Black, Douglas L. - University of California, Los Angeles

个人简介

Dr. Black is a Professor in the Department of Microbiology, Immunology, and Molecular Genetics at the University of California, Los Angeles, and the David Geffen School of Medicine at UCLA. His B.A. degree is in chemistry from the University of California, Santa Cruz. He received his Ph.D. degree in molecular biochemistry and biophysics at Yale University, working with Joan Steitz. Prior to his appointment at UCLA, he worked with David Baltimore, Donald Rio, and Phil Sharp at the Whitehead Institute for Biomedical Research and MIT.

研究领域

Our lab works on a range of projects related to the control of pre-mRNA splicing in neurons and other cells. We aim to determine the mechanisms of action of splicing regulators, as well as to understand their roles in neural development and mature neuronal function. We have long-standing projects focused on two families of regulatory factors: the polypyrimidine tract–binding proteins (PTBP1 and PTBP2), and the Rbfox proteins (1, 2 and 3). Each of these RNA binding proteins alters the splicing of a specific set of gene transcripts in neurons, and each can induce different splicing outcomes depending on its binding context.

近期论文

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amianov Andrey, Ying Yi, Lin Chia-Ho, Lee Ji-Ann, Tran Diana, Vashisht Ajay A, Bahrami-Samani Emad, Xing Yi, Martin Kelsey C, Wohlschlegel James A, Black Douglas L Rbfox Proteins Regulate Splicing as Part of a Large Multiprotein Complex LASR Cell, 2016; 165(3): 606-19. Vuong Celine K, Black Douglas L, Zheng Sika The neurogenetics of alternative splicing Nature reviews. Neuroscience, 2016; 17(5): 265-81. Linares Anthony J, Lin Chia-Ho, Damianov Andrey, Adams Katrina L, Novitch Bennett G, Black Douglas L The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation eLife, 2015; 4(1): e09268. Sharma Shalini, Wongpalee Somsakul Pop, Vashisht Ajay, Wohlschlegel James A, Black Douglas L Stem-loop 4 of U1 snRNA is essential for splicing and interacts with the U2 snRNP-specific SF3A1 protein during spliceosome assembly Genes & development, 2014; 28(22): 2518-31. Li Qin, Zheng Sika, Han Areum, Lin Chia-Ho, Stoilov Peter, Fu Xiang-Dong, Black Douglas L The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation eLife, 2014; 3(22): e01201. Zheng Sika, Damoiseaux Robert, Chen Liang, Black Douglas L A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing Genome research, 2013; 23(6): 998-1007. Pandya-Jones Amy, Bhatt Dev M, Lin Chia-Ho, Tong Ann-Jay, Smale Stephen T, Black Douglas L Splicing kinetics and transcript release from the chromatin compartment limit the rate of Lipid A-induced gene expression RNA (New York, N.Y.), 2013; 19(6): 811-27. Zheng Sika, Gray Erin E, Chawla Geetanjali, Porse Bo Torben, O'Dell Thomas J, Black Douglas L PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2 Nature neuroscience, 2012; 15(3): 381-8, S1. Gehman Lauren T, Meera Pratap, Stoilov Peter, Shiue Lily, O'Brien Janelle E, Meisler Miriam H, Ares Manuel, Otis Thomas S, Black Douglas L The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function Genes & development, 2012; 26(5): 445-60. Bhatt Dev M, Pandya-Jones Amy, Tong Ann-Jay, Barozzi Iros, Lissner Michelle M, Natoli Gioacchino, Black Douglas L, Smale Stephen T Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions Cell, 2012; 150(2): 279-90. Gehman Lauren T, Stoilov Peter, Maguire Jamie, Damianov Andrey, Lin Chia-Ho, Shiue Lily, Ares Manuel, Mody Istvan, Black Douglas L The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain Nature genetics, 2011; 43(7): 706-11.