金正京 - 中山大学 - 中山医学院

个人简介

金正京教授于2006年获得美国密歇根州立大学细胞与分子生物学博士学位。完成New England Biolabs、宾夕法尼亚大学和美国国立卫生研究院的博士后研究工作后，她于2013年全职加入中山眼科中心国家重点实验室。金教授在肿瘤细胞生物学和表观遗传学等方面的研究成果多次发表于Science、Nucleic Acids Res、Cancer Cell等期刊。

研究领域

金教授课题组将着眼于研究眼科肿瘤形成的遗传学和表观遗传学机制，涉及肿瘤细胞生物学、生物化学和表观遗传学等多个领域。

近期论文

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Aggarwal P, Vaites L, Kim JK, Mellert H, Gurung B, Nakagawa H, Herlyn M, Hua X, Rustgi A, McMahon SB, and Diehl JA (2010). Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell 18(4):329-40. Koo SC, Moon BC, Kim JK, Kim CY, Sung SJ, Kim MC, Cho MJ, and Cheong YH (2009) OsBWMK mediates SA-dependent defense responses by activating the transcription factor OsWRKY33. Biochem Biophys Res Commun. 387(2):365-370. Kim JK and Diehl JA (2009) Nuclear cyclin D1: An oncogenic driver in human cancer. J Cell Physiol. 220(2): 292-296. Kim JK, Esteve P, Jacobsen SE, and Pradhan S (2009) UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. Nucleic Acids Res. 37(2): 493-505. Kim JK, Samaranayake M, and Pradhan S (2009) Epigenetic mechanisms in mammals. Cell Mol. Life Sci. 66(4): 596-612. Bostick M*, Kim JK*, Esteve P, Clark A., Pradhan, S, and Jacobsen SE (2007) UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317: 1760-1764 ( * : equally contributed to the work; Commented in Ooi SK and Bestor TH (2008) Cytosine methylation: remaining faithful. Curr. Biol.18: R174-6). Uhal BD, Kim JK, Li X, Molina-Molina M (2007) Angiotensin-TGF-beta1 crosstalk in human idiopathic pulmonary fibrosis: autocrine mechanisms in myofibroblasts and macrophages. Curr. Pharm. Des. 13: 1247-1256. Quiroz S, Kim JK, Mulrooney SB, and Hausinger RP (2007) “Chaperones of nickel metabolism” in Nickel and Its Surprising Impact in Nature, Vol. 2 of Metal Ions in Life Sciences; A. Sigel, H. Sigel, R. K. O. Sigel, Eds.; John Wiley & Sons, Ltd., Chichester, UK. Kim JK, Mulrooney SB, and Hausinger RP (2006) Functional fusion of UreE and UreF urease accessory proteins in Klebsiella aerogenes. J. Bacteriol.188: 8413-8420. Kim JK, Mulrooney SB, and Hausinger RP (2005) Biosynthesis of active Bacillus subtilis urease in the absence of known urease accessory proteins. J. Bacteriol. 187: 7150-7154.