刘必成 - 东南大学

研究领域

本研究组长期研究方向为肾脏炎症、纤维化的发生机制及血液透析并发症研究。目前研究主要聚焦细胞外囊泡在肾脏损伤中的作用及作为治疗载体的研究、肾小管上皮细胞损伤修复机制及透析心血管并发症研究。

近期论文

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1.Zhang Y, Ma KL, Gong YX, Wang GH, Hu ZB, Liu L, Lu J, ChenPP, Lu CC, Ruan XZ, Liu BC. PlateletMicroparticles Mediate Glomerular Endothelial Injury in Early DiabeticNephropathy. J Am Soc Nephrol. 2018 Nov;29(11):2671-2695. （IF= 8.966） 2.Liu BC, Tang TT, Lv LL, Lan HY. Renal tubuleinjury: a driving force toward chronic kidney disease. Kidney Int. 2018Mar;93(3):568-579. （IF=8.395） 3.Tang TT, Lv LL, Pan MM, Wen Y, Wang B, Li ZL, Wu M, WangFM, Crowley SD, Liu BC. Hydroxychloroquineattenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediatedNLRP3 inflammasome activation. Cell Death Dis. 2018 Mar2;9(3):351. (IF=5.965) 4.Zuo-Lin Li#, Lin-Li Lv#, Tao-Tao Tang, Bin Wang, Ye Feng,Le-Ting Zhou, Jing-Yuan Cao, Ri-Ning Tang1, Min Wu1, Hong Liu, Steven DCrowley, Bi-Cheng Liu. HIF-1a inducing exosomal microRNA-23a expressionmediates the cross-talk between tubular epithelial cells and macrophages intubulointerstitial inflammation. Kidney Int. 2018, in press. （IF=8.395） 5.Feng Ye#, Lv LL#, Wu WJ, Li ZL, Li ZL, Chen J, Ni HF, Tang TT, Liu BC. Urinary exosomes and exosomal CCL-2 mRNA as biomarkers of activehistological injury in IgA Nephropathy. Am J Pathol. 2018, Aug 22. pii:S0002-9440(18)30373-0.（IF=4.069） 6.Lv LL, Feng Y, Wen Y, Wu WJ, Ni HF, Li ZL, Zhou LT, Wang B, Zhang JD, Crowley SD, LiuBC. Exosomal CCL2 from tubular epithelial cells is critical for albumin inducedtubulointerstitial inflammation. J Am Soc Nephrol. 2018 Mar;29(3):919-935.（IF= 8.966） 7.Lv LL, Wu WJ, Feng Y, Li ZL, Tang TT, Liu BC. Therapeutic application of extracellular vesicles in kidneydisease: promises and challenges. J Cell Mol Med. 2018 Feb;22(2):728-737. （IF =4.499） 8.Lv LL, Tang P, Li CJ, You YK, Li JH, Huang XR, Ni J, FengM, Liu BC, Lan HY. The pattern recognition receptor, Mincle, is essential formaintaining the M1 macrophage phenotype in acute renal inflammation. Kidney Int. 2017Mar;91(3):587-602.（IF=8.395） 9.Zhu DD, Tang RN, Lv LL, Wen Y, Liu H, Zhang XL, MaKL, Liu BC. Interleukin-1βmediates high glucose induced phenotypic transition in human aortic endothelialcells. Cardiovasc Diabetol. 2016 Mar 5;15:42. (IF=5.235) 10.Lv LL, Liu BC. Role of non-classical renin-angiotensin system axis in renal fibrosis. Front Physiol. 2015Apr 21;6:117. (IF=4.134) 11.Liu D, Wen Y, Tang TT,Lv LL, Tang RN, Liu H, Ma KL, Crowley SD, Liu BC. Megalin/Cubulin-Lysosome-mediatedAlbumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3Inflammasome and Tubulointerstitial Inflammation. J Biol Chem. 2015 Jul17;290(29):18018-28. (IF=4.01) 12.Lv LL, Cao Y, Liu D,Xu M, Liu H, Tang RN, Ma KL, Liu BC. Isolation andQuantification of MicroRNAs fromUrinary Exosomes/Microvesicles for Biomarker Discovery. Int J Biol Sci.,9(10):1021-31, 2013 (IF=4.509)