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个人简介

1992.09 - 1997.07 北京大学,化学与分子工程学院,化学,学士学位 1997.09 - 2002.07 中国科学院上海有机化学研究所,有机化学,博士学位, 2004.10 - 2009.07 美国俄亥俄州立大学,化学与生物化学系,博士后 2009.08 - 2015.11 中国科学院昆明植物研究所,研究员 2015.12 - 至今 云南大学自然资源药物化学教育部重点实验室,研究员

研究领域

1 、根据天然产物的生源合成途径和结构特征,研究金属、光照等条件下引发氧化产生单电子转移形成碳碳键的新方法学,采用仿生合成的策略,实现天然产物的高效率化学合成。 2、对已有的药物分子进行全新的合成路线研究,开发合成路线简洁、高收率和环保的化学合成工艺。

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Li, D.; Wu, T.; Liang, K.; Xia, C.* “Curtius-like Rearrangement of an Iron-Nitrenoid Complex and Application in Biomimetic Synthesis of Bisindolylmethanes” Organic Letters, 2016, 18, 2228−2231. Liang, K.; Wu, T.; Xia, C.* “Concise total synthesis of (±)-serotobenine” Organic & Biomolecular Chemistry 2016, 14, 4690-4696. Liang, K.; Yang, J.; Tong, X.; Shang, W.; Pan, Z.; Xia, C.* “Biomimetic Synthesis of Moschamine-Related Indole Alkaloids via Iron-Catalyzed Selectively Oxidative Radical Coupling” Organic Letters, 2016, 18, 1474−1477. Pan, Z.; Qin, X.-J.; Liu, Y.-P.; Wu, T.; Luo, X.-D.*; Xia, C.* “Alstoscholarisines H−J, Indole Alkaloids from Alstonia scholaris: Structural Evaluation and Bioinspired Synthesis of Alstoscholarisine H” Organic Letters, 2016, 18, 654-657. Ding, M.; Liang, K.; Pan, R.; Zhang, H.*; Xia, C.* “Total Synthesis of (+)-Chimonanthine, (+)-Folicanthine, and (−)-Calycanthine” The Journal of Organic Chemistry 2015, 80, 10309–10316. Ding, M.; Tong, X.; Li, D.; Liang, K.; Zhou, A.; Zuo, Z.; Xia, C.* “Asymmetric synthesis of common aza-tricyclic core of various alkaloids”Tetrahedron Letters 2015, 56, 5460-5464. Cui, Y.*; Li, Z.; Cheng, Z.; Xia, C.*; Zhang, Y.* “4,5-Cis Unsaturated ‑GalCer Analogues Distinctly Lead to CD1d-Mediated Th1-Biased NKT Cell Responses” Chemical Research in Toxicology 2015, 28, 1209-1215. Deng, X.; Liang, K.; Tong, X.; Ding, M.; Li, D.; Xia, C.* “Biomimetic synthesis of (-)-chaetominine epimers via copper-catalyzed radical cyclization” Tetrahedron 2015, 71, 3699-3704. Liang, K.; Deng, X.; Tong, X.; Li, D.; Ding, M.; Zhou, A.; Xia, C.* “Copper-Mediatd Dimerization to Access 3a,3a′-Bispyrrolidinoindoline: Diastereoselective Synthesis of (+)-WIN 64821 and (-)-Ditryptophenaline” Organic Letters 2015, 17, 206-209. Xu, J.; Shao, L. D.; Li, D.; Deng, X.; Liu, Y. C.; Zhao, Q. S.*; Xia, C.* “Construction of Tetracyclic 3‑Spirooxindole through Cross-Dehydrogenation of Pyridinium: Applications in Facile Synthesis of (±)-Corynoxine and (±)-Corynoxine B” Journal of the American Chemistry Society 2014, 136, 17962-17965. Deng, X.; Liang, K.; Tong, X.; Ding, M.; Li, D.; Xia, C.* “Copper-Catalyzed Radical Cyclization To Access 3‑Hydroxypyrroloindoline: Biomimetic Synthesis of Protubonine A” Organic Letters 2014, 16, 3276-3279. Ni, G.; Li, Z.; Liang, K.; Wu, T.; De Libero, G.; Xia, C.* “Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells” Bioorganic & Medicinal Chemistry 2014, 22, 2966-2973. Shao, L.-D.; Xu, J.; Gao, X.; He, J.; Zhao, Y.; Peng, L.-Y.; Luo, H.-R.; Xia, C.*; Zhao, Q.-S.* “Synthesis and neurite outgrowth promoting activity of vibsanin B derivatives” Tetrahedron Letters 2014, 55, 3414-3417. (IF = 2.379).

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