个人简介
王海滨，男，1974年9月出生于浙江省义乌市，博士，研究员，博士生导师；中国科学院动物研究所胚胎着床生理学研究组组长。
“百人计划”引进海外杰出人才，国家杰出青年基金获得者，国家重大研究计划首席科学家。2000-2001年作为短期交换留学生在日本东京农工大农学部田谷一善先生研究室从事合作研究。2001年毕业于中国农业大学，获生理学理学博士学位。2001-2004年在美国堪萨斯大学医学中心和范德堡大学医学中心SKDey先生研究室进行博士后训练，曾获LalorFoundation博士后基金资助。2004-2007年在范德堡大学医学中心儿科系先后担任研究助理教授和助理教授。目前主要从事早期胚胎发育、着床和胎盘发生的分子机制研究，相关研究工作以第一作者或通讯作者分别发表在NatMed,JClinInvest,PLoSBiology,CellDeathDiffer,CellRes,PNAS、Development,JBC等杂志上，已发表SCI论文80多篇，2013年SCI论文他引率2000多次，并于2006年、2010年、2012年分别受邀为NatRevGenet,EndocrineRev,JClinInvest,MolAspectMed等杂志撰写特邀综述。王海滨博士多次受邀参加生殖生物学KeystoneSymposia并做大会报告，目前担任担任剑桥大学CTR的ScientificAdvisoryBoard,BiolReprod,PLoSONE等杂志编委会委员。获奖及荣誉：
Lalor博士后基金
Solvay/JosephMortola研究奖，由美国妇科研究学会（theSocietyforGynecologicInvestigation,SGI）颁发，2005年度唯一获奖人
“百人计划”引进国外人才（2008-2012年）
国家杰出青年基金获得者（2008年）
973首席科学家（2011年）
中国科学院青年科学家奖（2011年）
第十三届中国青年科技奖（2013年）
中国科学院“优秀百人”（2013年）
中国科学院朱李月华教师奖（2013年）
承担科研项目情况：
基金委重点项目-母-胎互作微环境决定妊娠结局的分子基础（81130009），2012-2016
基金委重点项目-胚胎着床的表观遗传调控机制（81330017），2014-2018
基金委重大项目-母-胎界面微环境训导母-胎免疫耐受的分子机制及其异常调控的致病机制（81490744），2015-2019
基金委面上项目-Notch信号通路在胚胎植入和蜕膜发育过程中的作用机制研究（31471106），2014-2018
国际学术会议主席和特邀大会报告：
Invitedspeaker,KeystoneSymposia(Reproduction:AdvancesandChallenges),SantaFe,NewMexico,USA,February20-25,2007.
Invitedspeaker,KeystoneSymposia(Reproduction:FrontiersinReproductiveBiologyandRegulationofFertility),SantaFe,NewMexico,USA,February1-6,2009.
Co-chair(EnkuiDuan,HaibinWang,SudhansuK.DeyandBruceMurphy),SKLRBSymposiaonFrontiersinPeriimplantationBiology,Beijing,ChinaMay8-12,2010.
NatureConference:TheHerrenhausenSymposiumonReproductiveBiology,Germany,,October4-7,2011.
Plenaryspeaker,the2ndWorldCongressonReproductiveBiology(WCRB),Cairns,Queensland,Australia,October9-12,2011.
Co-chair(EnkuiDuan,HaibinWang,SusanJ.FisherandSudhansuK.Dey),SKLRBSymposiaonFrontiersinReproductiveBiology,Beijing,China,May6-11,2012.
Invitedspeaker,The61stNIBBConference"CellularCommunityinMammalianEmbryogenesis",Okazaki,Japan,July10-12,2013.
Invitedspeaker，The47thJapaneseSocietyofDevelopmentalBiologists(JSDB),NagoyaJapan,May27–30,2014.
Invitedspeaker，2015CTRAnnualTrophoblastmeetingandtheCTR’sScientificAdvisoryBoard(SAB),July11-16,2015.
