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1978-1982 温州大学化学专业毕业 1985-1990 中国科学院上海药物所天然药物专业获硕士和博士学位 1991-1992 北京医科大学药学院博士后 1993-1996 北京医科大学药学院副教授 1996-现在 北京大学药学院教授 1993-1994 巴西Sao Paulo大学化学研究所和Rio de Janeiro大学访问学者 1995-1996 日本东邦大学药学部海外特别研究员 1999-2000 德国Wurzburg大学和Duesseldorf大学客座教授 2019-2022 北京大学海洋研究院副院长

研究领域

长期从事海洋生物天然产物结构与生物活性关系,海洋药物先导化合物发现等研究

近期论文

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Xueqing Chen, Longlong Si, Dong Liu, Peter Proksch, Lihe Zhang, Demin Zhou,* Wenhan Lin*. Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin. Eur. J. Med. Chem. 2015, 93, 182-195. Dong Liu, Hong Lin, Peter Proksch, Xixiang Tang, Zhongze Shao,, and Wenhan Lin* Microbacterins A and B, unusual peptaibols from the deep-sea actinomycete Microbacterium sediminis sp. nov. YLB-01(T). Org. Lett. 2015, 17 (5), 1220-1223. Yang Zhao, Longlong Si, Dong Liu, Peter Proksch, Demin Zhou, Wenhan Lin*. “Truncateols AN, new isoprenylated cyclohexanols from the sponge-associated fungus Truncatella angustata with anti-H1N1 virus activities”. Tetrahedron 2015, 71, 2708-2718 Siwen Niu,Dong Liu, Peter Proksch, Zongze Shao, Wenhan Lin* New polyphenols from a deep sea Spiromastix sp. fungus, and their antibacterial activities. Mar. Drugs 2015, 13(4), 2526-2540. Yi Yang, Yang Zhang, Dong Liu, Min Li-Weber, Bing Shao*, Wenhan Lin*. Dolabrane-type diterpenes from the mangrove plant Ceriops tagal with antitumor activities. Fitotherpia 2015, 103, 277-282. Jennifer Neumann, Yi Yang, Rebecca Köhler, Marco Giaisi, Mathias Witzens-Harig, Dong Liu, Peter H. Krammer, Wenhan Lin and Min Li-Weber “Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR–Chk1/Chk2-regulated cell cycle arrest”,Inter. J. Cancer 2015, 137, 2739–2748. Qi Wu,† Chongming Wu,‡ Hailin Long,† Ran Chen,‡ Dong Liu,† Peter Proksch,§ Peng Guo,‡,* Wenhan Lin*, “Varioxiranols A-G and 19-O-Methyl-22-methoxypre-shamixanthone, PKS and Hybrid PKS-Derived Metabolites from a Sponge Associated Emericella variecolor Fungus”, J. Nat. Prod. 2015, 10.1021/acs.jnatprod.5b00578. Yong Li, Chongming Wu, Dong Liu, Peter Proksch, Peng Guo, Wenhan Lin* “Chartarlactams A−P, phenylspirodrimanes from a sponge-associated fungus Stachybotrys chartarum with anti-hyperlipidemic activities” J. Nat. Prod. 2014, 77, 138-147. Siwen Niu, Dong Liu, Xinxin Hu, Peter Proksch, Zhongzhe Shao, Wenhan Lin “Spiromastixones A-O, antibacterial chlorodepsidones from a deep-sea derived Spiromastix sp. fungus” J. Nat. Prod. 2014, 77, 1021-1030. Yao Wang, Xixiang Tang, Zhongzhe Shao, Jinwei Ren, Dong Liu, Peter Proksch, Wenhan Lin* “Indole based alkaloids from deep-sea bacterium Shewanella piezotolerans with antitumor activities” J. Antibiotics 2014, 67, 395-399. Wei Cheng, Dong Liu, Fengying Zhang, Qingying Zhang, Patchara Pedpradab, Peter Proksch, Hong Liang, Wenhan Lin* “Formamidobisabolene-based derivatives from a sponge Axinyssa sp.” Tetrahedron, 2014, 70, 3576-3583. Dawei