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Biological/Physical

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Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design, with A. Ferguson et al., Immunity, 38, 606-617 (2013). “Coordinate linkage of HIV evolution reveals regions of immunological vulnerability”, with V Dahirel et al., Proc Natl. Acad. Sci, 108, 11530-11535 (2011). Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection, Nature (2010) Statistical mechanical concepts in immunology, Ann. Rev. Phys. Chem. (2010) Seeing in numbers, Scientist (2010) Pairing computational with experimentation: a powerful coupling for understanding T cell signaling, Nature Reviews Immunology (2010) Digital signaling and hysteresis characterize ras activation in lymphoid cells, Cell (2009) Efficient stochastic simulation of reaction-diffusion via direct compilation, Bioinformatics (2009) Thymic selection of T cell receptors as an extreme value problem, Phys Rev Lett (2009) How the thymus designs antigen-specific and self-tolerant T cell receptor sequences, PNAS (2008) “The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse”, with S. Cemarski et al., Immunity (2007). “CD4 Coordinates Lck Accumulation in the Immunological Synapse: Implications for the Sensitivity of T Cells to Antigen”, Nature Immunology (2004) “The Immunological Synapse Balances T Cell Receptor Signaling and Degradation”, Science (2003) Synaptic pattern formation during cellular recognition, PNAS (2001)

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