Sletten, Ellen M. - University of California, Los Angeles - Department of Chemistry & Biochemistry

个人简介

The Prof. Ellen Sletten received her BS in Chemistry from Stonehill College in 2006. She pursued her PhD at the University of California, Berkeley with Prof. Carolyn Bertozzi. Her thesis work involved the optimization and development of bioorthogonal chemistries and their subsequent applications in labeling living systems. Upon graduation in 2011, Prof. Sletten performed her postdoctoral studies in the laboratory of Prof. Tim Swager at the Massachusetts Institute of Technology as an NIH Postdoctoral Fellow. She joined the faculty at UCLA as an Assistant Professor and the John T. McTague Career Development Chair in 2015.

研究领域

The Sletten Group exploits the unique properties of fluorinated materials to develop diagnostic and therapeutic technologies. Research within the group encompasses an interdisciplinary mix of organic synthesis, fluorous chemistry, chemical biology, nanoscience, supramolecular chemistry, polymer synthesis, photophysics and pharmacology.

近期论文

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Niroui, F.; Wang, A.I.; Sletten, E.M.; Song, Y.; Kong, J.; Yablonovitch, E.; Swager, T.M.; Lang, J.H.; Bulovic, V. “Tunneling nanoelectromechanical switches based on compressible molecular thin films.” ACS Nano 2015, 9, 7886-7894. Zarzar, L.D.; Sresht, V.; Sletten, E.M.; Kalow, J.A.; Blankschtein, D.; Swager, T.M. “Dynamically reconfigurable complex emulsions via tunable interfacial tensions.” Nature 2015, 518, 520-524. Koo, B.; Sletten, E.M.; Swager, T.M. “Efficient synthesis of functionalized poly(3-hexylthiophenes)s via lithium-bromine exchange.” Macromolecules 2015, 48, 229-235. Sletten, E.M.; Swager, T.M. “Fluorofluorophores: fluorescent fluorous chemical tools spanning the visible spectrum.” J. Am. Chem. Soc. 2014, 136, 13574-13577. Sletten, E.M.; de Almeida, G.; Bertozzi, C.R. “A homologation approach to the synthesis of difluorinated cycloalkynes.” Org. Lett. 2014, 16, 1634-1637. Agarwal, P.; van der Weijden, J.; Sletten, E.M.; Rabuka, D.; Bertozzi, C.R. “A Pictet-Spengler ligation for protein chemical modification.” Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 46-51. Gordon, C.G.; Mackey, J.; Jewett, J.C.; Sletten, E.M.; Houk, K.N.; Bertozzi, C.R. “Reactivity of biarylazacyclooctynones in copper-free click chemistry.” J. Am. Chem. Soc. 2012, 134, 9199-9208. Yao, J.Z.; Uttamapinant, C.; Poloukhtine, A.; Baskin, J.M.; Codelli, J.A.; Sletten, E.M.; Bertozzi, C.R.; Popik, V.V.; Ting, A,Y. “Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition.” J. Am. Chem. Soc. 2012, 134, 3720-3728. de Almeida, G.; Sletten, E.M.; Nakamura, H.; Palaniappan, K.K.; Bertozzi, C.R. “Thiacycloalkynes for Cu-free click chemistry.” Angew. Chem. Int. Ed. 2012, 51, 2443-2447.