Chen, Wei Cheng, Dong Liu, Leen van Ofwegen, Peter Proksch, Wenhan Lin* . “Capillosananes SZ, new sesquiterpenoids from the soft coral Sinularia capillosa Tetra. Lett. 2014, 55, 3077-3082. Zehong Wu, Dong Liu, Peter Proksch, Peng Guo,Wenhan Lin* Punctaporonins H: caryophyllene-type sesquiterpenoids from the sponge-associated fungus Hansfordia sinuosae. Mar. Drugs 2014, 12(7), 3904-3916. Yong Li, Dong Liu, Shan Cen, Peter Proksch, and Wenhan Lin*. Isoindolinone-type alkaloids from the sponge derived fungus Stachybotrys chartarum”, Tetrahedron, 2014, 70, 7010-7015. Dong Liu, Aigang Yang, Chongming Wu, Peng Guo, Peter Proksch, Wenhan Lin*. Lipid lowering effects of farnesylquinone and related analogues from the marine-derived Streptomyces nitrosporeus. Bioorg. Med. Chem. Lett. 2014, 24, 5288-5293. Zhen Liu, Wei Cheng, Dong Liu, Leen van Ofwegen, Peter Proksch, Wenhan Lin*. Capnosane-type cembranoids from the soft coral Sarcophyton trocheliophorum with antibacterial effects. Tetrahedron 2014, 70, 8703-8713. Jian Bai, Dong Liu, Siwang Yu, Peter Proksch, Wenhan Lin*.Amicoumacins from the marinederived bacterium Bacillus sp. with the inhibition of NO production. Tetra. Lett. 2014. 55, 6286-6291. Jinwei Ren, Dong Liu, Li Tian, Yangye Wei, Peter Proksch, Jinzhang Zeng, Wenhan Lin *, “Venezuelines A–G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77” Bioorg. Med. Chem. Lett. 2013, 23, 301–304. Daowan Lai, Zhufeng Geng, Zhiwei Deng, Leen van Ofwegen, Peter Proksch, and Wenhan Lin*, “Cembranoids from the soft coral Sinularia rigida with antifouling activities” J. Agric. Food Chem. 2013, 61, 4585−4592. Jinwei Ren, Yi Yang, Dong Liu, Wei Chen, Peter Proksch, Bing Shao, Wenhan Lin* “Sequential determination of new peptaibols asperelines GZ12 produced by marine derived fungus Trichoderma asperellum using ultrahigh pressure liquid chromatography combined with electrosprayionization tandem mass spectrometry” J. Chromatogr. A, 2013, 1309, 90– 95. Zhifang Xi, Wei Bie, Wei Chen, Dong Liu, Leen van Ofwegen, Peter Proksch,Wenhan Lin * “ Sarcophyolides BE, New Cembranoids from the Soft Coral Sarcophyton elegans” Mar. Drugs 2013, 11, 3186-3196. Dawei Chen, Wei Chen, Dong Liu, Leen van Ofwegen, Peter Proksch, and Wenhan Lin*, “ AsteriscaneType Sesquiterpenoids from the Soft Coral Sinularia capillosa” J. Nat. Prod. 2013, 76, 1753−1763. Aigang Yang, Longlong Si, Zhenping Shi, Li Tian, Dong Liu, Demin Zhou, Peter Proksch, Wenhan Lin* “Nitrosporeusines A and B, unprecedented thioester-bearing alkaloids from the Arctic Streptomyces nitrosporeus” Org. Lett. 2013, 15, 5366-5369. Zhifang Xi, Wei Bie, Wei Chen, Dong Liu, Leen van Ofwegen, Peter Proksch and Wenhan Lin* “Sarcophytolides GL, New Biscembranoids from theSoft coral Sarcophyton elegans” Helv.Chim. Acta 2013, 96,2218-2227. Mona, E.N; Weaam, E.; Lin, W.H.; Gedara, S.; Badria, F.; Saad, H.E.A.; Lai, D.; Proksch, P. “Alkaloids and polyketides from Penicillium citrinum,an endophyte isolated from the Moroccan plant Ceratonia siliqua” J. Nat. Prod. 2013, online. Pham, C.; Weber, H.; Hartmann, R.; Wray, V.; Lin, W.H.; Lai, D.; Proksch, P. “New cytotoxic 1,2,4thiadiazole alkaloids from the ascidian Polycarpa aurata”Org. Lett. 2013, 15. 