Parks, Robin - University of Ottawa - Department of Biochemistry, Microbiology and Immunology

个人简介

Dr. Parks completed a M.Sc. and Ph.D. in the Department of Molecular Biology and Genetics, University of Guelph (Guelph, Ontario), working on biochemical and genetic characterization of poxvirus replication and recombination. In 1996, Dr. Parks began a Postdoctoral Fellowship with Dr. Frank L. Graham, in the Departments of Biology and Pathology, McMaster University (Hamilton, Ontario), working on the development of novel adenoviral vectors for use as gene delivery vehicles for gene therapy applications. Dr. Parks joined the Ottawa Hospital Research Institute in January 1999.

研究领域

Development and characterization of adenoviral vectors deleted of all viral protein coding sequences for use in gene therapy. Characterization of host immune responses to gene therapy vectors and foreign (therapeutic) proteins. Investigating novel therapeutics for the treatment and correction of muscular dystrophies and cancer

近期论文

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79. Holterman, C., J.-F. Thibodeau, C. Towaij, A. Gutsol, R.J. Parks, M. Cooper, R. Touyz and C. Kennedy (2014) Nephropathy and elevated blood pressure in transgenic mice with podocyte-specific Nox5 expression. Journal of the American Society of Nephrology 25:784-97. 80. Zlebnik, N.E., S. Brimijoin, Y. Gao, A.T. Saykao, R.J. Parks, and M.E. Carroll (2014) Long-term reduction of cocaine self-administration in rats treated with adenoviral vector-delivered cocaine hydrolase: evidence for enzymatic activity. Neuropsychopharmacology 9:1538-46. 81. Puppo, A., G. Cesi, E. Marrocco, P. Piccolo, S. Jacca, D.M. Shayakhmetov, R.J. Parks, B.L. Davidson, S. Colloca, N. Brunetti-Pierri, P. Ng, G. Donofrio, and A. Auricchio (2014) Retinal transduction profiles by high-capacity viral vectors. Gene Therapy 21:855-865. 82. Murthy, V., Y. Gao, L. Geng, N.K. LeBrasseur, T.A. White, R.J. Parks, and S. Brimijoin (2014) Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice. Vaccine 32:4155-62. 83. McFall, E.R., L.M. Murray, J.A. Lunde, B.J. Jasmin, R. Kothary, and R.J. Parks (2014) A reduction in the human adenovirus virion size through use of a shortened fibre protein does not enhance muscle transduction following systemic or localized delivery in mice. Virology 468-470:444-453. 84. Saha, B., C.M. Wong, and R.J. Parks (2014) The adenovirus genome contributes to the structural stability of the virion. Viruses 6:3563-3583. 85. Chen, V.P., Y. Gao, L. Geng, R.J. Parks, T. Tchkonia, Y.-P. Pang, S. Brimijoin (2015) Plasma butyrylcholinesterase regulates ghrelin to control aggression PNAS 112:2251-6. 86. Ard, R., K. Mulatz, J.L. Pomoransky, R.J. Parks, L. Trinkle-Mulcahy, J.C. Bell, and S.H. Gee (2015) Regulation of Macropinocytosis by Diacylglycerol Kinase ζ. PLoS ONE 10(12):e0144942. doi: 10.1371/journal.pone.0144942. 87. Wong, C.M., K.L. Poulin, G. Tong, C. Christou, M.A. Kennedy, T. Falls, J.C. Bell and R.J. Parks (2016) Adenovirus-mediated expression of the p14 fusion-associated small transmembrane protein promotes cancer cell fusion and apoptosis in vitro but does not provide therapeutic efficacy in a xenograft mouse model of cancer PLoS ONE 11(3):e0151516. doi: 10.1371/journal.pone.0151516. 88. Al-Khalaf, M., L. Blake, B. Larsen, S. Brunette, R. Parks, M. Rudnicki, P. McKinnon, F. Dilworth, R. Bell and L. Megeney (2016) Temporal activation of XRCC1 mediated DNA repair is essential for muscle differentiation. Cell Discovery 2:15041 doi:10.1038/celldisc.2015.41. 89. Smethells, J.R., N. Swalve, S. Brimijoin, Y. Gao, R.J. Parks, A. Greer, and M.E. Carroll (2016) Long-term blockade of cocaine self-administration and locomotor activation in rats by an adenoviral vector-delivered cocaine hydrolase. J Pharmacol Exp Ther. 2016 Mar 11. pii: jpet.116.232504. 90. Burns, J.K., R. Kothary and R.J. Parks (2016) Opening the window: The case for carrier and perinatal screening for spinal muscular atrophy. Neuromuscular Disorders 26:551-9. 91. Warman Chardon, J., B.J. Jasmin, R. Kothary and Parks, R.J., (2016) Report on the 3rd Ottawa International Conference on Neuromuscular Biology, Disease and Therapy – September 24-26, 2015, Ottawa, Canada. Journal of Neuromuscular Diseases. 3:431–442. 92. Wong, C.M., L.A. Nash, J. Del Papa, K.L. Poulin, T. Falls, J.C. Bell, and R.J. Parks (2016) Expression of the fusogenic p14 FAST protein from a replication-defective adenovirus vector does not provide a therapeutic benefit in an immunocompetent mouse model of cancer. Cancer Gene Therapy 23(10):355-364. 93. Alvarez-Saavedra M., Y. De Repentigny, D. Yang, R.W. O'Meara, K. Yan, L.E. Hashem, L. Racacho, I. Ioshikhes, D.E. Bulman, R.J. Parks, R. Kothary, and D.J. Picketts, (2016) Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice. Cell Rep.11:17(3):862-875. 94. Nash, L.A., J.K. Burns, J. Warman Chardon, R. Kothary and R.J. Parks (2016) Spinal Muscular Atrophy: More than a disease of motor neurons? Current Molecular Medicine (in press).