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Wei Jiang,+ Sami Abdulkadir,+ Xue Zhao,+ Peng Sang, Anastasia Tomatsidou, Xiujun Zhang, Yu Chen, Laurent Calcul, Xingmin Sun, Feng Cheng,* Yong Hu,* Jianfeng Cai.* Inhibition of Hypoxia-Inducible Transcription Factor (HIF-1α) Signaling with Sulfonyl-γ-AApeptide Helices. J. Am. Chem. Soc. ASAP.
Songyi Xue,+ Wei Xu,+* Lei Wang, Ling Xu, Laurent Calcul, Peng Teng, Lu Lu, Shibo Jiang,* and Jianfeng Cai.* Rational Design of Sulfonyl-γ-AApeptides as Highly Potent HIV-1 Fusion Inhibitors with Broad-spectrum Activity. J. Med. Chem. ASAP.
Ali Azmy,+ Xue Zhao,+ Giasemi K. Angeli, Claire Welton, Parth Raval, Lukasz Wojtas, Nourdine Zibouche, G. N. Manjunatha Reddy, Pantelis N. Trikalitis, Jianfeng Cai, and Ioannis Spanopoulos.* One Year Water Stable and Porous Bi(III) Halide Semiconductor with Broad Spectrum Antibacterial Performance. ACS App. Mater. Inter. ASAP.
Peng Sang,* Jianfeng Cai.* Unnatural Helical Peptidic Foldamers as Protein Segment Mimics. Chem. Soc. Rev. 2023, 52, 4843-4877.
Seid Yimer Abate,+ Ziqi Yang,+ Surabhi Jha, Jada Emodogo, Guorong Ma, Zhongliang Ouyang, Shafi Muhammad, Nihar Pradhan, Xiaodan Gu, Derek Patton, Dawen Li, Jianfeng Cai,* and Qilin Dai.* Promoting large area slot-die coated perovskite solar cells performance and reproducibility by acid-based sulfono-γ-AApeptide. ACS Appl. Mater. Inter. 2023, 15, 21, 25495–25505.
Hongtao Kong,+ Shangshang Qin,+ Dachao Yan, Boyuan Shen, Tingting Zhang, Meng Wang, Sen Li, Maxwell Ampomah-Wireko, Mengmeng Bai, En Zhang,* Jianfeng Cai.* Development of aromatic-linked diamino acid antimicrobial peptide mimics with low hemolytic toxicity and excellent activity against methicillin-resistant Staphylococcus aureus (MRSA). J. Med. Chem. 2023, accepted.
Songyi Xue,+ Wei Xu,+* Lei Wang, Xinling Wang, Qianyu Duan, Laurent Calcul, Shaohui Wang, Wenqi Liu, Xingmin Sun, Lu Lu,* Shibo Jiang,*, and Jianfeng Cai.* An HR2-mimicking sulfonyl-γ-AApeptide is a potent pan-coronavirus fusion inhibitor with strong blood-brain barrier permeability, long half-life and promising oral bioavailability. ACS Central. Sci. 2023, accepted. Link
Diego Alem, Xinrui Yang, Francisca Beato, Bhaswati Sarcar, Alexandra F. Tassielli, Ruifan Dai, Tara L. Hogenson, Margaret A. Park, Kun Jiang, Jianfeng Cai, Yu Yuan, Martin E. Fernandez-Zapico, Aik Choon Tan, Jason B. Fleming, Hao Xie.* Translational relevance of SOS1 targeting for KRASâ€mutant colorectal cancer. Mol. Carcinogenesis, 2023, Accepted. Link
