Pellegrini, Matteo - University of California, Los Angeles

研究领域

Our lab is interested in the development of computational approaches to interpret genomic data. We seek to develop large-scale models of transcriptional and epigenetic regulation as well as signal transduction. Our approach is to build models that integrate varied data that sheds light on these phenomena. This data is produced using the latest generation of high throughput sequencers. Our research focuses on the development of both low and high-level analyses. For instance we are developing suites of tools for the analysis of high throughput sequencing data, including epigenomics and transcriptomics. Our goal is to make these tools, and the resulting databases, generally available to the scientific community.

近期论文

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Massoud AH, Charbonnier LM, Lopez D, Pellegrini M, Phipatanakul W, Chatila TA., "An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to T(H)17-like cells", Nat Med (2016). [link] Escuin-Ordinas H, Li S, Xie MW, Sun L, Hugo W, Huang RR, Jiao J, de-Faria FM, Realegeno S, Krystofinski P, Azhdam A, Komenan SM, Atefi M, Comin-Anduix B, Pellegrini M, Cochran AJ, Modlin RL, Herschman HR, Lo RS, McBride WH, Segura T, Ribas A, "Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors", Nat Commun 7: (2016). [link] Hoban MD, Lumaquin D, Kuo CY, Romero Z, Long J, Ho M, Young CS, Mojadidi M, Fitz-Gibbon S, Cooper AR, Lill GR, Urbinati F, Campo-Fernandez B, Bjurstrom CF, Pellegrini M, Hollis RP, Kohn DB, "CRISPR/Cas9-Mediated Correction of the Sickle Mutation in Human CD34+ cells", Mol Ther (2016). [link] Vega-Vaquero A, Bonora G, Morselli M, Vaquero-Sedas MI, Rubbi L, Pellegrini M, Vega-Palas MA, "Novel features of telomere biology revealed by the absence of telomeric DNA methylation", Genome Res 26 (8): 1047-1056 (2016). [link] Brumm AJ, Nunez S, Doroudchi MM, Kawaguchi R, Duan J, Pellegrini M, Lam L, Carmichael ST, Deb A, Hinman JD, "Astrocytes Can Adopt Endothelial Cell Fates in a p53-Dependent Manner", Mol Neurobiol (2016). [link] Lam L, Chin L, Halder RC, Sagong B, Famenini S, Sayre J, Montoya D, Rubbi L, Pellegrini M, Fiala M, "Epigenetic changes in T-cell and monocyte signatures and production of neurotoxic cytokines in ALS patients", FASEB J (2016). [link] Schokrpur S, Hu J, Moughon DL, Liu P, Lin LC, Hermann K, Mangul S, Guan W, Pellegrini M, Xu H, Wu L., "CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma", Sci Rep 6: (2016). [link]