研究领域

Biophysical/Chemical Biology

The Baird laboratory employs a broad range of biophysico-chemical methods to investigate the structure and molecular mechanisms of cell surface receptors that operate in immunological and other responses. How are complex cellular responses controlled in time and space? Our biophysical characterization is carried out in conjunction with extensive measurements of cellular activities to determine the features critical for the initiation and regulation of signal transduction. A particular area of interest is the role of cellular membranes in targeting these responses. Many of our current studies focus on signaling pathways initiated by the receptor (FceRI) for immunoglobulin E (IgE) that plays a central role in allergic and inflammatory responses and serves as a model for other types of immune receptors. We apply similar methods to other receptors, currently including growth factor receptors involved in cancer. The goal of our integrated studies is to elucidate complex biological systems on a molecular level; the information obtained also has important biomedical applications in drug design and clinical therapies.

近期论文

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localized Epidermal Growth Factor Receptors Confer Ligand-independent Cell Transformation. J. Biol. Chem. 288(48): 34930-34942, 2013. (DOI) Smith, N.L., D.S. Abi Abdallah, B.A. Butcher, E.Y. Denkers, B. Baird and D. Holowka: Toxoplasma gondii Inhibits Mast Cell Degranulation by Suppressing Phospholipase Cg–mediated Ca2+ Mobilization. Front. Microbiol. 4: 179, 2013. (DOI) Midthun, K.M., P.G. Taylor, C. Newby, M. Chatzichristidi, P.S. Petrou, J.-K. Lee, S.E. Kakabakos, B.A. Baird and C.K. Ober: Orthogonal Patterning of Multiple Biomolecules Using an Organic Fluorinated Resist and Imprint Lithography. Biomacromolecules 14(4): 993-1002, 2013. (DOI) Santos, M.deS., R.M.Z.G. Naal, B. Baird and D. Holowka: Inhibitors of PI(4,5)P2 Synthesis Reveal Dynamic Regulation of IgE Receptor Signaling by Phosphoinositides in RBL Mast Cells. Mol. Pharmacol. 83(4): 793-804, 2013. (DOI) Doss, J., O. Olubi, B. Sannigrahi, M.D. Williams, D. Gadi, B. Baird and I. Khan: Procedure for Fabricating Biofunctional Nanofibers. J. Vis. Exp. 67: e4135, 2012. (DOI) Welch, M. Elizabeth, Y. Xu, H. Chen, N. Smith, M.E. Tague, H.D. Abruña, B. Baird and C.K. Ober: Polymer Brushes as Functional, Patterned Surfaces for Nanobiotechnology. J. Photopolym. Sci. Technol. 25(1): 53-56, 2012. (DOI) Lee, J., S.L. Veatch, B. Baird and D. Holowka: Molecular Mechanisms of Spontaneous and Directed Mast Cell Motility. J. Leukoc. Biol. 92(5): 1029-1041, 2012. (DOI) Holowka, D., N. Calloway, R. Cohen, D. Gadi, J. Lee, N.L. Smith and B. Baird: Roles for Ca2+ Mobilization and its Regulation in Mast Cell Functions. Front. Immunol. 3: 104, 2012. (DOI) Reuven, D., D. Sil, B. Sannigrahi, X-Q Wang, B. Baird and I.M. Khan: Archetypical Conductive Polymer Structure for Specific Interaction with Proteins. J. Macromol. Sci. (Part A: Pure & Appl. Chem.) 49(4): 330-338, 2012. (DOI) Veatch, S., E. Chiang, P. Sengupta, D. Holowka and B. Baird: Quantitative Nano-Scale Analysis of IgE-FcεRI Clustering and Coupling to Early Signaling Proteins. J. Phys. Chem. B 116(23): 6923-6935, 2012. (DOI) Veatch, S.L., B.B. Machta, S.A. Shelby, E.N. Chiang, D.A. Holowka and B.A. Baird: Correlation Functions Quantify Super-resolution Images and Estimate Apparent Clustering Due to Over-counting. PLoS One 7(2): e31457, 2012. (DOI) Cohen, R., K. Corwith, D. Holowka and B. Baird: Spatiotemporal Resolution of Mast Cell Granule Exocytosis Reveals Correlation with Ca2+ Wave Initiation. J. Cell Sci. 25(12): 2986-2994, 2012. (DOI) Gadi, D., A. Wagenknecht-Wiesner, D. Holowka and B. Baird: Sequestration of Phosphoinositides by Mutated MARCKS Effector Domain Inhibits Stimulated Ca2+ Mobilization and Degranulation in Mast Cells. Mol. Biol. Cell 22(24): 4908-4917, 2011. (DOI) Chiang, Y-W, A.J. Costa-Filho, B.A. Baird and J.H. Freed: 2D-ELDOR Study of Heterogeneity and Domain Structure Changes in Plasma Membrane Vesicles Upon Crosslinking of IgE Receptors. J. Phys. Chem. B 115(35): 10462-10469, 2011. (DOI) Calloway, N., T. Owens, K. Corwith, W. Rodgers, D. Holowka and B. Baird: Stimulated Association of STIM1 and Orai1 is Regulated by the Balance of PtdIns(4,5)P2 between Distinct Membrane Pools. J. Cell Sci. 124(15): 2602-2610, 2011. (DOI) Torres, A.J., D. Holowka and B.A. Baird: Micropatterned Ligand Arrays to Study Spatial Regulation in Fc Receptor Signaling. In Methods in Molecular Biology, Vol. 748 (Immune Receptors: Methods and Protocols, Eds., J.P. Rast and J.W.D. Booth), Chap. 14, pp. 195-207, 2011. Chiang, E.N., R. Dong, C.K. Ober and B.A. Baird: Cellular Responses to Patterned Poly(acrylic acid) Brushes. Langmuir 27(11): 7016-7023, 2011. (DOI) Kelly, C.V., B.A. Baird and H.G. Craighead: An Array of Planar Apertures for Near-Field Fluorescence Correlation Spectroscopy. Biophys. J. 100(7): L34-L36, 2011. (DOI) Brust-Mascher, I., B.A. Baird and W.W. Webb: Response to Kang et al. Biophys. J. 100(3): 793-794, 2011. (DOI) Suteewong, T., H. Sai, R. Cohen, S. Wang, M. Bradbury, B. Baird, S. Gruner and U. Wiesner: Highly Aminated Mesoporous Silica Nanoparticles with Cubic Pore Structure. J. Am. Chem. Soc. 133(2): 172-175, 2011. (DOI)