2230-2233. Wang, J.; Lin, W.H.; Wray, V.; Lai, D.; Proksch, P. “Induced production of depsipeptides by coculturing Fusarium tricinctum and Fusarium begonia” Tetrahedron Lett. 2013, 54, 2492-2496. Bara, R.; Zerfass, I.; Aly, A.H.; GoldbachGecke, H.; Raghavan, V.; Sass, P.; Mandi, A.; Wray, V.; Polavarapu, P.L.; Pretsch, A.; Lin, W.H.; Proksch, P.Atropisomeric dihydroanthracenones as inhibitors of multiresistant Staphylococcus aureus” J. Med. Chem. 2013, 56, 3257-3272. Ebrahim, W.; Aly, A.H.; Mandi, A.; Wray, V.; Essassi, El M.; Ouchbani, T.; Bouhfid, R.; Lin, W.H.; Proksch, P.; Kurtan, T. “OHeterocyclic embeurekols from embellisia eureka, an endophyte of Cladanthus arabicus” Chirality 2013, 25, 250-256. Ebrahim, W.; Aly, A.H.; Wray, V.r; Mandi, A.; Teiten, M.; Gaascht, F.; Orlikova, B.; Kassack, M.U.; Lin, W.H.; Diederich, M.; Proksch, P. “Embellicines A and B:absolute configuration and NF-κB transcriptional inhibitory activity” J. Med. Chem. 2013, 56, 2991-2999 Niemann, H.; Lin, W.H.; Mueller, W.E.G.; Kobbutat, M.; Lai, D.; Proksch, P. “Trimeric hemibastadin congener from the marine sponge Ianthella basta” J. Nat.Prod. 2013, 76, 121-125. Zhou, Y.; Debbab, A.; Mandi, A.; Wray, V.; Schulz, B.; Mueller, W.E.G.; Kassack, M.; Lin, W.H.; Kurtan, T.; Proksch, P.“Alkaloids from the sponge-associated fungus Aspergillus sp.” Eur. J. Org. Chem. 2013, 2013, 894-906. Yongxin Li, Shangjian Yu, Dong Liu, Peter Proksch, Wenhan Lin* “inhibitory effects of polyphenols toward HCV from the mangrove plant Excoecaria agallocha L.” Bioorg. Med. Chem. Lett. 2012, 22, 1099-1102. Jin Li, Huajie Zhu, Jinwei Ren, Zhiwei Deng, Nicole J. de Voogd, Peter Proksch, Wenhan Lin*, “Globostelletins JS, isomalabaricanes with unusual cyclopentane sidechains from the marine sponge Rhabdastrella globostellata”, Tetrahedron, 2012, 68, 559-565. Dawei Chen, Shanjiang Yu, Leen van Ofwegen, Peter Proksch, and Wenhan Lin*, “Anthogorgienes A−O, New Guaiazulene Derived Terpenoids from a 2 Chinese Gorgonian Anthogorgia Species, and Their Antifouling and Antibiotic Activities”, J. Agr. Food Chem. 2012, 60, 112-123. Haiyan Shi, Shanjiang Yu, Dong Liu, Leen van Ofwegen, Peter Proksch, Wenhan Lin*, “Sinularones AI, new cyclopentenone and butenolide derivatives from a marine soft coral Sinularia sp. and their antifouling activity”. Marine Drugs, 2012, 10, 1331-1344. Dawei, Chen; Dong, Liu, Shi, Shen; Wei Cheng; Wenhan Lin* “Terpenoids from a Chinese gorgonian Anthogorgia sp. and their antifouling activities” Chin. J. Chem. 2012, 30, 1459—1463. Shi Shen, Huajie Zhu, Dawei Chen, Dong Liu, Leen van Ofwegen, Peter Proksch, Wenhan Lin*, “ Pavidolides AE, new cembranoids from the soft coral Sinularia pavida, Tetrahedron Lett.” 2012, 53, 5759–5762. Daowan Lai, Dong Liu, Zhiwei Deng, Leen van Ofwegen, Peter Proksch, Wenhan Lin*, “Antifouling eunicellintype diterpenoids from the gorgonian Astrogorgia sp.” J. Nat. Prod. 2012. 