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个人简介

2002年09月– 2006年06月 中山大学生命科学学院(获理学学士学位); 2007年04月– 2007年07月 瑞典Linkoping大学,交流学生; 2006年09月– 2011年06月 中山大学生化与分子生物学专业(获理学博士学位); 2011年08月– 2013年08月 中山大学生命科学学院,师资博士后; 2013年08月–2014年01月 中山大学生命科学学院,讲师; 2014年01月–至今 中山大学生命科学学院,副教授

研究领域

肿瘤免疫

近期论文

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1.CD169 identifies an anti-tumor macrophage subpopulation in human hepatocellular carcinoma. Zhang Y, Li JQ, Jiang ZZ, Li L, Wu Y(共通), Zheng L. J Pathol. 2016, 239: 231-241. (IF: 7.59) 2.c-Met identifies a population of matrix metalloproteinase 9-producing monocytes in peritumoural stroma of hepatocellular carcinoma. Zhao L, Wu Y(共一), Xie XD, Chu YF, Li JQ, Zheng L. J Pathol. 2015, 237: 319-329. (IF: 7.59) 3.Increased autophagy sustains the survival and pro-tumourigenic effects of neutrophils in human hepatocellular carcinoma. Li XF, Chen DP, Ouyang FZ, Chen MM, Wu Y, Kuang DM, Zheng L. J Hepatol. 2014, 62: 131-139.(IF: 9.86) 4.B7-H1–expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets. Kuang DM, Xiao X, Zhao Q, Chen MM, Li XF, Liu RX, Wei Y, Ouyang FZ, Chen DP, Wu Y, Lao XM, Deng H, Zheng L. J Clin Invest. 2014, 124: 4657–4667.(IF: 13.76) 5.MicroRNA-17, 20a regulates the proangiogenic function of tumor-associated macrophages via targeting hypoxia-inducible factor 2α. Xu Z, Zhao L, Zhu LY, He M, Zheng L, Wu Y(通讯).PloS One. 2013, 8: e77890.(IF: 3.73) 6.Monocyte/macrophage-elicited NK cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions. Wu Y(第一), Kuang DM, Pan WD, Wan YL, Lao XM, Wang D, Li XF, Zheng L. Hepatology. 2013, 57: 1107-1116.(IF:12) 7.Dynamic education of macrophages in different areas of human tumors. Wu Y(第一), Zheng L. Cancer Microenviron. 2012, 5: 195-201. 8.Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages. Zhao Q, Kuang DM, Wu Y, Xiao X, Li XF, Li TJ, Zheng L. J Immunol. 2012, 188: 1117-1124.(IF: 5.52) 9.Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop. Wu Y(第一), Zhao Q, Peng C, Sun L, Li XF, Kuang DM. J Pathol. 2011, 225: 438-447.(IF: 7.59) 10.Interleukin-17-educated monocytes suppress cytotoxic T-cell function through B7-H1 in hepatocellular carcinoma patients. Zhao Q, Xiao X, Wu Y, Wei Y, Zhu LY, Zhou J, Kuang DM. Eur J Immunol. 2011, 41: 2314-2322.(IF: 4.97) 11.Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. Kuang DM, Zhao Q, Wu Y, Peng C, Wang J, Xu Z, Yin XY, Zheng L. J Hepatol. 2011, 54: 948-955.(IF: 9.86) 12.Tumor activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients. Kuang DM, Peng C, Zhao Q, Wu Y, Zhu LY, Wang J, Yin XY, Li L, Zheng L. J Immunol. 2010, 185: 1544-1549.(IF: 5.52) 13.Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory Th17 cells. Kuang DM, Peng C, Zhao Q, Wu Y, Chen M, Zheng L. Hepatology. 2010, 51: 154-164.(IF: 12) 14.Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes. Kuang DM, Wu Y, Chen N, Cheng J, Zhuang SM, Zheng L. Blood. 2007, 110: 587-595.(IF: 9.06)

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