个人简介
The Kupfer laboratory is working on HTLV I Tax protein, which has a unique kinase activation activity. They are harnessing this activity in order to chemosensitize p53 mutant tumor cells, thereby serving as an adjunct to enhance cancer therapy.
MD Johns Hopkins University School of Medicine (1989)
BS University of Florida (1983)
Post-doctoral Fellow Dana-Farber Cancer Institute, Boston, MA
Fellow Children's Hospital, Boston, MA
Resident Children's Hospital of Philadelphia, Philadelphia, PA
Research Associate John Hopkins School of Medicine Baltimore, MD
Board Certification AB of Pediatrics, Pediatric Hematology-Oncology (1996, recertified: 2011)
研究领域
Fanconi Anemia; Hematology; Medical Oncology; Neoplasms by Histologic Type; Pediatrics; Therapeutics; Genomic Instability
近期论文
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The Fanconi anemia core complex associates with chromatin during S phase.
Mi J, Kupfer GM. (2005). The Fanconi anemia core complex associates with chromatin during S phase. Blood 105(2):759-66.
Human T Cell Leukemia Virus I Tax1 Protein Sensitizes p53 Mutant Cells to DNA Damage.
Mihaylova V, Green A, Khurgel M, Semmes OJ, Kupfer GM. (2008) Human T Cell Leukemia Virus I Tax1 Protein Sensitizes p53 Mutant Cells to DNA Damage. Cancer Research, in press.
Liang F, Longerich S, Miller AS, Tang C, Buzovetsky O, Xiong Y, Maranon DG, Wiese C, Kupfer GM, Sung P: Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex. Cell Rep. 2016 Jun 7; 2016 May 26. PMID: 27239033
Faustino EV, Li S, Silva CT, Pinto MG, Qin L, Tala JA, Rinder HM, Kupfer GM, Shapiro ED, Northeast Pediatric Critical Care Research Consortium.: Factor VIII May Predict Catheter-Related Thrombosis in Critically Ill Children: A Preliminary Study. Pediatr Crit Care Med. 2015 Jul. PMID: 25828784
Longerich S, Li J, Xiong Y, Sung P, Kupfer GM: Stress and DNA repair biology of the Fanconi anemia pathway. Blood. 2014 Oct 30; 2014 Sep 18. PMID: 25237197
Chen X, Wilson JB, McChesney P, Williams SA, Kwon Y, Longerich S, Marriott AS, Sung P, Jones NJ, Kupfer GM: The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other's chromatin localization. J Biol Chem. 2014 Sep 12; 2014 Jul 28. PMID: 25070891
Longerich S, Kwon Y, Tsai MS, Hlaing AS, Kupfer GM, Sung P: Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA. Nucleic Acids Res. 2014 May; 2014 Mar 12. PMID: 24623813
Kupfer GM: Fanconi anemia: a signal transduction and DNA repair pathway. Yale J Biol Med. 2013 Dec 13; 2013 Dec 13. PMID: 24348213
Chirnomas SD, Kupfer GM: The inherited bone marrow failure syndromes. Pediatr Clin North Am. 2013 Dec. PMID: 24237972
Omer B, Kadan-Lottick NS, Roberts KB, Wang R, Demsky C, Kupfer GM, Cooper D, Seropian S, Ma X: Patterns of subsequent malignancies after Hodgkin lymphoma in children and adults. Br J Haematol. 2012 Sep; 2012 Jul 6. PMID: 22775513
Lo SM, Choi M, Liu J, Jain D, Boot RG, Kallemeijn WW, Aerts JM, Pashankar F, Kupfer GM, Mane S, Lifton RP, Mistry PK: Phenotype diversity in type 1 Gaucher disease: discovering the genetic basis of Gaucher disease/hematologic malignancy phenotype by individual genome analysis. Blood. 2012 May 17; 2012 Apr 4. PMID: 22493294
Williams SA, Wilson JB, Clark AP, Mitson-Salazar A, Tomashevski A, Ananth S, Glazer PM, Semmes OJ, Bale AE, Jones NJ, Kupfer GM: Functional and physical interaction between the mismatch repair and FA-BRCA pathways. Hum Mol Genet. 2011 Nov 15; 2011 Aug 24. PMID: 21865299
Williams SA, Longerich S, Sung P, Vaziri C, Kupfer GM: The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI. Blood. 2011 May 12; 2011 Feb 25. PMID: 21355096
Halene S, Gao Y, Hahn K, Massaro S, Italiano JE Jr, Schulz V, Lin S, Kupfer GM, Krause DS: Serum response factor is an essential transcription factor in megakaryocytic maturation. Blood. 2010 Sep 16; 2010 Jun 4. PMID: 20525922
Green AM, Kupfer GM: Fanconi anemia. Hematol Oncol Clin North Am. 2009 Apr. PMID: 19327579
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