柯琼 - 中山大学 - 中山医学院

个人简介

现任广东省医学会细胞治疗学分会青年委员会委员，广东省中医药学会整合生殖医学专业委员会委员，干细胞与组织工程教育部重点实验室研究人员，广东省生殖医学重点实验室研究人员。

研究领域

主要研究成果包括：利用基因编辑技术建立多种人类遗传疾病灵长类动物模型，包括MCPH1基因缺失小脑症食蟹猴模型、FAH基因缺失酪氨酸血症I型食蟹猴模型及SHANK3基因缺失自闭症食蟹猴模型等，首次证实利用TALEN技术可以获得具有显著表型的食蟹猴模型；建立了多种转基因小鼠及人类的正常和疾病多能干细胞系；首次证实CX43能促进细胞重编程效率，为提高iPSC的形成效率及探讨细胞重编程机制提供重要的理论基础等。

近期论文

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Ke Q#, Li L#, Yao X#, Lai X, Cai B, Chen H, Chen R, Zhai Z, Huang L, Li K, Hu A, Mao FF, Xiang AP, Tao L*, Li W*. Enhanced generation of human induced pluripotent stem cells by ectopic expression of Connexin 45. Sci Rep. 2017. Mar 28;7(1): p. 458. (IF:4.259) Ke Q#, Li W#, Lai X#, Chen H, Huang L, Kang Z, Li K, Ren J, Lin X, Zheng H, Huang W, Ma Y, Xu D, Chen Z, Song X, Lin X, Zhuang M, Wang T, Zhuang F, Xi J, Mao FF, Xia H, Lahn BT, Zhou Q*, Yang S*, Xiang AP*. TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Cell Res. 2016 Sep;26(9):1048-61. (IF:15.606) Ma Y#, Li J#, Wang G#, Ke Q#, Qiu S, Gao L, Wan H, Zhou Y, Xiang A P, Huang Q, Feng G*, Zhou Q*, Yang S*. Efficient production of cynomolgus monkeys with a toolbox of enhanced assisted reproductive technologies. Sci Rep, 2016 May 13. 6: p. 25888. (IF:4.259) Ke Q#, Li L#, Cai B#, Liu C, Yang Y, Gao Y, Huang WJ, Yuan XF, Wang T, Zhang Q, Harris AL, Tao L, Xiang AP*. Connexin 43 is involved in the generation of human induced pluripotent stem cells. Hum Mol Genet. 2013 Jun 1;22(11):2221-33. (IF:5.340) Cheng F#, Ke Q#, Chen F#, Cai B, Gao Y, Ye C, Wang D, Zhang L, Lahn BT, Li W, Xiang AP*. Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials. 2012 Apr;33(11):3195-204. (IF:8.402) Zhang Y#, Wang J#, Huang W#, Cai J#, Ba J, Wang Y, Ke Q, Huang Y, Liu X, Qiu Y, Lu Q, Sui X, Shi Y, Wang T, Shen, H, Guan Y, Zhou Y, Chen Y, Wang M, Xiang AP*. Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation. Nature Communications, 2018. 9(1). (IF:12.353) Wang J#, Liu X#, Qiu Y#, Shi Y, Cai J, Wang B, Wei X, Ke Q, Sui X, Wang Y, Huang Y, Li H, Wang T, Lin R, Liu Q, Xiang AP*. Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells. J Hematol Oncol. 2018 Jan 22;11(1):11. (IF:6.350) Wang J#, Huang Y#, Cai J#, Ke Q, Xiao J, Huang W, Li H, Qiu Y, Wang Y, Zhang B, Wu H, Zhang Y, Sui X, Bardeesi ASA, Xiang AP*. A Nestin-Cyclin-Dependent Kinase 5-Dynamin-Related Protein 1 Axis Regulates Neural Stem/Progenitor Cell Stemness via a Metabolic Shift. Stem Cells. 2018 Jan 3. doi: 10.1002/stem.2769. (IF:5.599) Zhang C, Liao W, Cai B, Liu F, Ke Q, Zhu X, He X, Hu A*. The similarities between smDCs and regDCs in alleviating the immune injury caused by transplantation of hepatocytes differentiated from ESCs, Stem Cell Res Ther, 2017.11.21, 8(1): 266~266. (IF:4.211) Li W#, Huang L#, Zeng J#, Lin W, Li K, Sun J, Huang W, Chen J, Wang G, Ke Q, Duan J, Lai X, Chen R, Liu M, Liu Y, Wang T, Yang X, Chen Y, Xia H*, Xiang AP*. Characterization and transplantation of enteric neural crest cells from human induced pluripotent stem cells. Mol Psychiatry. 2016 Oct 25. doi: 10.1038/mp.2016.191. (IF:13.204) Wang J#, Cai J#, Huang Y#, Ke Q, Wu B, Wang S, Han X, Wang T, Wang Y, Li W, Lao C, Song W, Xiang AP*. Nestin regulates proliferation and invasion of gastrointestinal stromal tumor cells by altering mitochondrial dynamics. Oncogene. 2016 Jun 16;35(24):3139-50. (IF:7.519) Li W#, Huang L#, Lin W#, Ke Q, Chen R, Lai X, Wang X, Zhang J, Jiang M, Huang W, Wang T, Yang X, Chen Y, Song W*, Xiang AP*. Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells. Biomaterials. 2015 Jan;39:75-84. (IF:8.402)