Solari, Roberto - Imperial College London - National Heart & Lung Institute

个人简介

Roberto Solari is a Visiting Professor within the Infection in Airway Disease research group, Respiratory Infections section within the National Heart and Lung Institute. Professor Solari obtained his first class BSc from Nottingham University in 1978 followed by his PhD in 1981 for which he studied the receptor mediated transmission of IgG from mothers to neonates via intestinal uptake. He went on to do a post-doc at the Institut de Biochimie, University of Lausanne funded by a Royal Society European Fellowship and followed this with a second post-doc in the Department of Cell Biology, Liverpool University. Both postdoctoral positions researched the receptor mediated transepithelial transport of dimeric IgA into mother’s milk. In 1986, Professor Solari joined Glaxo and worked on inflammation and allergy drug discovery. He has since held a number of research posts in industry working from target discovery through to human clinical trials. Most recently, he was Vice President in the Respiratory Therapy Area at GSK leading a unit working the discovery of novel asthma drugs. Roberto has also been involved with the creation of UK start-up companies such as Astex Pharmaceuticals, Lorantis, Chroma Therapeutics and Heptares.

研究领域

His industrial research interests have broadly been in drug discovery in inflammation and allergy, but as a cell biologist his main scientific interest has been in the functioning of the secretory pathway. His current research is on the interaction between human Rhinovirus and the host cell in particular how the virus hijacks the cellular ER and Golgi membranes in order to replicate. The aim is to discover novel targets to allow the development of anti-viral drugs.

近期论文

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Custovic A, Belgrave D, Lin L, Bakhsoliani E, Telcian AG, Solari R, Murray CS, Walton RP, Curtin J, Edwards MR, Simpson A, Rattray M, Johnston SLclose, 2018, Cytokine Responses to Rhinovirus and Development of Asthma, Allergic Sensitization, and Respiratory Infections during Childhood., Am J Respir Crit Care Med, Vol: 197, Pages: 1265-1274 Mousnier A, Bell AS, Swieboda DP, Morales-Sanfrutos J, Perez-Dorado I, Brannigan JA, Newman J, Ritzefeld M, Hutton JA, Guedan A, Asfor AS, Robinson SW, Hopkins-Navratilova I, Wilkinson AJ, Johnston SL, Leatherbarrow RJ, Tuthill TJ, Solari R, Tate EWclose, 2018, Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus, NATURE CHEMISTRY, Vol: 10, Pages: 599-606, ISSN: 1755-4330 Guedan A, Swieboda D, Charles M, Toussaint M, Johnston SL, Asfor A, Panjwani A, Tuthill TJ, Danahay H, Raynham T, Mousnier A, Solari Rclose, 2017, Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication, JOURNAL OF VIROLOGY, Vol: 91, ISSN: 0022-538X Toussaint M, Jackson DJ, Swieboda D, Guedan A, Tsourouktsoglou T-D, Ching YM, Radermecker C, Makrinioti H, Aniscenko J, Edwards MR, Solari R, Farnir F, Papayannopoulos V, Bureau F, Marichal T, Johnston SLclose, 2017, Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation, NATURE MEDICINE, Vol: 23, Pages: 681-+, ISSN: 1078-8956 Anderson CA, Solari R, Pease JE, 2016, Biased agonism at chemokine receptors: obstacles or opportunities for drug discovery?, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 99, Pages: 901-909, ISSN: 0741-5400 Carlile GW, Robert R, Matthes E, Yang Q, Solari R, Hatley R, Edge CM, Hanrahan JW, Andersen R, Thomas DY, Birault Vclose, 2016, Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity, MOLECULAR PHARMACOLOGY, Vol: 90, Pages: 65-79, ISSN: 0026-895X McErlean P, Kelly A, Dhariwal J, Watson J, Jurdzinski N, Smith J, Solari R, Edwards MR, Van Oosterhout A, Johnston SL, Lavender Pclose, 2016, EPIGENETIC LANDSCAPE OF THE ASTHMATIC AIRWAYS, Publisher: BMJ PUBLISHING GROUP, Pages: A214-A214, ISSN: 0040-6376 Robertson AL, Ogryzko NV, Henry KM, Loynes CA, Foulkes MJ, Meloni MM, Wang X, Ford C, Jackson M, Ingham PW, Wilson HL, Farrow SN, Solari R, Flower RJ, Jones S, Whyte MKB, Renshaw SAclose, 2016, Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen, DISEASE MODELS & MECHANISMS, Vol: 9, Pages: 621-632, ISSN: 1754-8403 Solari R, Pease JE, 2015, Targeting chemokine receptors in disease - a case study of CCR4, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 763, Pages: 169-177, ISSN: 0014-2999 Solari R, Pease JE, Begg M, 2015, "Chemokine receptors as therapeutic targets: Why aren't there more drugs?", EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 746, Pages: 363-367, ISSN: 0014-2999 Xie W, Pariollaud M, Wixted WE, Chitnis N, Fornwald J, Truong M, Pao C, Liu Y, Ames RS, Callahan J, Solari R, Sanchez Y, Diehl A, Li Het al., 2015, Identification and Characterization of PERK Activators by Phenotypic Screening and Their Effects on NRF2 Activation, PLOS ONE, Vol: 10, ISSN: 1932-6203 Ajram L, Begg M, Slack R, Cryan J, Hall D, Hodgson S, Ford A, Barnes A, Swieboda D, Mousnier A, Solari Rclose, 2014, Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists, EUROPEAN JOURNAL OF PHARMACOLOGY, Vol: 729, Pages: 75-85, ISSN: 0014-2999 Carlile GW, Robert R, Matthes E, Solari R, Anderson R, Edge C, Hanrahan JW, Birault V, Thomas DYclose, 2014, BIOLOGICAL EVALUATION OF LATONDUINE ANALOGUES AS CORRECTORS OF MUTANT CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CHANNELS BY INHIBITION OF PARP-3 AND PARP-16, PEDIATRIC PULMONOLOGY, Vol: 49, Pages: 294-294, ISSN: 8755-6863 Deakin A, Duddy G, Wilson S, Harrison S, Latcham J, Fulleylove M, Fung S, Smith J, Pedrick M, McKevitt T, Felton L, Morley J, Quint D, Fattah D, Hayes B, Gough J, Solari Rclose, 2014, Characterisation of a K390R ITK Kinase Dead Transgenic Mouse - Implications for ITK as a Therapeutic Target, PLOS ONE, Vol: 9, ISSN: 1932-6203 Mousnier A, Swieboda D, Pinto A, Guedan A, Rogers AV, Walton R, Johnston SL, Solari Rclose, 2014, Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion, JOURNAL OF VIROLOGY, Vol: 88, Pages: 11671-11685, ISSN: 0022-538X Privolizzi R, Solari R, Johnston SL, McLean GRclose, 2014, The application of prophylactic antibodies for rhinovirus infections., Antivir Chem Chemother, Vol: 23, Pages: 173-177 Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, Sawtell AK, Hamza B, Willson J, Walmsley SR, Anderson SR, Coles MC, Farrow SN, Solari R, Jones S, Prince LR, Irimia D, Rainger GE, Kadirkamanathan V, Whyte MKB, Renshaw SAclose, 2014, A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism, SCIENCE TRANSLATIONAL MEDICINE, Vol: 6, ISSN: 1946-6234