Teitell, Michael - University of California, Los Angeles

个人简介

Education BS, Biochemistry, University of California, Los Angeles, 1985 MS, Biochemistry, University of California, Los Angeles, 1985 PhD, Immunology, University of California, Los Angeles, 1991 MD, University of California, Los Angeles, 1993 Residency in Anatomic Pathology, Brigham & Women’s Hospital, 1995 Postdoctoral Fellowship, Harvard Medical School, Dr. Richard Blumberg, 1995 Residency in Clinical Pathology, University of California, San Francisco, 1997 Postdoctoral Fellowship, University of California, San Francisco, Dr. Joe Gray, 1997 Fellowship in Pediatric Pathology, Children’s Hospital Los Angeles, 1999 Clinical Instructorship, CHLA and UCLA, 1999

研究领域

Research in the Teitell lab began with studies on fundamental mechanisms of cancer formation and progression. This led to projects in stem and cancer cell metabolism and the collaborative development of new approaches in cell engineering and diagnostics. Currently active project areas in the group include: Mechanisms that control B cell differentiation into antibody-secreting plasma cells versus transformation into aggressive B cell leukemias and lymphomas in germinal centers Studies of a pathway for importing small non-coding RNAs into mitochondria to regulate cell respiration and energy production Metabolism and mitochondrial function in human pluripotent stem cells, which resembles metabolism in cancer cells Co-invention of (1) a photothermal nanoblade for delivering large cargo, such as mitochondria or intracellular pathogens, into mammalian cells and (2) a live cell interferometer, for dissecting cellular heterogeneity and profiling cell responses to environmental perturbations (e.g. therapeutics) in real-time These distinct areas of study converge on the common goal of increased understanding, diagnosis and treatment of human malignancies in the context of changes that arise compared to normal development and function.

近期论文

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Wu, Y.-C., Wu, T.-H., Clemens, D.L., Lee, B.-Y., Wen, X., Horwitz, M.A., Teitell, M.A., and Chiou, P.-Y. Massively Parallel Delivery of Large-Sized Cargo into Mammalian Cells with Light Pulses. Nature Methods, 12(5): 439-444, 2015 Teslaa, T and Teitell, M.A. Pluripotent Stem Cell Energy Metabolism: An Update. EMBO J, 34(2): 138-153, 2015 Zangle, T.A. and Teitell, M.A. Live Cell Mass Profiling: An Emerging Approach in Quantitative Biophysics. Nature Methods, 11(12): 1221-1228, 2014 Zangle, T.A., Chun, J., Zhang, J., Reed, J., and Teitell, M.A. Quantification of Biomass and Cell Motion in Human Pluripotent Stem Cell Colonies. Biophysical Journal, 105:593-601, 2013 Dabir, D., Hasson, S.A., Setoguchi, K., Johnson, M.E., Wongkongkathep, P., Douglas, C.J., Zimmerman, J., Damoiseaux, R., Teitell, M.A., and Koehler, C.M. MitoBloCK-6: A Small Molecule Inhibitor of Redox-Regulated Protein Translocation in Mitochondria. Developmental Cell, 25:81-92, 2013 Zhang, J., Nuebel, E., Daley, G.Q., Koehler, C.M., and Teitell, M.A. Metabolic Regulation in Pluripotent Stem Cells During Reprogramming and Self-Renewal. Cell Stem Cell, 11:589-595, 2012 Zhang, J., Nuebel, E., Wisidagama, D.R.R., Setoguchi, K., Hong, J.S., Van Horn, C. M., Imam, S.S., Vergnes, L., Malone, C.S., Koehler, C.M., and Teitell, M.A. Measuring Energy Metabolism in Cultured Cells, Including Human Pluripotent Stem Cells and Differentiated Cells. Nature Protocols, 7:1068-1085, 2012 Zhang, J., Khvorostov, I., Hong, J.S., Oktay, Y., Vergnes, L., Nuebel, E., Wahjudi, P.N., Setoguchi, K., Wang, G., Do, A., Jung, H.-J., McCaffery, J.M., Kurland, I.J., Reue, K., Lee, W.N.P., Koehler, C.M., and Teitell, M.A. UCP2 Regulates Energy Metabolism and Differentiation Potential of Human Pluripotent Stem Cells. EMBO Journal, 30:4860-4873, 2011 Huang, Y., Park, Y., Wang-Zhu, Y., Larange, A., Arens, R., Bernardo, I., Olivares-Villagomez, D., Mendez-Fernandez, Y.V., Herndler-Brandstetter, D., Abraham, N., Grubeck-Loebenstein, B., Schoenberger, S.P., Van Kaer, L., Kronenberg, M., Teitell, M. A., and Cheroutre, H. Affinity-Based Selection of Mucosal CD8 Memory T Cells by an MHC Class I Molecule. Nature Immunology, 12:1086-1095, 2011 Reed, J., Chun, J., Zangle, T.A., Kalim, S., Hong, J.S., Pefley, S.E., Zheng, X., Gimzewski, J.K., and Teitell, M.A. Rapid, Massively Parallel Single-Cell Drug Response Measurements Via Live Cell Interferometry. Biophysical Journal, 101:1025-1031, 2011