Xiao, Grace - University of California, Los Angeles

研究领域

With similar number of genes as in simpler organisms, mammals demonstrate an amazing degree of phenotypic diversity. Mammalian gene expression is under tight regulation temporally and spatially, which contributes to the formation of different cell types, tissues, and organs. Gene regulation involves a complex network of players, including multiple DNA, RNA sequence elements and RNA and protein factors. These regulators interact with each other and carry out combinatorial regulatory functions. Our lab uses both computational and experimental approaches to study the biology of gene regulation from a systems point of view. Our current focus pertains to the regulation of gene expression at the RNA level via the process of pre-mRNA splicing and other post-transcriptional (or co-transcriptional) mechanisms. Splicing is a critical step enabling diversity in gene expression programs. More than 90% of all human genes undergo alternative splicing which allows multiple gene products with potentially different functions to be produced from a single gene locus. We are currently investigating splicing regulatory mechanisms using comparative genomics, high-throughput technologies, such as deep sequencing and microarrays, and systems level computational analysis, such as system identification and modeling approaches. A long-term goal of our research is to better understand the involvement of splicing in gene expression programs of different disease models.

近期论文

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Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, Vondriska T, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y, "A long non-coding RNA defines an epigenetic checkpoint for cardiac hypertrophy", Nature Medicine, (2016) . Meng Q, Ying Z, Noble E, Zhao Y, Agrawal R, Mikhail A, Zhuang Y, Tyagi E, Zhang Q, Lee JH, Morselli M, Orozco L, Guo W, Kilts TM, Zhu J, Zhang B, Pellegrini M, Xiao X, Young MF, Gomez-Pinilla F, Yang X, "Systems nutrigenomics reveals opposite actions of fructose and DHA on gene networks linking metabolism and brain function", eBiomedicine, 7 : 157-166 (2016) . Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn JY, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui WJ, Williams NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Schulze PC, Lynch C, Jain MK, Wang Y, "Catabolic defect of branched-chain amino acids promotes heart failure", Circulation, 133 (21): 2038-2049 (2016) . Fuxjager M, Lee JH, Chan TM, Bahn JH, Chew JG, Xiao X, Schlinger B, "Hormones, genes and athleticism: effect of androgens on the avian muscular transcriptome", Molecular Endocrinology, 30 (2): 254-271 (2016) . Gao C, Ren V, Lee JH, Qiu J, Chapski DJ, Rau CD, Zhou Y, Abdellatif M, Nakano A, Vondriska T, Xiao X, Fu XD, Chen JN, Wang Y, "RBFox1 mediated alternative RNA splicing regulates cardiac hypertrophy and heart failure", Journal of Clinical Investigation, 126 (1): 195-206 (2016) . Ahn J, Xiao X, "RASER: reads aligner for SNPs and editing sites of RNA", Bioinformatics, btv505 : 1-8 (2015) . Lin X, Lo HC, Wong DT, Xiao X, "Noncoding RNAs in human saliva as potential disease biomarkers", Frontiers in Genetics, 6 (175): 1-6 (2015) . Li Z, Yu J, Hosohama L, Nee K, Gkountela S, Chaudhari S, Cass AA, Xiao X, Clark AT, "The Sm protein methyltransferase PRMT5 is not required for primordial germ cell specification in mice", EMBO Journal, 34 (6): 748-758 (2015) .