陈凌懿 - 南开大学 - 药物化学生物学国家重点实验室

个人简介

学科方向药物标靶的疾病分子机制研究陈凌懿教授，南开大学生命科学学院教授。1999.7北京大学生物化学与分子生物学专业，获得学士学位，2004.12美国西北大学生物化学专业，获得博士学位，2005.1—2008.1美国哈佛大学博士后，2009.4--至今南开大学生命科学学院教授、博导。研究方向：胚胎干细胞多能性维持的分子机制；小鼠早期胚胎发育的分子调控调控制；家族性甲状腺肿瘤的致病基因和机理。陈凌懿教授的研究目标是阐明胚胎干细胞多能性维持和分化，以及早期胚胎发育中的转录编程的调控机制。受精卵可以从一个细胞通过分裂和分化形成机体中的所有类型的细胞。同一机体的所有细胞中基因组DNA携带的遗传物质都相同，但不同细胞对遗传信息的解读方式（即转录编程）不同，从而导致基因表达谱、细胞表型和命运的差异。转录因子、表观遗传修饰、非编码RNA和信号传导通路都参与了转录编程的调控。陈凌懿教授关注在多能细胞自我更新和分化过程中（包括胚胎干细胞的自我更新和分化；受精卵发育到囊胚，然后形成原始三胚层）转录编程的调控机制。此外，陈凌懿教授还对家族性甲状腺肿瘤的遗传机制进行研究，以期找出其致病基因，并阐明这些致病基因在甲状腺肿瘤发生、发展中以及正常甲状腺发育中的作用。

研究领域

维持胚胎干细胞多能性的分子机制; 早期胚胎中内细胞团和滋养层细胞分化的分子机制.

近期论文

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1. Ruan X, Shi X, Dong Q, Yu Y, Hou X, Song X, Wei X, Chen L*, Gao M.* (2019) Antitumor effects of anlotinib in thyroid cancer. Endocr Relat Cancer, 26:153-164. 2. Ha N, Lai LT, Chelliah R, Zhen Y, Yi Vanessa SP, Lai SK, Li HY, Ludwig A, Sandin S, Chen L*, Zhang LF.* (2018) Live-Cell Imaging and Functional Dissection of Xist RNA Reveal Mechanisms of X Chromosome Inactivation and Reactivation. iScience, 8:1-14. 3. Li P, Ding N, Zhang W, Chen L.* (2018) COPS2 Antagonizes OCT4 to Accelerate the G2/M Transition of Mouse Embryonic Stem Cells. Stem Cell Reports, 11:317-324. 4. Li W, Hong R, Lai LT, Dong Q, Ni P, Chelliah R, Huq M, Ismail SNB, Chandola U, Ang Z, Lin B, Chen X, Chen L*, Zhang LF*. (2018) Genome-Wide RNAi Screen Identify Melanoma-Associated Antigen Mageb3 Involved in X Chromosome Inactivation. J Mol Biol, 430:2734-2746. 5. Guallar D, Bi X, Pardavila JA, Huang X, Saenz C, Shi X, Zhou H, Faiola F, Ding J, Haruehanroengra P, Yang F, Li D, Sanchez-Priego C, Saunders A, Pan F, Valdes VJ, Kelly K, Blanco MG, Chen L, Wang H, Sheng J, Xu M, Fidalgo M, Shen X, and Wang J.* (2018) RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells. Nat Genet, 50:443-451. 6. Zhou Z, Wang L, Ge F, Gong P, Wang H, Wang F, Chen L, and Liu, L.* (2018) Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis. Nucleic Acids Res, 46:3468-3486.. 7. Shi X, Yin Z, Ling B, Wang L, Liu C, Ruan X, Zhang W, and Chen L.* (2017) Rho differentially regulates the Hippo pathway by modulating the interaction between Amot and Nf2 in the blastocyst. Development, 144:3957-3967. 8. Yin Z, and Chen L.* (2017). Simple Meets Single: The Application of CRISPR/Cas9 in Haploid Embryonic Stem Cells. Stem Cells Int, 2017:2601746. 9. Yu Y, Liu C, Zhang J, Zhang M, Wen W, Ruan X, Li D, Zhang S, Gao M*, and Chen L.* (2017) Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function.Sci Rep, 7:43396. 10. Liu C, Yu Y, Yin G, Zhang J, Wen W, Ruan X, Li D, Zhang S, Cai W, Gao M*, and Chen L.* (2017) C14orf93 (RTFC) is identified as a novel susceptibility gene for familial nonmedullary thyroid cancer.Biochem Biophys Res Commun, 482:590-596. 11. Ma X, Chen H, and Chen L.* (2016) A dual role of Erk signaling in embryonic stem cells.Exp Hematol, 44:151-156. 12. Zhang W, Ni P, Mou C, Zhang, Y, Guo H, Zhao T, Loh YH*, and Chen L.* (2016) Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription.Sci Rep, 6:26804. 13. Chen H, Guo R, Zhang Q, Guo H, Yang M, Wu Z, Gao S, Liu L*, and Chen L.* (2015) Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. Proc Natl Acad Sci U S A, 112:E5936-5943. 14. Yang BX, El Farran CA, Guo HC, Yu T, Fang HT, Wang HF, Schlesinger S, Seah YF, Goh GY, Neo SP, Li Y, Lorincz MC, Tergaonkar V, Lim TM, Chen L, Gunaratne J, Collins JJ, Goff SP, Daley GQ, Li H, Bard FA, and Loh YH.* (2015) Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells. Cell, 163: 230-245. 15. Liu F, You X, Wang Y, Liu Q, Liu Y, Zhang S, Chen L*, Zhang X*, Ye L.* (2014) The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF. Carcinogenesis, 35:1144-1153. 16. Liu H, Wu Z, Shi X, Li W, Liu C, Wang D, Ye X, Liu L, Na J*, Cheng H*, Chen L*. (2013) Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryo compaction. Dev Biol, 375:13-22. 17. Wu Z, Yang M, Liu H, Guo H, Wang Y, Cheng H, Chen L*. (2012) Role of Nuclear Receptor Coactivator 3 (Ncoa3) in Pluripotency Maintenance. Journal of Biological Chemistry, 287:38295-38304. 18. Chen L*, Wang D, Wu Z, Ma L, and Daley G.Q.* (2010) Molecular basis of the first cell fate determination in mouse embryogenesis.Cell Res, 20:982-993. 19. Chen L, Yabuuchi A, Eminli S, Takeuchi A, Lu C. W, Hochedlinger K and Daley G. Q. (2009) Cross-regulation of the Nanog and Cdx2 promoters. Cell Res, 19:1052-1061. 20. Chen L and Daley G. Q. (2008) Molecular basis of pluripotency. Hum Mol Genet, 17: R23-27.