个人简介

B.S., Chemistry, B.S., Biology, Bates College Ph.D., Chemistry, University of California, Berkeley Postdoc, MRC Laboratory of Molecular Biology, Cambridge, UK

研究领域

Three-dimensional atomic structure and function of ribozymes, enzymes, and RNA-protein complexes, static and time-resolved X-ray crystallography, development of structure-based anti-viral agents, RNA evolution, origin of catalysis, and the origin of life.

I am trying to understand RNA structure, catalysis and the origin of life.

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

William G. Scott How fluorescent RNA gets its glow. Nature 513: 42-43 (2014). William G. Scott, Abraham Szöke, Josh Blaustein, Sara M. O'Rourke and Michael P. Robertson. RNA Catalysis, Thermodynamics and the Origin of Life. Life 4: 131-141 (2014). doi:10.3390/life4020131 Schultz, E. P., Vazquez, E., and Scott, W. G. Structural and catalytic effects of an invariant purine substitution in the hammerhead ribozyme: implications for the mechanism of acid - base catalysis. Acta Crystallographica Section D: Biological Crystallography D70: 2256-2263 (2014) Michael Anderson, Eric P. Schultz, Monika Martick and William G. Scott Active-Site Monovalent Cations Revealed in a 1.55 Å Resolution Hammerhead Ribozyme Structure Journal of Molecular Biology 425: 3790–3798 (2013). William G. Scott, Lucas H. Horan, and Monika Martick The Hammerhead Ribozyme: Structure, Catalysis,and Gene Regulation. Progress in Molecular Biology and Translational Science: Catalytic RNA, G. A. Soukup, ed. 120: 1-24 (2013). ISBN: 978-0-12-381286-5 Giambasu GM, Lee TS, Scott WG, York DM. Mapping L1 ligase ribozyme conformational switch. Journal of Molecular Biology 423:106-122 (2012) Scott WG. Challenges and surprises that arise with nucleic acids during model building and refinement. Acta Crystallogr D Biol Crystallogr. 68: 441-445 (2012) Adrian R. Ferré-D'Amaré and William G. Scott, Small Self-cleaving Ribozymes, RNA World, 4th ed., Cold Spring Harb Perspect Biol. 2010 Sep 15. [Epub ahead of print] William G. Scott, What can the New Hammerhead Ribozyme Structures Teach us About Design? V.A. Erdmann and J. Barciszewski (eds.), RNA Technologies and Their Applications, 305 RNA Technologies, DOI 10.1007/978-3-642-12168-5_14, # Springer-Verlag Berlin Heidelberg (2010) Robertson MP, Chi YI, Scott WG. Solving novel RNA structures using only secondary structural fragments. Methods. (2010) Jun 9. Emsley P, Lohkamp B, Scott WG, Cowtan K. Features and development of Coot. Acta Crystallogr D 66:486-501 (2010). Giambasu GM, Lee TS, Sosa CP, Robertson MP, Scott WG, York DM. Identification of dynamical hinge points of the L1 ligase molecular switch. RNA 16:769-80 (2010). William G. Scott, Monika Martick and Young-In Chi, Structure and function of regulatory RNA elements: Ribozymes that regulate gene expression Biochimica et Biophysica Acta 1789: 634-641 (2009). Sara M. O'Rourke, Becky Schweighardt, William G. Scott, Terri Wrin, Dora P. A. J. Fonseca, Faruk Sinangil, and Phillip W. Berman, Novel Ring Structure in the gp41 Trimer of Human Immunodeficiency Virus Type 1 That Modulates Sensitivity and Resistance to Broadly Neutralizing Antibodies. J. Virology 83: 7728-7738 (2009). Tai-Sung Lee, George M. Giambasu, Carlos P. Sosa, Monika Martick, William G. Scott and Darrin M. York, Threshold Occupancy and Specific Cation Binding Modes in the Hammerhead Ribozyme Active Site are Required for Active Conformation J. Mol. Biol. 388: 195-206 (2009). Andrei Korostelev, Haruichi Asahara, Laura Lancaster, Martin Laurberg, Alexander Hirschi, Jianyu Zhua, Sergei Trakhanova, William G. Scott, and Harry F. Noller, Crystal structure of a translation termination complex formed with release factor RF PNAS 105: 19684-19689 (2008). Jennifer Daub, Paul P. Gardner, John Tate, Daniel Ramsköld, Magnus Manske, William G. Scott, Zasha Weinberg, Sam Griffiths-Jones, and Alex Bateman, The RNA WikiProject: Community annotation of RNA families. RNA14: 1-3 (2008). Young-In Chi, Monika Martick, Rosalind Kim, William G. Scott and Sung-Hou Kim, Capturing Hammerhead Ribozyme Structures in Action by Modulating General Base Catalysis. PLoS Biology 6(9): e234. (2008). Monika Martick, Lucas H. Horan, Harry F. Noller and William G. Scott, A Discontinuous Hammerhead Ribozyme Embedded in a Mammalian mRNA. Nature 454: 899-902 (2008). Daniel J. Koslover, Anastasia J. Callaghan, Maria J. Marcaida, Elspeth F. Garman, Monika Martick, William G. Scott, and Ben F. Luisi, The Crystal Structure of the Escherichia coli RNase E Apoprotein and a Mechanism for RNA Degradation. Structure 16: 1238-1244 (2008).