个人简介

B.S. Biochemistry, New Mexico State University 1998 B.A. Chemistry, New Mexico State University 1998 Ph.D. University of Texas M.D. Anderson Cancer Center 2004 Postdoctoral Research, Rice University 2006 Postdoctoral Research, Los Alamos National Laboratory 2009 College Assistant Professor, NMSU 2011

研究领域

Biochemistry

The research efforts in my laboratory involve investigations regarding the molecular function of ovarian hormones such as estrogen in cancers and tumors (e.g. breast cancer, uterine leiomyoma). Uterine leiomyomas are very common benign tumors that occur in most premenopausal women. These lesions are symptomatic in approximately 25% of affected women and require surgery for treatment. The long-term goal of the research in my laboratory is to identify molecular therapeutic approaches to treat uterine leiomyoma and other ovarian hormone dependent lesions. To this end, we use uterine leiomyoma cells and tissues derived from the Eker rat model of uterine leiomyoma in combination with biochemical and molecular biology techniques to determine the mechanisms of ovarian hormone action in this tumor type. Specifically, my research group is interested in understanding the role of GPR30, a recently identified, non-nuclear estrogen receptor, in the development and growth of uterine leiomyoma. Additionally, research in my laboratory is aimed at determining a potential role of GPR30 in the uterus during pregnancy and parturition (childbirth).

近期论文

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Houston, K.D.* Mack, N.H., Doorn, S.K., Park, M.S. “Macrophage cells secrete specific cytokines and accumulate activated interferon regulatory factor 3 after multi-walled carbon nanotube exposure”. *corresponding author (submitted) Li, W., Vacca, G., Castillo, M., Houston, K.D., and Houston, J.P. “Fluorescence Lifetime Excitation Cytometry by Kinetic Dithering”. Electrophoresis, (in press) Vaziri Gohar, A., Cao, R., Jenkins, P., Li, W., Houston J.P., Houston, K.D. “Subcellular localization- dependent changes in EGFP fluorescence lifetime measured by time-resolved flow cytometry”. Biomedical Optics Express, 4 1390-1400 (2013). Short, J.D., Dere, R., Houston, K.D., Cai, S., Kim, J., Bergeron, J.M., Shen, J., Liang, J., Tamanoi, F., Bedford, M.T., Mills, G.B., and Walker, C.L. “Stabilization of p27 by Constitutive AMPK Activation in Tsc2-deficient Cells via Phosphorylation at T197 and Binding of 14-3-3 Proteins”. Molecular Carcinogenesis 49:429 – 439 (2010). Houston, K.D., Mack, N.H., Wang, H-L., Doorn, S.K., Park, M.S. “Identification of Biomarkers for Multi-walled Carbon Nanotube Exposure in Mouse Macrophage Cells”. Proceedings of the 25th Southern Biomedical Engineering Conference, IFMBE Proceedings 24, 111–112 (2009). Short, J.D.*, Houston, K.D.*, Dere, R., Cai, S., Kim J., Johnson, C.L., Broaddus, R.R., Shen, J., Miyamoto, S., Tamanoi, F., Kwiatkowski, D., Mills, G.B., and Walker, C.L. “AMP-Activated Protein Kinase Signaling Results in Cytoplasmic Sequestration of p27”. Cancer Research 68, 6496-6506 (2008). * These authors contributed equally to this publication. Bakthavatsalam, D., Brock, D. A., Nikravan, N.N., Houston, K.D., Hatton, R.D., and Gomer, R.H. “A Secreted Cathepsin-like Protein is a Dictyostelium Chalone”. Journal of Cell Science 121, 2473-2480 (2008). Houston, K.D., Copland, J.A., Broaddus, R.R., Gottardis, M.M., Fischer, S.M., and Walker C.L. “Inhibition of Proliferation and Estrogen Receptor Signaling by Peroxisome Proliferator-activated Receptor  Ligands in Uterine leiomyoma”. Cancer Research 63, 1221-1227 (2003). Cesen-Cummings, K., Houston, K.D., Copland, J.A., Moorman, V.J., Walker, C.L., and Davis, B.J. “Uterine Leiomyomas Express Myometrial Contractile-Associated Proteins Involved in Pregnany-Related Hormone Signaling”. Journal of the Society for Gynecologic Investigation 10, 11-20 (2003). Hodges, L.C., Houston, K.D., Fuchs-Young, R., Zhang, Z., Winneker, R.C., and Walker, C.L. “Transdominant Suppression of Estrogen Receptor Signaling by Progesterone Receptor Ligands in Uterine Leiomyoma Cells”. Molecular and Cellular Endocrinology 196, 11-20 (2002). Houston, K.D., Hunter D.S, Hodges, L.C. and Walker C. L. “Uterine Leiomyomas: Mechanisms of Tumorigenesis”. Toxicologic Pathology 29, 100-104 (2001).