Yafeng Wang, Menglin Xue, Ruixuan Gao, Soumyadeep Chakraborty, Shaohui Wang, Xue Zhao, Meng Gu, Chuanhai Cao, Xinmin Sun, Jianfeng Cai.* Short lipidated dendrimeric γ-AApeptides as new antimicrobial peptidomimetics. Int. J. Mol. Sci., 2023, 24, 7, 6407. Link
Lei Wang,+ Chunlong Ma,+ Michael Dominic Sacco,+ Songyi Xue, Mentalla Mahmoud, Laurent Calcul, Yu Chen,* Jun Wang,* and Jianfeng Cai.* Development of the Safe and Broad-Spectrum Aldehyde and Ketoamide Mpro inhibitors Derived from the Constrained α, γ-AA Peptide Scaffold. Chem. Eur. J. 2023, ASAP. Link
Meng Gu,+ Ying Yu,+ Menglin Xue, Jianxiong Jiang,* Jianfeng Cai.* The discovery of cyclic γ-AApeptides as the promising ligands targeting EP2. Bioorg. Med. Chem. Lett. 2023, 87, 129255. Link
Peng Teng,* Haodong Shao, Bo Huang, Junqiu Xie, Sunliang Cui,* Kairong Wang,* Jianfeng Cai.* Small Molecular Mimetics of Antimicrobial Peptides as a Promising Therapy to Combat Bacterial Resistance. J. Med. Chem. 2023, 66, 4, 2211–2234. Link
Oksana Fihurka, Yanhong Wang, Yuzhu Hong, Xiaoyang Lin, Ning Shen, Haiqiang Yang, Breanna Brown, Marcus Mommer, Tarek Zieneldien, Yitong Li, Janice Kim, Minghua Li, Jianfeng Cai, Qingyu Zhou,* Chuanhai Cao.* Multi-targeting intranasal nanoformulation as a therapeutic for Alzheimer's disease. Biomolecules, 2023, 13, 232. Link
Ruixuan Gao, Xuming Li, Menglin Xue, Ning Shen, Minghui Wang, Jingyao Zhang, Chuanhai Cao, and Jianfeng Cai.* Development of Lipidated Polycarbonates with Broad-Spectrum Antimicrobial Activity. Biomater. Sci. 2023, 11, 1840-1852. Link
Xiaoqian Feng, Dongyi Xiana, Jintao Fu, Rui Luo, Wenhao Wang, Yuwei Zheng, Qing He, Zhan Ouyang, Shaobin Fang, Wancong Zhang, Daojun Liu, Shijie Tang, Guilan Quan, Jianfeng Cai, Chuanbin Wu, Chao Lu,* Xin Pan.* Four-armed host-defense peptidomimetics-augmented vanadium carbide MXene-based microneedle array for efficient photo-excited bacteria-killing. Chem. Eng. J. 2023, 456, 141121. Link
Rekha S. Patel, Ashley Lui, Charles Hudson, Lauren Moss, Robert Sparks, Shannon E. Hill, Yan Shi, Jianfeng Cai, Laura J. Blair, Paula Bickford, Niketa A. Patel.* Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model. Sci. Rep. 2023, 13, 373. Link
Seid Yimer Abate,+ Ziqi Yang,+ Surabhi Jha, Guorong Ma, Zhongliang Ouyang, Haixin Zhang, Shafi Muhammad, Nihar Pradhan, Xiaodan Gu, Derek Patton, Kun Wang, Dawen Li, Jianfeng Cai,* Qilin Dai.* Room Temperature Slot-Die Coated Perovskite Layer Modified with sulfonyl-γ-AApeptide for High Performance Perovskite Solar Devices. Chem. Eng. J. 2023, 457, 141199. Link
Li Zhou,+ In Ho Jeong,+ Songyi Xue, Menglin Xue, Lei Wang, Sihao Li, Ruochuan Liu, Geon Ho Jeong, Xiaoyu Wang, Jianfeng Cai,* Jun Yin,* Bo Huang.* Inhibition of the ubiquitin transfer cascade by peptidomimetic foldamer mimicking E2 N-terminal-helix. J. Med. Chem. 2023, 66, 1, 491–502. Link
