Tschudi, Christian - Yale University - Biological & Biomedical Sciences

个人简介

Christian Tschudi is Professor of Epidemiology and Director of Graduate Studies at the Yale School of Public Health. He also directs an NIH-sponsored pre-doctoral and post-doctoral training program in Parasitology and Vector Biology. The goal of the program is to provide trainees with both a strong intellectual foundation through coursework and rigorous experimental training in areas that take molecular, cellular, immunological, epidemiological and ecological approaches to the study of pathogens and their vectors. Dr. Tschudi earned an A.B. in microbiology and a Ph.D. in biochemistry from the University of Basel in Switzerland. Dr. Tschudi is an expert on neglected tropical diseases, as evidenced by editorial board and study section appointments and a Burroughs Wellcome Award. He is currently a permanent member of the NIH study section on pathogenic eukaryotes and the organizer of the international conference on kinetoplastid molecular cell biology. Dr. Tschudi’s studies focus on the biology of trypanosomes the causative agents of devastating diseases in Africa and South America with special emphasis on gene expression profiling using next-generation sequencing technologies. PhD University of Basel (1982)

研究领域

Parasitic Diseases; Tropical Medicine; Trypanosomiasis, African; Genomics; RNA Interference

近期论文

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Developmental progression to infectivity in Trypanosoma brucei triggered by an RNA-binding protein. Kolev, N.G., Ramey-Butler, K., Cross, G.A., Ullu, E., and Tschudi, C. (2012) Developmental progression to infectivity in Trypanosoma brucei triggered by an RNA-binding protein. Science 338(6112):1352-1353. Comparative genomics reveals two novel RNAi factors in Trypanosoma brucei and provides insight into the core machinery Barnes, R.L., Shi, H., Kolev, N.G., Tschudi, C. and Ullu E. (2012) Comparative genomics reveals two novel RNAi factors in Trypanosoma brucei and provides insight into the core machinery PLoS Pathog 8(5): e1002678. doi:10.1371/journal.ppat.1002678. The transcriptome of the human pathogen Trypanosoma brucei at single-nucleotide resolution. Kolev, N.G., Franklin, J.B., Carmi, S., Shi, H., Michaeli, S. and Tschudi, C. (2010). The transcriptome of the human pathogen Trypanosoma brucei at single-nucleotide resolution. PLoS Pathog., 6(9): e1001090. doi:10.1371/journal.ppat.1001090. Retention and loss of RNA interference pathways in trypanosomatid protozoans. Lye, L.F., Owens, K., Shi, H., Murta, S.M., Vieira, A.C., Turco, S.J., Tschudi, C., Ullu, E. and Beverley, S.M. (2010). Retention and loss of RNA interference pathways in trypanosomatid protozoans. PLoS Pathog., 6(10): e1001161. doi:10.1371/journal.ppat.1001161. Distinct and overlapping roles for two Dicer-like proteins in the RNA interference pathways of the ancient eukaryote Trypanosoma brucei. Patrick, K.L, Shi, H., Kolev, N.G., Ersfeld, K., Tschudi, C. and Ullu, E. (2009). Distinct and overlapping roles for two Dicer-like proteins in the RNA interference pathways of the ancient eukaryote Trypanosoma brucei. Proc. Natl. Acad. Sci. U S A, 106, 17933-17938. A protein related the vaccinia virus cap-specific methyltransferase VP39 is involved in cap 4 modification in Trypanosoma brucei. Arhin, G.K., Li, H., Ullu, E., and Tschudi, C. (2006). A protein related the vaccinia virus cap-specific methyltransferase VP39 is involved in cap 4 modification in Trypanosoma brucei. RNA 12:53-62. Chikne V, Gupta SK, Doniger T, K SR, Cohen-Chalamish S, Ben-Asher HW, Kolet L, Yahia NH, Unger R, Ullu E, Kolev NG, Tschudi C, Michaeli S: The Canonical Poly (A) Polymerase PAP1 Polyadenylates Non-Coding RNAs and Is Essential for snoRNA Biogenesis in Trypanosoma brucei. J Mol Biol. 2017 Apr 26; 2017 Apr 26. PMID: 28456523 Savage AF, Kolev NG, Franklin JB, Vigneron A, Aksoy S, Tschudi C: Transcriptome Profiling of Trypanosoma brucei Development in the Tsetse Fly Vector Glossina morsitans. PLoS One. 2016; 2016 Dec 21. PMID: 28002435 Chikne V, Doniger T, Rajan KS, Bartok O, Eliaz D, Cohen-Chalamish S, Tschudi C, Unger R, Hashem Y, Kadener S, Michaeli S: A pseudouridylation switch in rRNA is implicated in ribosome function during the life cycle of Trypanosoma brucei. Sci Rep. 2016 May 4; 2016 May 4. PMID: 27142987 Ramey-Butler K, Ullu E, Kolev NG, Tschudi C: Synchronous expression of individual metacyclic variant surface glycoprotein genes in Trypanosoma brucei. Mol Biochem Parasitol. 2015 Mar-Apr; 2015 Apr 18. PMID: 25896436 Kolev NG, Ullu E, Tschudi C: Construction of Trypanosoma brucei Illumina RNA-Seq libraries enriched for transcript ends. Methods Mol Biol. 2015. PMID: 25388113 Eliaz D, Doniger T, Tkacz ID, Biswas VK, Gupta SK, Kolev NG, Unger R, Ullu E, Tschudi C, Michaeli S: Genome-wide analysis of small nucleolar RNAs of Leishmania major reveals a rich repertoire of RNAs involved in modification and processing of rRNA. RNA Biol. 2015; 2015 May 13. PMID: 25970223 Kolev NG, Ullu E, Tschudi C: The emerging role of RNA-binding proteins in the life cycle of Trypanosoma brucei. Cell Microbiol. 2014 Apr; 2014 Feb 16. PMID: 24438230 Ericson M, Janes MA, Butter F, Mann M, Ullu E, Tschudi C: On the extent and role of the small proteome in the parasitic eukaryote Trypanosoma brucei. BMC Biol. 2014 Feb 19; 2014 Feb 19. PMID: 24552149 Shi H, Barnes RL, Carriero N, Atayde VD, Tschudi C, Ullu E: Role of the Trypanosoma brucei HEN1 family methyltransferase in small interfering RNA modification. Eukaryot Cell. 2014 Jan; 2013 Nov 1. PMID: 24186950 Atayde VD, Shi H, Franklin JB, Carriero N, Notton T, Lye LF, Owens K, Beverley SM, Tschudi C, Ullu E: The structure and repertoire of small interfering RNAs in Leishmania (Viannia) braziliensis reveal diversification in the trypanosomatid RNAi pathway. Mol Microbiol. 2013 Feb; 2012 Dec 26. PMID: 23217017 Kolev NG, Ramey-Butler K, Cross GA, Ullu E, Tschudi C: Developmental progression to infectivity in Trypanosoma brucei triggered by an RNA-binding protein. Science. 2012 Dec 7. PMID: 23224556 Tschudi C, Shi H, Franklin JB, Ullu E: Small interfering RNA-producing loci in the ancient parasitic eukaryote Trypanosoma brucei. BMC Genomics. 2012 Aug 27; 2012 Aug 27. PMID: 22925482 Barnes RL, Shi H, Kolev NG, Tschudi C, Ullu E: Comparative genomics reveals two novel RNAi factors in Trypanosoma brucei and provides insight into the core machinery. PLoS Pathog. 2012; 2012 May 24. PMID: 22654659