白质稳态调控的研究。蛋白质周转率即蛋白的合成和降解循环是生物细胞内重要的能量消耗过程，蛋白质周转率研究是蛋白质组学研究的新热点，单个蛋白质分子合成和降解速率及其耗能测定平台的建立为回答：mRNA和其所翻译蛋白丰度不匹配，蛋白水解酶和自噬选择性降解途径调控，线粒体和叶绿体功能受损引发的植物生长和发育受损及衰老机制等一系列生物学问题提供了新的思路。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Li, L, Aro E-M, Millar AH (2018) Mechanisms of Photodamage and Protein Turnover in Photoinhibition. Trends in plant science 10.1016/j.tplants.2018.05.004 2. Li L, Nelson CJ, Trosch J, Castleden I, Shaobai H, Millar AH (2017) Protein degradation rate in Arabidopsis thaliana leaf gowth and development. The Plant Cell 10.1105/tpc.16.00768 F1000 Recommendations http://f1000.com/prime/727254556?bd=1 Research Highlight by ARC http://www.arc.gov.au/teaching-plants-be-better-spenders Altmetric Attention score is No.1 of 54 similar age publications in The Plant Cell; and TOP 1% over nearly 2400 outputs from The Plant Cell https://plant.altmetric.com/details/15980303#score 3. Li L, Nelson CJ, Trosch J, Pruzinska A, Millar AH and Shaobai Huang (2016)Changes in specific protein turnover in Arabidopsis reveal multiple roles of Lon1 in mitochondrial protein homeostasis The Plant Journal 89 (3): 458-471 Media Release https://www.scimex.org/newsfeed/unravelling-the-role-of-plant-growth-protein-could-provide-clues-for-human-health 4. Li L, Nelson CJ, Solheim C, Whelan J, Millar AH (2012) Determining degradation and synthesis rates of arabidopsis proteins using the kinetics of progressive 15N labeling of two-dimensional gel-separated protein spots. Mol Cell Proteomics 11: M111 010025 5. Li L, Nelson CJ, Carrie C, Gawryluk R, Solheim C, Gray MW, Whelan J, Millar AH(2013) Subcomplexes of ancestral respiratory complex I subunits rapidly turn over in vivo as producible assembly intermediates in Arabidopsis. J Biol Chem 288: 5707-5717 6. Li L, Carrie C, Nelson C, Whelan J, Millar AH (2012) Accumulation of Newly Synthesized F1in vivo in Arabidopsis Mitochondria Provides Evidence for Modular Assembly of the Plant F1Fo ATP Synthase. J Biol Chem 287: 25749-25757 7. Li L, Millar AH and Shaobai Huang (2017)Mitochondrial Lon1 has a role in homeostasis of the mitochondrial ribosome and pentatricopeptide repeat proteins in plants. Plant Signaling&Behavior 12(2): e1276686 8. Solheim C,Li L, Hatzopoulos P, Millar AH (2012) Loss of Lon1 in Arabidopsis changes the mitochondrial proteome leading to altered metabolite profiles and growth retardation without an accumulation of oxidative damage. Plant Physiol 160: 1187-1203 9. Huang S, Nelson CJ,Li L, Taylor NL, Stroher E, Peteriet J, Millar AH (2015) INTERMEDIATE CLEAVAGE PEPTIDASE55 Modifies Enzyme Amino Termini and Alters Protein Stability in Arabidopsis Mitochondria. Plant Physiol 168: 415-427 10. Huang S, Jacoby RP, Shingaki-Wells RN,Li L, Millar AH (2013) Differential induction of mitochondrial machinery by light intensity correlates with changes in respiratory metabolism and photorespiration in rice leaves. New Phytol 198: 103-115 11. Jacoby RP,Li L, Huang S, Lee CP, Millar AH, Taylor NL (2012) Mitochondrial Composition, Function and Stress Response in Plants. J Integr Plant Biol 54(11): 887-906 12. Nelson CJ, Li L, Jacoby RP, Millar AH (2013) Degradation rate of mitochondrial proteins in Arabidopsis thaliana cells. J Proteome Res 12: 3449-3459 13.Nelson CJ,Li L, Millar AH(2013) Quantitative analysis of protein turnover in plants. Proteomics 12: 3449-3459 14.Simmons LW, Beveridge M, Li L, Tan YF, Millar AH (2014) Ontogenetic changes in seminal fluid gene expression and the protein composition of cricket seminal fluid. Evolution & Development 16: 101-109