Xueying Ge, Fangchao Jiang, Minghui Wang, Meng Chen, Yiming Li, Joshua Phipps, Jianfeng Cai, Jin Xie, Jane Ong, Viktor Dubovoy, James G. Masters, Long Pan,* Shengqian Ma.* Naringin@Metal-Organic Framework as a Multifunctional Bio-platform. ACS Applied Mater. Interface. 2023, 15, 1, 677–683. Link
Pengcheng Li, Xiaohuan Chen, Cui Guo, Huijing Zou, Ziyi Chen, Bingjie Liu, Wenjie Liang,* Jianfeng Cai,* Hai Xu.* A Logic Fluorescent Chemosensor Based on Eu3+ Functionalized Cd-MOFs for Sensing Fe3+ and Cu2+ Synchronously. Eur. J. Inorg. Chem. 2023, ASAP. Link
Xiaomin Guo, Tiantian Yan, Jing Rao, Yingying An, Xin Yue, Xiaokang Miao, Rui Wang, Wangsheng Sun,* Jianfeng Cai,* and Junqiu Xie.* Novel Feleucin-K3-derived peptides modified with sulfono-γ-AA building blocks targeting Pseudomonas aeruginosa and MRSA infections. J. Med. Chem. 2023, 66, 2, 1254-1272. Link
Yan Shi,+ Candy Lee,+ Peng Sang, Zaid Amso, David Huang, Weixia Zhong, Meng Gu, Lulu Wei, Vân T. B. Nguyen-Tran, Jingyao Zhang, Weijun Shen,* Jianfeng Cai.* α/Sulfono-γ-AA peptide hybrids agonist of GLP-1R with prolonged action both in vitro and in vivo. Acta Pharmaceutica Sinica B, 2023, 1648-1659. Link
Yujia Bian, Diego Alem, Francisca Beato, Tara L. Hogenson, Xinrui Yang, Kun Jiang, Jianfeng Cai, Wen Wee Ma, Martin Fernandez-Zapico, Aik Choon Tan, Nicholas J. Lawrence, Jason B. Fleming, Yu Yuan*, Hao Xie.* Development of SOS1 inhibitor-based degraders to target KRAS-mutant colorectal cancer. J. Med. Chem. 2022, 65, 24, 16432–16450. Link
Songyi Xue,+ Xinling Wang,+ Lei Wang, Wei Xu, Shuai Xia, Lujia Sun, Shaohui Wang, Ning Shen, Ziqi Yang, Bo Huang, Sihao Li, Chuanhai Cao, Laurent Calcul, Xingmin Sun, Lu Lu,* Jianfeng Cai,* and Shibo Jiang.* A novel cyclic γ-AApeptide-based long-acting pan-coronavirus fusion inhibitor with potential oral bioavailability by targeting two sites in spike protein. Cell. Dis. 2022, 8, 88. Link
Jie Zhong, Yuegui Guo, Shaoyong Lu, Kun Song, Ying Wang, Li Feng, Zhen Zheng, Qiufen Zhang, Jiacheng Wei, Peng Sang, Yan Shi, Jianfeng Cai, Guoqiang Chen, Chen-Ying Liu,* Xiuyan Yang,* and Jian Zhang.* Rational design of a sensitivity-enhanced tracer for discovering efficient APC-Asef inhibitors .Nat. Commun. 2022, 13(1):4961. Link
Songyi Xue,+ Lei Wang,+ Jianfeng Cai.* Sulfono-γ-AApeptides as protein helical domain mimetics to manipulate the angiogenesis.ChemBioChem 2022, 23, e202200298. Link
