SHIN, Jumi - University of Toronto - Department of Chemistry

研究领域

Chemistry/Biological and Bioanalytical Chemistry

近期论文

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"The Role of Ligand Density and Size in Mediating Quantum Dot Nuclear Transport." P. Tang, S. Sathiamoorthy, L. Lustig, R. Ponzielli, I. Inamoto, L. Z. Penn, J. A. Shin, & W.C.W. Chan, Small, 2014, 10, 4182-4192. doi: 10.1002/smll.201401056. "Boundaries of the Origin of Replication: Creation of a pET-28a-Derived Vector with p15A Copy Control Allowing Compatible Coexistence with pET Vectors." S. Sathiamoorthy & J. A. Shin, PLoS ONE, 2012, 7, e47259. doi:10.1371/journal.pone.0047259. "The bZIP Dimer Localizes at DNA Full-Sites Where Each Basic Region Can Alternately Translocate and Bind to Subsites at the Half-Site." I. Chan, T. Al-Sarraj, H. S. Shahravan, A. V. Fedorova, & J. A. Shin, Biochemistry, 2012, 51, 6632-6643. "Forced homodimerization of the Fos leucine zipper in designed bHLHZ-like hybrid proteins MaxbHLH-Fos and ArntbHLH-Fos." G. Chen, A. T. De Jong, & J. A. Shin, Molecular BioSystems, 2012, 8, 1286-1296. "Crystal structure of the minimalist Max-E47 protein chimera." F. Ahmadpour, R. Ghirlando, A. T. De Jong, J. A. Shin, & A. Guarne, PLoS ONE, 2012, 7, e32136 (doi:10.1371/journal.pone.0032136). "FRep: a fluorescent protein-based bioprobe for in vivo detection of protein:DNA interactions." S. H. Shahravan, I. T. Li, K. Truong, & J. A. Shin, Analytical Chemistry, 2011, 83, 9643-9650. "Reengineering natural design by rational design and in vivo library selection: the HLH domain in bHLHZ proteins is a unique requirement for DNA-binding function." J. Xu, H.-K. Chow, G. Chen, C. O. Damaso, A. Schwartz Mittelman, & J. A. Shin, Protein Engineering, Design, & Selection, 2010, 23, 337-346. "Max-E47, a designed minimalist protein that targets the E-box DNA site in vivo and in vitro." J. Xu, G. Chen, A. T. De Jong, S. H. Shahravan, & J. A. Shin. Journal of the American Chemical Society, 2009, 131, 7839-7848. "Hybrids of the bHLH and bZIP Protein Motifs Display Different DNA-Binding Activities in vivo vs. in vitro." H.-K. Chow, J. Xu, S. H. Shahravan, A. T. De Jong, G. Chen, & J. A. Shin. PLoS ONE, 2008, 3, e3514. doi:10.1371/journal.pone.0003514. "AhR/Arnt:XRE interaction: turning false negatives into true positives in the modified yeast one-hybrid assay." G. Chen & J. A. Shin. Analytical Biochemistry, 2008, 382, 101-106. "Design of a single plasmid-based modified yeast one-hybrid system for investigation of in vivo protein-protein and protein-DNA interactions." G. Chen, L. M. DenBoer, & J. A. Shin. BioTechniques, 2008, 45, 295-304. "The bZIP targets overlapping DNA sub-sites within a half site resulting in increased binding affinities." I. Chan, S. H. Shahravan, A. V. Fedorova, & J. A. Shin. Biochemistry, 2008, 47, 9646-9652. "Enhancing the specificity of the enterokinase cleavage reaction to promote efficient cleavage of a fusion tag." S. H. Shahravan, X. Qu, I. Chan, & J. A. Shin. Protein Expression and Purification, 2008, 59, 314-319. "The GCN4 bZIP Targets Noncognate Gene Regulatory Sequences: Quantitative Investigation of Binding at Full and Half Sites." I. Chan, A. V. Fedorova, & J. A. Shin. Biochemistry, 2007, 46, 1663-1671. "The GCN4 bZIP Can Bind to Noncognate Gene Regulatory Sequences." A. V. Fedorova, I. Chan, & J. A. Shin. Biochimica et Biophysica Acta (Proteins and Proteomics), 2006, 1764, 1252-1259. "Minimalist Proteins: Design of New Molecular Recognition Scaffolds." J. A. Shin. Pure and Applied Chemistry, 2004, 76, 1579-1590. "Sequence-Specific Recognition of DNA by Hydrophobic, Alanine-scanning Mutants of the bZIP Motif Investigated by Fluorescence Anisotropy." G. H. Bird, A. R. Lajmi, & J. A. Shin. Biopolymers, 2002, 65, 10-20. "MALDI-TOF Mass Spectrometry Characterization of Hydrophobic Basic Region/Leucine Zipper Proteins." G. H. Bird & J. A. Shin. Biochimica et Biophysica Acta (Protein Structure & Molecular Enzymology), 2002, 1597, 252-259. "Manipulation of Temperature to Improve Solubility of Hydrophobic Proteins and Cocrystallization with Matrix for Analysis by MALDI-TOF Mass Spectrometry." G. H. Bird, A. R. Lajmi, & J. A. Shin. Analytical Chemistry, 2002, 74, 219-225. "The Contribution of the Methyl Groups on Thymine Bases to Binding Specificity and Affinity by Alanine-rich Mutants of the bZIP Motif." K. J. Kise Jr. & J. A. Shin. Bioorganic and Medicinal Chemistry, 2001, 9, 2485-2491. "Short, Hydrophobic, Alanine-based Proteins Based on the bZIP Motif: Overcoming Inclusion Body Formation and Protein Aggregation During Overexpression, Purification, and Renaturation." A. R. Lajmi, T. R. Wallace, & J. A. Shin. Protein Expression and Purification, 2000, 18, 394-403. "Minimalist, Alanine-based, Helical Protein Dimers Bind to Specific DNA Sites." A. R. Lajmi, M. E. Lovrencic, T. R. Wallace, R. R. Thomlinson, & J. A. Shin. Journal of the American Chemical Society, 2000, 122, 5638-5639. “Specific DNA Binding Peptide-Derivatized Solid Support.” J. A. Shin. Bioorganic and Medicinal Chemistry Letters, 1997, 7, 2367-2372. "Mechanistic Studies of an Antibody with Chorismate Mutase Activity." J. A. Shin & D. Hilvert. Bioorganic and Medicinal Chemistry Letters, 1994, 4, 2945-2948. "Orientation of the Lac Repressor DNA Binding Domain In Complex with the Left Lac Operator Half Site Characterized by Affinity Cleaving." J. A. Shin, R. H. Ebright, & P. B. Dervan. Nucleic Acids Research, 1991, 19, 5233-5236. "Cooperative Binding of Oligonucleotides to DNA by Triple Helix Formation: Dimerization via Watson-Crick Hydrogen Bonds." M. D. Distefano, J. A. Shin, & P. B. Dervan. Journal of the American Chemical Society, 1991, 113, 5901-5902. "Orientation of the Putative Recognition Helix in the DNA-Binding Domain of Hin Recombinase Complexed with the Hix Site." D. P. Mack, J. P. Sluka, J. A. Shin, J. H. Griffin, M. I. Simon, & P. B. Dervan. Biochemistry, 1990, 29, 6561-6567.