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Ph.D. Univerity of Muenster, Germany M.Sc. University of Siegen, Germany B.Eng. Zhejiang University, China

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X-ray instrumentation Publications W. Shang, B. Robrahn, F. Golding and M. H. J. Koch, A versatile data acquisition system for time resolved X-ray scattering using gas proportional detectors with delay line readout, Nuc. Instr. Meth. A 530 (2004) 513-520. C. E. Blanchet, A. V. Zozulya, A. G. Kikhney, D. Franke, P. V. Konarev, W. Shang, R. Klaering, B. Robrahn, C. Hermes, F. Cipriani, D. I. Svergun and M. Roessle, Instrumental setup for high-throughput small- and wide-angle solution scattering at the X33 beamline of EMBL Hamburg, J. Appl. Cryst. (2012) 45 489-495 Small Angle X-ray Scattering Application on Biological Macromolecules Publications W. Shang, I. Ivanov, D. I. Svergun, O. Y. Borbulevych, A. M. Aleem, S. Stehling, J. Jankun, H. Kühn and E. Skrzypczak-Jankun, Probing dimerization and structural flexibility of mammalian lipoxygenases by small-angle X-ray scattering, J. Mol. Biol. (2011) 409, 654-668. I. Ivanov, W. Shang, L. Toledo, L. Masgrau, D. I. Svergun, S. Stehling, H. Gómez, A. Di Venere, G. Mei, J. M. Lluch, E. Skrzypczak-Jankun, à. González-Lafont and H. Kühn, Ligand induced formation of transient dimers of mammalian 12/15-Lipoxygenase: a key to allosteric behavior of this class of enzymes?, PROTEINS: Structure, Function, and Bioinformatics (2012), 80, 703-712. L. Brunotte, R. Kerber, W. Shang, F. Hauer, M. Hass, M. Gabriel, M. Lelke, C. Busch, H. Stark, D. I. Svergun, C. Betzel, M. Perbandt, S. Günther, Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy. J. Biol. Chem. (2011) 286, 38748-38756. F. Meersman, C. Atilgan, A. J. Miles, R. Bader, W. Shang, A. Matagne, B. A. Wallace and M. H. J. Koch, Consistent picture of the reversible thermal unfolding of Hen Egg-White Lysoyzme from experimental and molecular dynamics, Biophys. J. 99 (2010) 2255-2263. I. Lorenzen, W. Shang, M. Perbandt, M. V. Petoukhov, D. I. Svergun, G. H. Waetzig, S. Rose-John, R. Hilgenfeld and J. Gr?tzinger, The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution, Eur. J. Cell Biol. (2010) 90, 515-520. (contributed equally with first author). T. Zou, X. Yao, B. Qin, M. Zhang, L. Cai, W. Shang, D. I. Svergun, M. Wang, S. Cui and Q. Jin, Crystal structure of Pseudomonas aeruginosa Tsi2 Reveals a Stably Folded Superhelical Antitoxin, J. Mol. Biol. (2012) 417, 351-361. Y. Xiao, Q. Ma, T. Restle, W. Shang, D. I. Svergun, R. Ponnusamy, G. Sczakiel and R. Hilgenfeld, Nonstructural Proteins 7 and 8 of Feline Coronavirus Form a 2:1 Heterotrimer That Exhibits Primer-Independent RNA Polymerase Activity, J. Virol. 2012, 86:4444. E. de Almeida Ribeiro, M. Beich-Frandsen, P. V. Konarev, W. Shang, B. Vecerek, G. Kontaxis, H. Hammerle, H. Peterlik, D. I. Svergun, U. Blasi and K. Djinovic-Carugo, Structural flexibility of RNA as molecular basis for Hfq chaperone function, Nucleic Acids Research, 2012, vol. 40, 8072-8084. Z. Sayers, M. Aydin, E. Bal, F. Yesilirmak, P. V. Konarev, M. V. Petoukhov, M. Roessle, A. G. Kikhney, W. Shang and D. I. Svergun, Comparative Characteriztion of Apo-, Reconstituted- and In Vivo-Folded forms of a Durum Wheat Metallothionein, Biophysical Journal, 2013, vol. 104, 396A. A. Bowman, C. M. Hammond, A. Stirling, R. Ward, W. Shang, H. El-Mkami, D. A. Robinson, D. I. Svergun, D. G. Norman and T. Owen-Hughes, The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution, Nucleic Acids Research, 2014, vol. 42, 6038-6051.

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