Xing Zhang,+ Minghui Wang,+ Xiaodi Zhu, Yan Peng, Tiwei Fu, Chang-Hua Hu, Jianfeng Cai,* Guojian Liao.* Development of lipo-γ-AA peptides as potent antifungal agents.J. Med. Chem. 2022, 65, 11, 8029–8039. Link
Feng Li,+ Liming Lin,+ Jiaying Chi, Hui Wang, Minqun Du, Disang Feng, Liqing Wang, Rui Luo, Hangping Chen, Guilan Quan, Jianfeng Cai, Xin Pan, Chuanbin Wu, Chao Lu.* Guanidinium-Rich Lipopeptide Functionalized Bacteria-Absorbing Sponge as an Effective Trap-and-Kill System for the Elimination of Focal Bacterial Infection.Acta Biomaterialia 2022, 148, 106-118. Link
Peng Sang, Yan Shi, Lulu Wei, and Jianfeng Cai.* Helical Sulfono-γ-AApeptides with Predictable Functions in Protein Recognition. RSC Chem. Biol. 2022, 3, 805. Link
Yanhong Wang, Yuzhu Hong, Jiyu Yan, Breanna Brown, Xiaoyang Lin, Xiaolin Zhang, Ning Shen, Minghua Li, Jianfeng Cai, Marcia Gordon, David Morgan, Qingyu Zhou,* and Chuanhai Cao.* Low-Dose Delta-9-Tetrahydrocannabinol as Beneficial Treatment for Aged APP/PS1 Mice. Int. J. Mol. Sci. 2022. 23, 5, 2757. Link
Wei Jiang,+ Lulu Wei,+ Bing Chen, Xingyu Luo, Peipei Xu, Jianfeng Cai, and Yong Hu.* Platinum Prodrug Nanoparticles Inhibiting Tumor Recurrence and Metastasis by Concurrent Chemoradiotherapy. J. Nano. Biotechnol. 2022. 20:129. Link
Jintao Fu,Ting Liu, Xiaoqian Feng, Yixian Zhou, Minglong Chen, Wenhao Wang, Yiting Zhao, Chao Lu, Guilan Quan, Jianfeng Cai, Xin Pan*, Chuanbin Wu. Perfect Pair: Stabilized Black Phosphorous Nanosheets Engineering with Antimicrobial Peptides for Robust Multi-Drug Resistant Bacteria Eradication. Adv Healthc Mater. 2022. e2101846. Link
Peng Teng* and Jianfeng Cai.* Using Proteomimetics to Switch Angiogenic Signaling. Acta Pharmaceutica Sinica B 2022. 1534-1535. Link
Bo Huang,+ Li Zhou,+ Ruochuan Liu,+ Lei Wang, Songyi Xue, Yan Shi, Geon Ho Jeong, In Ho Jeong, Sihao Li, Jun Yin,* Jianfeng Cai.* Activation of E6AP/UBE3A-Mediated Protein Ubiquitination and Degradation Pathways by a Cyclic Gamma-AApeptide. J. Med. Chem. 2022, 65, 2497-2506. Link
Sami Abdulkadir,+ Chunpu Li,+ Wei Jiang,+ Xue Zhao, Peng Sang, Lulu Wei, Yong Hu,* Qi Li,* and Jianfeng Cai.* Modulating Angiogenesis by Proteomimetics of Vascular Endothelial Growth Factor. J. Am. Chem. Soc., 2022, 144, 1, 270–281. Link
Lulu Wei and Jianfeng Cai.* Novel Peptides and Peptidomimetics in Drug Discovery. Acta Pharmaceutica Sinica B, 2021, 2606-2608. Link
Maochao Zheng, Huanchang Lina, Wancong Zhang, Shijie Tang,* Daojun Liu,* and Jianfeng Cai.* Poly(L-ornithine)-grafted zinc phthalocyanines as dual-functional antimicrobial agents with intrinsic membrane damage and photothermal ablation capacity. ACS Infect. Dis. 2021, 7, 10, 2917–2929. Link