近期论文
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TuZ,WangQ,CuiT,WangJ,RanH,BaoH,LuJ,WangB,LydonJP,DeMayoF,ZhangS,KongS,WuXandWangH*.UterineRAC1viaPak1-ERMsignalingdirectsnormalluminalepithelialintegrityconducivetoon-timeembryoimplantationinmice.CellDeathDiffer.23(1):169-81，2016.
WuW,KongS,WangB,ChenY,WangH*.Spatiotemporalexpressionofendogenousopioidprocessingenzymesinmouseuterusatperiimplantation.CellTissueRes.363(2):555-65，2016.
JiangY,LiaoY,HeH,XinQ,TuZ,KongS,CuiT,WangB,QuanS,LiB,ZhangS,WangH*.FoxM1DirectsSTAT3ExpressionEssentialforHumanEndometrialStromalDecidualization.SciRep.5:13735,2015.
HuX,TangZ,LiY,LiuW,ZhangS,WangB,TianY,ZhaoY,RanH,LiuW,FengGS,ShuaiJ,WangH*,LuZ.DeletionofthetyrosinephosphataseShp2inSertolicellscausesinfertilityinmice.SciRep.5:12982,2015
HeH,KongS,LiuF,ZhangS,JiangY,LiaoY,JiangY,LiQ,WangB,ZhouZ,WangH*,HuoR.Rbbp7IsRequiredforUterineStromalDecidualizationinMice.BiolReprod.93(1)13,1-11,2015.
LiaoY,JiangY,HeH,NiH,TuZ,ZhangS,WangB,LouJ,QuanS,WangH*.NEDD8-mediatedneddylationisrequiredforhumanendometrialstromalproliferationanddecidualization.HumReprod.30(7):1665-76,2015.
TangX,ChenY,RanH,JiangY,HeB,WangB,KongS,WangH*.Systemicmorphinetreatmentderailsnormaluterinereceptivity,leadingtoembryoimplantationfailureinmice.BiolReprod.92(5):0,1-9,2015.
ChenY,KongS,TangX,FuY,WangB,ZhangS,WangH*.Preimplantationmouseembryoisatargetforopioidligand-receptorsignaling.BiolReprod.91(1):4,1–9,2014.
TuZ,RanH,ZhangS,XiaG,WangB,WangH*.MolecularDeterminantsofUterineReceptivity.Int.J.Dev.Biol.58:147-154,2014.
FuZ,WangB,WangS,WuW,WangQ,JinW,DuanE,WangH,WangY,Li,L，WangF,GaoS,WangH*.IntegralProteomicAnalysisofBlastocystsRevealsKeyMolecularMachineryGoverningEmbryonicDiapauseandReactivationforImplantation.BiolReprod.90(3):52,1–11,2014.
ZhangS,KongS,WangB,ChengX,ChenY,WuW,WangQ，ShiJ,ZhangY,WangS,LuJ,JohnPLydon,FrancescoDeMayo,WarrenS.Pear,HuaH,LinH,LiL,WangH,WangY,LiB,ChenQ,DuanE,WangH*.UterineRbpjisrequiredforembryo-uterineorientationanddecidualremodelingviaNotchpathway-independentand-dependentmechanisms.CellRes.24(8):925-942,2014.
WangQ,LuJ,ZhangS,WangS,WangW,WangB,WangF,ChenQ,DuanE,LeitgesM,KispertA,WangH*.Wnt6isessentialforstromalcellproliferationduringdecidualizationinmice.BiolReprod.88(1):1-9,2013.
FuZ,ChenY,WuW,WangS,WangW,WangB,WangH*.Molecularandcellularaspectsofblastocystdormancyandreactivationforimplantation.JStemCells.2013;8(2):59-77.
LuJ,ZhangS,NakanoN,SimmonsDG,WangS,WangQ,KongS,ShenL,WangW,WangB,WangHM,WangYL,vanEsJH,CleversH,LeoneG,CrossJC,WangH*.ApositivefeedbackloopinvolvingGcm1andFzd5directschorionicbranchingmorphogenesisintheplacenta.PLoSBiology.11(4),e1001536,2013.
ZhangS,LinH,KongS,WangS,WangH,WangH*,ArmantDR*(Co-correspondence)..Physiologicalandmoleculardeterminantsofembryoimplantation.MolAspectsMed.34,939-980,2013.
