Chow, Samson A. - University of California, Los Angeles

个人简介

Vice Chair, and Professor, Molecular & Medical Pharmacology Member, Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC)

研究领域

Retroviruses are RNA viruses that replicate through a DNA intermediate. In humans, infection by retroviruses can lead to AIDS, lymphoma, and leukemia. My present studies focus on understanding the molecular mechanisms of the integration reaction catalyzed by the viral protein, integrase, purified from the human immunodeficiency virus (HIV), and examining possible chromosomal instability as a result of retroviral integration. Owing to their integration properties, retroviruses are also widely used as vectors for genetic engineering and gene replacement therapy. Progress in understanding the mechanism of integration may lead to development of still more powerful tools for molecular medicine. A related project is aimed at introducing exogenous DNA into specific target sites by use of fusion proteins consisting of HIV integrase and sequence-specific DNA binding proteins. Other research interests include feline immunodeficiency virus (FIV) and the development of FIV infection in cats as a model for HIV infection and anti-retroviral therapy in humans.

近期论文

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Dobard, C.W., Briones, M. and Chow, S.A. Molecular mechanisms by which HIV-1 integrase stimulates the early steps of reverse transcription. J Virol 2007; 81: 10037-10046. Dong, B., Kim, S., Hong, S., Das Gupta, J., Malathi, K., Klein, E.A., Ganem, D., DeRisi, J., Chow, S.A. and Silverman, R.H. An infectious retrovirus susceptible to an interferon antiviral pathway from human prostate tumors. Pro Natl Acad Sci USA 2007; 104(5): 1655-1660. Vatakis, D.N., Bristol, G., Wilkinson, T.A., Chow, S.A. and Zack, J.A. Immediate activation to rescue efficient HIV replication in quiescent CD4+ T cells. J Virol 2007; 81: 3574-3582. Kim, S. Kim, Y. Liang, T. Sinsheimer, J. S. Chow, S. A. A high-throughput method for cloning and sequencing human immunodeficiency virus type 1 integration sites. J Virol. 2006; 80(22): 11313-21. Tan, W. Dong, Z. Wilkinson, T. A. Barbas, C. F., 3rd Chow, S. A. Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein E2C can bias integration of viral DNA into a predetermined chromosomal region in human cells. J Virol. 2006; 80(4): 1939-48. Brooks, D. G. Cohen, M. D. Jamieson, B. D. Poon, B. Kitchen, S. G. Chow, S. A. Chen, I. S. Zack, J. A. Koka, P. S. Rapid size dependent deletion of foreign gene sequences inserted into attenuated HIV-1 upon infection in vivo: implications for vaccine development. Curr HIV Res. 2005; 3(4): 377-92. Tan, W. Zhu, K. Segal, D. J. Barbas, C. F., 3rd Chow, S. A. Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites. J Virol. 2004; 78(3): 1301-13.