McMahon-Pratt, Diane - Yale University - Biological & Biomedical Sciences

个人简介

The research in Professor McMahon-Pratt's laboratory is concerned with the parasitic protozoan, Leishmania, which causes a spectrum of diseases known as leishmaniasis. The laboratory is interested in understanding the immune effector mechanisms in the mammalian host that are involved in the control of infection and/or pathogenesis, with the aim to developing a vaccine against leishmaniasis. The laboratory has defined target vaccine candidate molecules and is collaborating with the University of Iowa and Cambridge University in a project directed toward the development of a multi-subunit vaccine. In addition, we are collaborating with Dr. Tarek Fahmy (L Yale Bioengineering) in the development of nanoparticle therapeutic treatment delivery system for leishmaniasis. In other studies, the laboratory also collaborates Drs. Al Bothwell and Eddie Chae (Immunobiology) investigating the role of DKK-1 in the regulation of the innate and T cell responses to Leishmania infection. We have long-term collaboration with scientists in Colombia. Currently, Professor McMahon-Pratt is director of NIAID R01 and Fogarty (NIH)-sponsored Programs with Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM) in Colombia. These program are focused on understanding the pathology of leishmaniasis caused by Leishmania (Viannia), which predominates in South America, with the objective of designing immunological approaches for treatment and control. PhD Harvard University (1978) BS University of Southern California (1969) Post-Doctoral Fellow Harvard Medical School

研究领域

Biochemistry; Epidemiology; Leishmaniasis; Microbiology; Parasitology; Tropical Medicine

近期论文

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CD4 T cell activation by B cells in human Leishmania (Viannia) infection Rodriguez-Pinto, D., Saravia, N.G. and McMahon-Pratt, D. 2014. B cells are competent antigen presenting cells in Leishmania (Viannia) infection. BMC Infect Dis. Feb 25;14:108. doi: 10.1186/1471-2334-14-108. Chronicity of cutaneous leishmaniasis caused by Leishmania panamensis is associated with parasite mediated induction of chemokine gene expression. Navas , A., Vargas , D. A., Freudzon, M., McMahon-Pratt, D., Saravia, N.G. and Gómez, M.A. 2014. Chronicity of cutaneous leishmaniasis caused by Leishmania panamensis is associated with parasite mediated induction of chemokine gene expression. Infect. Immun., 82:2872-80. The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection. Ehrlich,A.K., Castilho,T., Goldsmith-Pestana, K. Chae, W.-J., Bothwell, A., Sparwasser, T. and McMahon-Pratt, D. 2014.The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection. J. Immunol. 193:2961-70. The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection. Dawn M. Wetzel, D.M., McMahon-Pratt, D.M. and Koleske, A.J. 2012.The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection. Mol Cell Biol. 2012 Aug;32(15):3176-86. Human macrophage response to L. (Viannia) panamensis: microarray evidence for an early inflammatory response. Ramírez, C. Díaz,Y,. Tellez, J., Castilho, TM, Rojas, R., Ettinger, NA, Tikhonova, I., Alexander,NA, Hager, J., Wilson, ME, Lin, A., Zhao, H., Saravia, NG, and McMahon- Pratt, . 2012. Human Macrophage Response to L. (Viannia) panamensis Infection: The TLR1/2 agonist Pam3CSK4 enhances specific CD8+ responses in heterologous prime-boost vaccination and provides protection against chronic Leishmania Viannia) panamensis infection Jayakumar, A., Park, E., Castilho, T., Goldsmith-Pestana, K., Blackwell, J. and McMahon-Pratt, D. 2010. (. PLoS Negl Trop Dis. 2011 Jun;5(6):e1204. doi: 10.1371/journal.pntd.0001204. Murine model of chronic L. (Viannia) panamensis infection: role of IL-13 in disease. Castilho, T., Goldsmith-Pestana, K., Lozano, C., Valderrama, L., Saravia, N.G. and McMahon Pratt, D. 2010. Murine Model of Chronic L. (Viannia) panamensis Infection: Role of IL-13 in Disease. Eur. J. Immunol., 40(10):2816-29. Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease? McMahon-Pratt, D. and Alexander, J. (2004). Does the Leishmania major paradigm of pathogenesis and protection hold for New World Cutaneous Leishmaniases or the visceral disease? Immunological Rev. 201:206-224. Heterogeneity, geographic distribution, and pathogenicity of serodemes of Leishmania viannia in Colombia. Saravia, N.G., Weigle, K., Navas, C., Segura, I., Valderrama, L., Valencia, A.Z., Escorcia, B., and McMahon-Pratt, D. Heterogeneity, Geographic Distribution, and Pathogenicity of Serodemes of Leishmania (Viannia) in Colombia. American Journal of Tropical Medicine Hygiene 66: 738-744, 2002. A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses. Kamir D, Zierow S, Leng L, Cho Y, Diaz Y, Griffith J, McDonald C, Merk M, Mitchell RA, Trent J, Chen Y, Kwong YK, Xiong H, Vermeire J, Cappello M, McMahon-Pratt D, Walker J, Bernhagen J, Lolis E, Bucala R. A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses. J Immunol. 2008 Jun 15;180(12):8250-61. Murine visceral leishmaniasis: IgM and polyclonal B-Cell activation lead to disease exacerbation Deak E, Jayakumar A, Cho KW, Goldsmith-Pestana K, Dondji B, Lambris JD, and McMahon-Pratt D.2010. Murine visceral leishmaniasis: IgM and polyclonal B-Cell activation lead to disease exacerbation. Eur J Immunol. Eur. J. Immunol. 40: 1355-68. Dickkopf-1 is a molecular switch for chronic inflammation to environmental pathogens. Chae, W-J., Ehrlich, A.K., Chan, P.Y., Henegariu, O., Hao, L. Goldsmith-Pestana, K., Tang, W.H., Teixeira, A.M., Kim, S.-T., Park, J.-H., Maher, S., Hwa, J., Rothlin, C.V., McMahon-Pratt, D. and Bothwell, A.L.M. 2016. Immunity 44(2):246-58. A Leishmania-encoded cytokine influences host innate and adaptive immunity to promote parasite persistence. Holowka, T., Castilho, T.M., Baeza Garcia, A., Sun, T., McMahon-Pratt, D., Bucala, R. 2016. parasite persistence. FASEB J. 2016 Mar 8. pii: fj.201500189R Immunomodulatory nanoparticles ameliorate disease in the Leishmania (Viannia) panamensis mouse model.