75, 1595−1602. Lena Hammerschmidt, Victor Wray, WenHan Lin, Elena Kamilova, Peter Proksch, Amal H. Aly “New styrylpyrones from the fungal endophyte Penicillium glabrum isolated from Punica granatum” Phytochemistry Letters 2012, 6, 125-128. Yongxin Li, Ying Xu, Lingli Liu, Zhuang Han, Pok Yui Lai, Xiangrong Guo ,Xixiang Zhang, Wenhan Lin* PeiYuan Qian “Five new amicoumacins isolated from a marine-derived Bacterium Bacillus subtilis” Mar. Drugs 2012, 10, 319-328. Shi Shen, Dong Liu, Chen Wei, Peter Proksch, Wenhan Lin* “Purpuroines AJ, halogenated alkaloids from the sponge Iotrochota purpurea with antibiotic activity and regulation of tyrosine kinases”, Bioorg. Med. Chem. Lett. 2012, 20,6924–6928. Wei Jiang, Dong Liu, Zhiwei Deng, Nicole J. de Voogd, Peter Proksch, Wenhan Lin*, “Brominated polyunsaturated lipids and their stereochemistry from the Chinese marine sponge Xestospongia testudinaria” Tetrahedron 2011, 67, 58-68. Daowan Lai, Yongxin Li, Minjuan Xu, Zhiwei Deng, Leen van Ofwegen, Peiyuan Qian, Peter Proksch, Wenhan Lin* “Sinulariols AeS, 19oxygenated cembranoids from the Chinese soft coral Sinularia rigida” Tetrahedron 2011, 67, 6018-6029. Dong Liu, Jing Xu, Wei Jiang, Zhiwei Deng, Nicole J. de Voogd, Peter Proksch,Wenhan Lin* “Xestospongienols AL, brominated acetylenic acids from the Chinese marine sponge Xestospongia testudinaria” Helv. Chim. Acta 2011, 94, 1600-1607. Pengcheng Yan, Zhiwei Deng, Leen van Ofwegen, Peter Proksch, Wenhan Lin* “Lobophytones UZ1, biscembranoids from the Chinese soft coral Lobophytum pauciflorum”, Chem. Biodiver. 2011, 8, 1724-1734. Daowan Lai, Shanjiang Yu, Leen van Ofwegen, Frank Totzke, Peter Proksch, Wenhan Lin* “9,10Secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp.” Bioorg. Med. Chem. 2011, 19, 6873-6880. Xiu E. Feng, Wan Yi Zhao, Shu Rong Ban, Cheng Xiao Zhao, Qing Shan Li,Wen Han Lin* “StructureActivity Relationship of Halophenols as a New Class of Protein Tyrosine Kinase Inhibitors” Int. J. Mol. Sci. 2011, 12, 6104-6115. HongBing Liu, RuAngelie EdradaEbel, Rainer Ebel, Yao Wang, Barbara Schulz, Siegfried Draeger, Werner E. G. Muller, Victor Wray, WenHan Lin*, Peter Proksch* “Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus Aspergillus ustus.”