Peng Sang,+ Hongxiang Zeng,+ Candy Lee,+ Yan Shi, Minghui Wang, Cong Pan, Lulu Wei, Chenglong Huang, Mingjun Wu, Weijun Shen,* Xi Li,* and Jianfeng Cai.* α/sulfono-γ-AApeptide Hybrid Analogues of Glucagon with Enhanced Stability and Prolonged in vivo Activity. J. Med. Chem. 2021, 64, 18, 13893–13901. Link
Mengmeng Zheng,+ Chunpu Li,+ Mi Zhou,+ Ru Jia, Gang Cai, Fengyu She, Lulu Wei, Shaohui Wang, Jie Yu, Dingyan Wang, Laurent Calcul, Xingmin Sun, Xiaomin Luo, Feng Cheng, Qi Li,* Yan Wang,* and Jianfeng Cai.* Discovery of Cyclic Peptidomimetic Ligands Targeting the Extracellular Domain of EGFR. J. Med. Chem. 2021, 64, 15, 11219-11228. Link
Wei Jiang, Xingyu Luo, Lulu Wei, Shanmei Yuan, Jianfeng Cai,* Xiqun Jiang,* and Yong Hu.* The Sustainability of Energy Conversion Inhibition for Tumor Ferroptosis Therapy and Chemotherapy. Small, 2021, 17, 38, 2102695. Link
Mengmeng Zheng,+ Chunpu Li,+ Mi Zhou,+ Ru Jia, Fengyu She, Lulu Wei, Feng Cheng, Qi Li, * Jianfeng Cai* and Yan Wang.* Peptidomimetic-based antibody surrogate for HER2. Acta Pharmaceutica Sinica B, 2021, 2645-2654. Link
Yingru Zhang,+ Chunpu Li,+ Ru Jia,+ Ruixuan Gao, Yiyang Zhao, Qing Ji, Jianfeng Cai,* Qi Li,* and Yan Wang.* PEG-poly(amino acid)s/EpCAM aptamer multifunctional nanoparticles arrest the growth and metastasis of colorectal cancer. Biomater. Sci. 2021, 9, 3705-3717.Link
Song Qing, Han Zhifen, Xinnan Wu, Yan Wang, Lihong Zhou, Liu Yang, Ningning Liu, Hua Sui, Jianfeng Cai, Qing Ji,* Li Qi.* β-arrestin1 promotes colorectal cancer metastasis through GSK-3β/β-catenin signaling-mediated epithelial-to-mesenchymal transition. Frontiers Cell Develop. Biol. 2021, 9, 650067. Link
Yan Shi, Peng Sang and Jianfeng Cai.*. Discovery of α‑Helix-Mimicking Sulfono-γ-AApeptides as p53−MDM2 inhibitors. Future. Med. Chem. 2021, 12, 1021-1023. Link
Minghui Wang,+ Xiaoqian Feng,+ Ruixuan Gao, Peng Sang, Xin Pan, Lulu Wei, Chao Lu,* Chuanbin Wu,* Jianfeng Cai.* Modular Design of Membrane Active Antibiotics: From Macromolecular Antimicrobials to Small Scorpion-like Peptidomimetics. J. Med. Chem. 2021, 64, 14, 9894-9905. Link
Peng Teng,*,+ Mengmeng Zheng,+ Darrell Cole Cerrato, Yan Shi, Mi Zhou, Songyi Xue, Wei Jiang, Lukasz Wojtas, Li-June Ming, Yong Hu,* Jianfeng Cai.* The Folding Propensity of α/Sulfono-γ-AA Peptidic Foldamers with Both Left- and Right-Handedness. Commun. Chem. 2021, 58, 4. Link
Lulu Wei,+ Ruixuan Gao,+ Minghui Wang,+ Yafeng Wang, Yan Shi, Meng Gu and Jianfeng Cai.* Dimeric Lipo-α/sulfono-γ-AA Hybrid Peptides as Broad-Spectrum Antibiotic Agents. Biomater. Sci. 2021, 9, 3410–3424. Link