WangQ,LuJ,ZhangS,WangS,WangW,WangB,WangF,ChenQ,DuanE,LeitgesM,KispertA,WangH*.Wnt6isessentialforstromalcellproliferationduringdecidualizationinmice.BiolReprod.88(1):5,2013
ZhangS,KongS,LuJ,WangQ,ChenY,WangW,WangB,WangH*.Decipheringthemolecularbasisofuterinereceptivity.MolReprodDev.80(1):8-21,2013
KongS,ZhangS,ChenY,WangW,WangB,ChenQ,DuanE*,WangH*.Determinantsofuterineaging:lessonsfromrodentmodels.SciChinaLifeSci.55(8):687-93,2012
LimH&WangH*(Co-correspondence).Uterinedisordersandpregnancycomplications:insightsfrommousemodels.JCIinInvest.120(4),1004-15,2010
ChenQ,ZhangY,LuJ,WangQ,WangS,CaoY,WangH*,DuanE*(Co-correspondence).Embryo-uterinecross-talkduringimplantation:TheroleofWntsignaling.MolHumReprod.15(4):215-21,2009
XieH,TranguchS,JiaX,ZhangH,DasSK,DeySK,KuoCJ,andWangH*(*Correspondence).InactivationofNuclearWnt-β-CateninSignalingLimitsBlastocystCompetencyforImplantation.Development.135(4):717-727,2008
XieH*,WangH*(equalcontribution),TranguchS,IwamotoR,MekadaE,DeMayoFJ,LydonJP,DasSKandDeySK.Heparin-bindingEGF-likegrowthfactorservesasamolecularlinkbetweentheblastocystanduterusduringimplantation.PNAS.104(46):18315-20,2007
WangH*,XieH*(equalcontribution),SunX,TranguchS,ZhangH,JiaX,WangD,DasSK,DesvergneB,WahliW,DuBoisRNandDeySK.Stage-specificintegrationofmaternalandembryonicPPARδsignalingiscriticaltopregnancysuccess.JBiolChem.282(52):37770-37782,2007
WangH*,XieH,GuoY,ZhangH,TakahashiT,KingsleyPJ,MarnettLJ,DasSK,CravattBFandDeySK.Fattyacidamidehydrolasedeficiencylimitsearlypregnancyevents.JCIinInvest.116(8):2122-2131,2006
WangH*,DeySKandMaccarroneM.JekyllandHyde:Twofacesofcannabinoidsignalinginmaleandfemalefertility.EndocrRev.27(5):427-448,2006
WangH*andDeySK.Roadmaptoembryoimplantation:Cluesfrommousemodels.NatRevGenet.7(3):185-199,2006
WangH*,TranguchS*(equalauthor),XieH,HanleyG,DasSK,DeySK.Variationincommercialrodentdietsinducesdisparatemolecularandphysiologicalchangesinthemouseuterus.PNAS.102(28):9960-9965,2005
GuoY*,WangH*(equalauthor),OkamotoY,UedaN,KingsleyPJ,MarnettLJ,SchmidHH,DasSK,DeySK.N-acylphosphatidylethanolamine-hydrolyzingphospholipaseDisanimportantdeterminantofuterineanandamidelevelsduringimplantation.JBiolChem.280(25):23429-23432,2004
WangH*,MaW,TejadaL,ZhangH,MorrowJD,DasSK,andDeySK.RescueoffemaleinfertilityfromthelossofCyclooxygenase-2bycompensatoryupregulationofCyclooxygenase-1isafunctionofgeneticmake-up.JBiolChem.279(11):10649-10658,2004
WangH*,GuoY,WangD,KingsleyPJ,MarnettLJ,DasSK,DuBoisRNandDeySK.Aberrantcannabinoidsignalingimpairsoviductaltransportofembryos.NatMed.10(10):1074-1080,2004
WangH*,MatsumotoH,GuoY,PariaBC,RobertsRL,andDeySK.DifferentialG-Proteincoupledcannabinoidreceptorsignalingbyanandamidedirectsblastocystactivationforimplantation.PNAS.100(25):14914-14919,2003
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