吕林莉 - 东南大学

研究领域

主要研究方向为细胞外囊泡在肾脏炎症及纤维化中的作用机制及生物标志物研究。目前在研项目主要关注细胞外囊泡在肾小管上皮细胞损伤-修复中的作用及损伤信号的细胞间传递、细胞外囊泡作为治疗载体在肾脏病中的应用以及巨噬细胞模式识别受体Mincle在肾脏炎症调节中的作用。

近期论文

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1.Zuo-Lin Li#, Lin-Li Lv#, Tao-Tao Tang, Bin Wang, Ye Feng, Le-Ting Zhou,Jing-Yuan Cao, Ri-Ning Tang1, Min Wu1, Hong Liu, Steven D Crowley, Bi-ChengLiu. HIF-1a inducing exosomal microRNA-23a expression mediates the cross-talkbetween tubular epithelial cells and macrophages in tubulointerstitialinflammation. Kidney Int. 2018, in press. (Co-first author and co-correspondence)（IF=8.395） 2.Feng Ye#, Lv LL#, Wu WJ, LiZL, Li ZL, ChenJ, Ni HF, Tang TT, Liu BC.Urinary exosomes and exosomal CCL-2 mRNA as biomarkers of active histologicalinjury in IgA Nephropathy. Am J Pathol. 2018, Aug 22.pii: S0002-9440(18)30373-0.（IF=4.069）（Co-first author and co-correspondence） 3.LvLL, Feng Y, Wen Y, WuWJ, Ni HF, Li ZL, Zhou LT, Wang B, Zhang JD, CrowleySD, Liu BC. Exosomal CCL2 from tubular epithelial cells is critical for albumininduced tubulointerstitial inflammation. J Am Soc Nephrol. 2018 Mar;29(3):919-935.（IF= 8.966） 4.Lv LL, Wu WJ, Feng Y, Li ZL, Tang TT, Liu BC.Therapeutic application of extracellular vesicles in kidney disease: promisesand challenges. J Cell Mol Med. 2018 Feb;22(2):728-737. （IF =4.499） 5.Lv LL, Tang P, Li CJ, You YK, Li JH, HuangXR, Ni J, Feng M, Liu BC, Lan HY. The pattern recognition receptor, Mincle, is essentialfor maintaining the M1 macrophage phenotype in acute renal inflammation. Kidney Int. 2017Mar;91(3):587-602.（IF=8.395） 6.Lv LL, Liu BC. Role of non-classicalrenin-angiotensin system axis in renal fibrosis. FrontPhysiol. 2015 Apr 21;6:117. (IF=4.134) 7.Cao YH#, Lv LL#, Zhang X, Hu H, Ding LH,Yin D, Zhang YZ, Ni HF, Chen PS, Liu BC*.Urinary vimentin mRNA as a potentialnovel biomarker of renal fibrosis. Am JPhysiol Renal Physiol. 2015 Sep15;309(6):F514-22（Co-firstauthor）(IF=3.248) 8.Lv LL*, Cao Y, Liu D, Xu M, Liu H, Tang RN,Ma KL, Liu BC*. Isolation and Quantification of MicroRNAs from Urinary Exosomes/Microvesicles forBiomarker Discovery. Int J Biol Sci., 9(10):1021-31, 2013 (IF=4.509) （Correspondence） 9.LvLL, CaoYH, NiHF, Xu M, LiuD, LiuH, ChenPS, LiuBC*. microRNA 29c in urinary exosome/microvesicleas biomarker of renal fibrosis. Am J Physiol RenalPhysiol., 305(8):F1220-7, 2013 (IF=3.248)