David, Nicewicz - The University of North Carolina at Chapel Hill

个人简介

B.S., University of North Carolina at Charlotte, 2000; M.S., University of North Carolina at Charlotte, 2002; Ph.D., University of North Carolina at Chapel Hill, 2006; NIH Postdoctoral Fellow, Princeton University, 2007-2009; Eli Lilly New Faculty Award, 2009; Packard Fellowship in Science and Engineering, 2012; New Investigator Award in Organic Chemistry, sponsored by Boehringer Ingelheim, 2013; NSF CAREER Award, 2014-2019; Amgen Young Investigator Award, 2014 Education 2006 Ph.D. in Organic Chemistry; University of North Carolina at Chapel Hill 2002 M.S. in Organic Chemistry; University of North Carolina at Charlotte 2000 B.S. Cum Laude in Chemistry; University of North Carolina at Charlotte Professional Experience 2018-present Professor; University of North Carolina at Chapel Hill 2018-present Associate Editor, Synlett 2015-2018 Director of Graduate Studies, Department of Chemistry, University of North Carolina 2015-2018 Associate Professor; University of North Carolina at Chapel Hill 2009-2015 Assistant Professor; University of North Carolina at Chapel Hill 2007-2009 Postdoctoral Research; Princeton University Advisor: Professor David W. C. MacMillan 2001-2006 Graduate Research; University of North Carolina at Chapel Hill Advisor: Professor Jeffrey S. Johnson 2000-2001 Graduate Research; University of North Carolina at Charlotte Advisor: Professor Craig A. Ogle 1999-2000 Undergraduate Research; University of North Carolina at Charlotte Advisor: Professor Craig A. Ogle 1999 Undergraduate Research; University of North Carolina at Charlotte Advisor: Professor Jordan C. Poler

研究领域

Synthetic Organic Chemistry, Catalysis, Natural Product Synthesis My research interests lie in the broadly defined fields of asymmetric catalysis and target-oriented synthesis. Concerning the area of asymmetric catalysis, my laboratory will focus primarily on the development of novel catalytic processes to access highly reactive intermediates under operationally mild conditions. Methods encompassing the general areas of electron transfer and atom abstraction are of particular interest. In the context of natural product synthesis, targets will be selected on the basis of their biological activity and structural complexity. Specifically, I am interested in complex molecules that inspire the development of new strategies and methods for their construction.

近期论文

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McManus, J. B.; Onuska, N. P. R.; Nicewicz, D. A. “Generation and Alkylation of α–Carbamyl Radicals via Organic Photoredox Catalysis.” J. Am. Chem. Soc. 2018, 140, 9056-9060. Morse, P. D.; Nguyen, T. M.; Cruz, C. L.; Nicewicz, D. A. “Enantioselective Counter Anions in Photoredox Catalysis:The Asymmetric Cation Radical Diels-Alder Reaction.” Tetrahedron 2018, 74, 3266-3272. Margrey, K. A.; Czaplyski, W. L.; Nicewicz, D. A.; Alexanian, E. J. “A General Strategy for Aliphatic C–H Functionalization Enabled by Organic Photoredox Catalysis.” J. Am. Chem. Soc. 2018, 140, 4213-4217. Wu, F.; Wang, L.; Chen, J.; Nicewicz, D. A.; Huang, Y. “Direct Synthesis of Polysubstituted Aldehydes via Visible Light-Catalysis.” Angew. Chem. Int. Ed. 2018, 57, 2174-2178. Margrey, K. A.; Levens, A.; Nicewicz, D. A. “Direct C–H Arylation of Primary Amines via Organic Photoredox Catalysis.” Angew. Chem. Int. Ed. 2017, 56, 15644-15648. Tay, N. E.; Nicewicz, D. A. “Cation Radical-Accelerated Nucleophilic Aromatic Substitution via Organic Photoredox Catalysis.” J. Am. Chem. Soc. 2017, 139, 16100-16104. Dongare, P.; MacKenzie, I; Wang, D.; Nicewicz, D. A.; Meyer, T. J. “Oxidation of Alkyl Benzenes by a Flavin Photooxidation Catalyst on Nano-Structured Metal Oxide Films.” Proc. Natl. Acad. Sci. U.S.A. 2017, 114,9279-9283. Margrey, K. A.; McManus, J. B.; Bonazzi, S.; Zecri, F.; Nicewicz, D. A. “Predictive Model for Site-Selective Aryl and Heteroaryl C-H Amination via Organic Photoredox Catalysis.” J. Am. Chem. Soc. 2017, 139, 11288-11299. Wang, L.; Wu, F.; Chen, J.; Nicewicz, D. A.; Huang, Y. “Visible Light-Mediated [4+2] Cycloaddition of Styrenes: Synthesis of Tetralin Derivatives.” Angew. Chem. Int. Ed. 2017, 56, 6896-6900. McManus, J. B.; Nicewicz, D. A. “Direct C–H Cyanation of Arenes via Organic Photoredox Catalysis.” J. Am. Chem. Soc. 2017, 139, 2880-2883. Griffin, J. D.; Cavanaugh, C. L.; Nicewicz, D. A. “Reversing the Regioselectivity of Halofunctionalization Reactions via Cooperative Photoredox and Copper Catalysis.” Angew. Chem. Int. Ed. 2017, 56, 2097-2100. Margrey, K. A.; Nicewicz, D. A. “A General Approach to Catalytic Alkene Anti-Markovnikov Hydrofunctionalization Reactions via Acridinium Photoredox Catalysis.” Acc. Chem. Res. 2016, 49, 1997-2006. (invited contribution). Joshi-Pangu, A.; Lévesque, F.; Roth, H. G.; Oliver, S. F.; Campeau, L.-C.; Nicewicz, D., DiRocco, D. A. “Acridinium-Based Photocatalysts: A Sustainable Option in Photoredox Catalysis.” J. Org. Chem. 2016, 81,7244-7249. Romero, N. A.; Nicewicz, D. A. “Organic Photoredox Catalysis.” Chem. Rev. 2016, 116, 10075-10166 (invited contribution). Roth, H. G.; Romero, N. A.; Nicewicz, D. A. “Experimental and Calculated Electrochemical Potentials of Common Organic Molecules for Applications to Single Electron Redox Chemistry.” Synlett, 2016, 27, 714- 723. Perkowski, A. J.; Cruz, C. L.; Nicewicz, D. A. “An Ambient Temperature Newman-Kwart Rearrangment Mediated by Organic Photoredox Catalysis.” J. Am. Chem. Soc., 2015, 137, 15684-15687. Cavanaugh, C. L.; Nicewicz, D. A. “Synthesis of α-Benzyloxyamino-γ-Butyrolactones via a Polar Radical Crossover Cycloaddition Reaction.” Org. Lett., 2015, 17, 6082-6085. Romero, N. A.; Margrey, K. A.; Tay, N. E.; Nicewicz, D. A.“Site-Selective Arene C–H Amination via Photoredox Catalysis.” Science, 2015, 349, 1326-1330. Griffin, J. D.; Zeller, M. A.; Nicewicz, D. A.”Hydrodecarboxylation of Carboxylic and Malonic Acid Derivatives via Organic Photoredox Catalysis: Substrate Scope and Mechanistic Insight.” J. Am. Chem. Soc. 2015, 137, 11340-11348. Perkowski, A. J.; You, W.; Nicewicz, D. A. “Visibile Light Photoinitiated Metal-Free Living Cationic Polymerization of 4-Methoxystyrene.” J. Am. Chem. Soc. 2015, 137, 7580-7583.