Bearne, Stephen L. - Dalhousie University

研究领域

Our research focuses on understanding how protein-ligand interactions contribute to rate enhancements in enzymatic reactions, engineering new enzymes, developing tools for identification of specific enzymes in complex proteomes, and understanding the chemical mechanism of enzymes that are of therapeutic interest.

近期论文

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“Structure of Mandelate Racemase with Bound Intermediate Analogues Benzohydroxamate and Cupferron.” A. D. Lietzan, M. Nagar, E. A. Pellmann, J. R. Bourque, J. R., S. L. Bearne, and M. St. Maurice* (Biochemistry, 2012, 51, 1160-1170). “Redefining the Substrate Tolerance of Mandleate Racemase. Racemization of Trifluorolactate.” M. Nagar, A. Narmandakh, Y. Khalak, and Stephen L. Bearne* (Biochemistry, 2011, 50, 8846-8852). “Activation and Inhibition of CTP Synthase from Trypanosoma brucei, the Causative Agent of African Sleeping Sickness.” C. H. Steeves and Stephen L. Bearne* (Bioorg. Med. Chem. Lett., 2011, 21, 5188-5190). “Oxidative Stress Response in the Opportunistic Oral Pathogen Fusobacterium nucleatum.” C. H. Steeves, J. Potrykus, D. A. Barnett, and Stephen L. Bearne* (Proteomics, 2011, 11, 2027-2037). “Inhibition of CTP Synthase from Escherichia coli by Xanthines and Uric Acids.” A. C. Roy, F. A. Lunn, and Stephen L. Bearne* (Bioorg. Med. Chem. Lett., 2010, 20, 141-144).