Kasko, Andrea M. - University of California, Los Angeles

个人简介

Education B.S., University of Michigan, Ann Arbor, 1997 M.S.E., Case Western Reserve University, 1999 Ph.D., The University of Akron, 2004 Postdoctoral Research Associate, Howard Hughes Medical Institute, University of Colorado, Boulder, 2004-2006 Awards and Recognitions Doc Stevenson Award for Outstanding Faculty in Residence, 2012, 2014 NIH Director’s New Innovator Award, 2011 UCLA Faculty Career Award, 2007-2008 Howard Hughes Postdoctoral Research Fellow, 2006 Good Year Tire and Rubber Fellowship, 2003

研究领域

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Structural hierarchy is an important concept in the design of new materials for biomedical applications. Because natural materials exhibit structural hierarchy from the nanoscale to the macroscale, biomaterials should ideally exhibit a similar hierarchy. Current research in biomaterials is often limited to chemicals available “off the shelf”, which are either naturally occurring materials or biocompatible synthetic polymers. Collagen, heparin, hyaluronic acid, and agarose are examples of natural materials used for biomedical applications, but there is limited control over their chemical and physical properties and thus they are only suitable for specific applications. Poly(ethylene glycol) (PEG), poly(vinyl alcohol), poly(caprolactone) and poly(D,L-lactic-co-glycolic acid) are examples of biocompatible synthetic polymers with the physical and chemical behaviors that can be controlled and/or modified, but that exhibit very little structural hierarchy. In order to mimic, influence or control natural processes, we need to rationally design new materials from the nanoscale to the macroscale, with control over the chemical and physical properties at multiple levels. By controlling molecular structure, assembly and interaction on multiple levels, we can better replicate the critical aspects of physiological materials and processes.