Gunjan, Akash - Florida State University - Department of Biomedical Sciences

个人简介

After finishing college in India, Dr. Gunjan moved to the United States to obtain his Ph.D. degree in biochemistry at the University of Mississippi Medical Center. He then moved to London, England, to carry out his post-doctoral research work at Cancer Research UK. Dr. Gunjan has around 20 years of experience in the field of chromatin structure and function and about 15 years of experience in the area of DNA damage and repair. He joined the faculty of the Department of Biomedical Sciences at the Florida State University College of Medicine as an Assistant Professor in March 2005. He was promoted to the rank of Associate Professor in August 2013.

近期论文

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Singh, R., Burkhart, S., Kabbaj, M-H., & Gunjan, A. (2013). The tumor suppressor CHK2 regulates histone protein levels in human cells. EMBO Reports. (Under revision) Gajjalaiahvari, U.R., Villeneuve, V., Kabbaj, M-H., Gharib, M., Thibault, P., Verreault, A., Gunjan, A., and Paik, J. (2013). Checkpoint kinases repress histone gene transcription in response to genotoxic agents that impede replication. PLoS Biology. (Under revision) Liang, D., Burkhart, S., Kabbaj, M-H., & Gunjan, A. (2012). Histone dosage regulates DNA damage sensitivity in a checkpoint independent manner via the homologous recombination pathway. Nucleic Acids Research, 40: 9604-9620. Singh, R., Gonzalez, M., Kabbaj, M-H., & Gunjan, A. (2012). Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae. PLOS One, 7: e36295. Hollis, F., Duclot, F., Gunjan, A., & Kabbaj, M. (2011). Individual differences in the effect of social defeat on anhedonia and histone acetylation in the rat hippocampus. Hormones & Behavior, 59: 331-7. Singh, R. K., & Gunjan, A. (2011). Histone tyrosine phosphorylation comes of age. Epigenetics, 6: 153-60. Hollis, F., Wang, H., Dietz, D., Gunjan, A., & Kabbaj, M. (2010). The effects of repeated social defeat on long-term depressive-like behavior and short-term histone modifications in the hippocampus in male Sprague-Dawley rats. Psychopharmacology (Berl), 211: 69-77. Gunjan, A., & Singh, R. K. (2010). Epigenetic therapy: targeting histones and their modifications in human disease. Future Medicinal Chemistry, 2: 543-8. Singh, R. K., Liang, D., Gajjalaiahvari, U. R., Kabbaj, M. H., Paik, J., & Gunjan, A. (2010). Excess histone levels mediate cytotoxicity via multiple mechanisms. Cell Cycle, 9: 4236-44. Morillo-Huesca. M., Mu?oz-Centeno, M.C., Singh, R.K., Reddy, G.U., Oreal, V., Liang, D., Maya, D., Gunjan, A., Géli, V., and Chávez, S. (2010). Accumulation of transcription-evicted histones induces a CLN3-dependent cell cycle delay in G1. PLOS Genetics, 6: e1000964. Singh, R.K., Kabbaj, M.M., Paik, J., and Gunjan, A. (2009). Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis. Nature Cell Biology, 11: 925-33. Singh, R.K., Paik, J., and Gunjan, A. (2009). Generation and management of excess histones during the cell cycle. Frontiers in Bioscience, 14: 3145-58. Gunjan, A., Paik J., and Verreault, A. (2006). The emergence of regulated histone proteolysis. Current Opinion in Genetics and Development. 16: 112-118. Gunjan, A., Paik, J. and Verreault, A. (2005). Regulation of histone synthesis and nucleosome assembly. Biochimie, 87: 625-635. Gunjan, A., and Verreault, A. (2003). A Rad53 kinase-dependent surveillance mechanism that regulates histone protein levels in Saccharomyces cerevisiae. Cell, 115: 537-549. Gunjan, A., and Brown, D. T. (2001). Modulation of core histone acetylation by linker histone stoichiometry in vivo. Journal of Biological Chemistry, 276(5): 3635-3640. Misteli, T., Gunjan, A., Hock, R., Bustin, M., and Brown, D. T. (2000). Dynamic binding of histone H1 to chromatin in living cells. Nature, 408: 877-881. Gunjan, A., and Brown, D. T. (1999). Overproduction of H1 histone variants in vivo increases basal and hormone-induced activity of the mouse mammary tumor virus promoter. Nucleic Acids Research, 27(16): 3355-3363. Gunjan, A., Alexander, B. T., Sittman, D. B., and Brown, D. T. (1999). Effects of H1 histone variant overexpression on chromatin structure. Journal of Biological Chemistry, 274(53): 37950-37956. Brown, D. T., Gunjan, A., Alexander, B. T., and Sittman, D. B. (1997). Differential effect of H1 variant overproduction on gene expression is due to differences in the central globular domain. Nucleic Acids Research, 25(24): 5003-5009.