. Helvetica Chimica Acta 2011, 94, 623-631. Sherif S. Ebada, Barbara Schulz, Victor Wray, Frank Totzke, Michael H. G. Kubbutat, Werner E. G. Müller, Alexandra Hamacher, Matthias U. Kassack, Wenhan Lin, Peter Proksch. “Arthrinins AD: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.” Bioorg. Med. Chem. 2011, 19, 4644–4651. Zhou, Yaming; Mandi, Attila; Debbab, Abdessamad; Wray, Victor; Schulz, Barbara; Mueller, Werner E. G.; Lin, Wenhan; Proksch, Peter; Kurtan, Tibor; Aly, Amal H. “New austalides from the sponge-associated fungus Aspergillus sp.” European J. Org. Chem. 2011, 6009-6019. Bayer, Mirko; Hellio, Claire; Marechal, JeanPhilippe; Frank, Walter; Lin, Wenhan; Proksch, Peter. „Antifouling bastadin congeners target mussel phenoloxidase and complex copper(II) ions.” Marine Biotechnology 2011, 13, 1148-1158. Ding, Ling; Maier, Armin; Fiebig, Heinz-Herbert; Lin, WenHan; Hertweck, Christian. “A family of multicyclic indolosesquiterpenes from a bacterial endophyte.” Org. Biomol. Chem. 2011, 9, 4029-4031. Ding, Ling; Maier, Armin; Fiebig, HeinzHerbert; Goerls, Helmar; Lin, WenHan; Peschel, Gundela; Hertweck, Christian. “Divergolides AD from a mangrove endophyte reveal an unparalleled plasticity in ansa-macrolide biosynthesis.” Angewandte Chemie, 2011, 50, 1630-1634 Cui Shi, Min-Juan Xu, Mirko Bayer, Zhi-Wei Deng, Michael H.G. Kubbutat, Wim Waejen,Peter Proksch, Wen-Han Lin, “Phenolic compounds and their anti-oxidative properties and protein kinase inhibition from the Chinese mangrove plant Laguncularia racemosa”, Phytochemistry 2010, 71, 435–442. Yan Pengcheng, Yang Lv, Leen van Ofwegen, Peter Proksch, Wenhan Lin* “lobophytones AG, new isobiscembranoids from the soft coral Lobophytum pauciflorum” Org. Lett. 2010, 12, 2484-2487. Jin Li, Bo Xu, Jinrong Cui, Zhiwei Deng, Nicole J. de Voogd, Peter Proksch, Wenhan Lin* Globostelletins AI, cytotoxic isomalabaricane derivatives from the marine sponge Rhabdastrella globostellata” Bioorg. Med. Chem. 2010, 18, 4639-4647. Guotao Fan, Zelin Li, Shi Shen, Yi Zeng, Yishu Yang, Minjuang Xu, Torsten Bruhn, Heike Bruhn, Joachim Morschhser, Gerhard Bringmann, Wenhan Lin „Baculiferins A–O, O-sulfated pyrrole alkaloids with anti-HIV1 activity, from the Chinese marine sponge Iotrochota baculifera”,Bioorg. Med. Chem. 2010,18, 5466–5474. Yongxin Li, Jun Liu, Shanjiang Yu, Peter Proksch, Jun Gu, Wenhan Lin*, “TNFa Inhibitory Diterpenoids from the Chinese Mangrove Plant Excoecaria agallocha L.” Phytochemistry, 2010, 71,2124-2131. Pengcheng Yan, Zhiwei Ddeng, Leen van Ofwegen, Peter proksch, Wenhan Lin*, “Lobophytones HN, Biscembranoids from the Chinese Soft Coral Lobophytum pauciflorum”,Chem. Pharm. Bull. 2010,58(12) 1591—1595. Pengcheng Yan, Zhiwei Deng, Leen van Ofwegen, Peter Proksch and Wenhan Lin* “Lobophytones O, new biscembranoids and cembranoid from soft coral Lobophytum pauciflorum. Mar. Drugs 2010, 8(11), 2837-2848. Abdessamad Debbab,1 Amal H. Aly,1 Wen H. Lin2 and Peter Proksch “Bioactive compounds from marine bacteria and fungi” Microbial Biotechnology 2010, 3,544–563. Ding, Ling; Muench, Jan; Goerls, Helmar; Maier, Armin; Fiebig, Heinz-Herbert; Lin, WenHan; Hertweck, Christian. “Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte”. Bioorg. Med. Chem. Lett. 2010, 20,

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