Yin Shi, Xiaoqian Feng, Jing Wang, Limin Lin, Biyuan Wu, Guilin Zhou, Feiyuan Yu, Qian Xu, Daojun Liu, Guilan Quan, Chao Lu,* Xin Pan,* Jianfeng Cai,* Chuanbin Wu.* Virus-Inspired Surface-Nanoengineered Antimicrobial Liposome: A potential System to Simultaneously Achieve High Activity and Selectivity. Bioactive Mat. 2021, 6, 3207-3217. Link
Maochao Zheng, Miao Pan, Wancong Zhang, Huanchang Lin,Shenlang Wu, Chao Lu,* Shijie Tang,* Daojun Liu,* Jianfeng Cai.* Poly(α-L-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives. Bioactive Mat. 2021, 6, 1878-1909. Link
Jianfeng Cai* and Ruihui Liu.* Introduction to Antibacterial Biomaterials. Biomater. Sci. 2020, 8, 6812-6813. Link
Qing Song, Liu Yang, Zhifen Han, Xinnan Wu, Ruixiao Li, Lihong Zhou, Ningning Liu, Hua Sui, Jianfeng Cai, Yan Wang, Qing Ji,* and Qi Li.* Tanshinone IIA Inhibits Epithelial-to-Mesenchymal Transition Through Hindering β-Arrestin1 Mediated β-Catenin Signaling Pathway in Colorectal Cancer. Front. Pharmacol. 2020, 11, 586616. Link
Yan Shi,+ Peng Sang,+ Junhao Lu,+ Pirada Higbee,+ Lihong Chen, Leixiang Yang, Timothy Odom, Gary Daughdrill,* Jiandong Chen,* and Jianfeng Cai.* Rational Design of Right-Handed Heterogeneous Peptidomimetics as Inhibitors of Protein−Protein Interactions. J. Med. Chem. 2020, 63, 21, 13187–13196. Link
Minghui Wang, Ruixuan Gao, Mengmeng Zheng, Peng Sang, Chunpu Li, En Zhang, Qi Li, and Jianfeng Cai.* Development of Bis-Cyclic Imidazolidine-4-one Derivatives as Potent Antibacterial Agents. J. Med. Chem. 2020, 63, 24, 15591-15602. Link Cover
Peng Sang,+ Yan Shi,+ Bo Huang, Songyi Xue, Timothy Odom, and Jianfeng Cai.* Sulfono-γ-AApeptides as helical mimetics: Crystal structures and applications. Acc. Chem. Res. 2020, 53, 10, 2425–2442. Link
Runzhe Song, Yue Wang, Minghui Wang, Ruixuan Gao, Teng Yang, Song Yang, Cai-Guang Yang, Yongsheng Jin, Siyuan Zou, Jianfeng Cai,* Renhua Fan,* Qiuqin He.* Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity. Bioorg. Chem. 2020, 104176. Link
Miao Pan,+ Chao Lu, Maochao Zheng, Wen Zhou, Fuling Song, Weidong Chen, Fen Yao, Daojun Liu,* and Jianfeng Cai.* Unnatural Amino Acid-Based Star-Shaped Poly(L-ornithine)s as Emerging Long-Term and Biofilm-Disrupting Antimicrobial Peptides to Treat Pseudomonas aeruginosa Infected Burn Wounds. Adv. Healthcare. Mat., 2020, 9, 19, 2000647. Link
Ge Song, Haiqiang Yang, Ning Shen, Phillip Pham, Breanna Brown, Xiaoyang Lin,Yuzhu Hong, Paul Sinu, Jianfeng Cai, Xiaopeng Li, Michael Leon, Marcia Gordon, David Morgan, Sai Zhang, and Chuanhai Cao.* An Immunomodulatory Therapeutic Vaccine Targeting Oligomeric Amyloid Beta. J. Alz. Dis., 2020, 77, 4, 1639-1653. Link
Peng Sang,+ Yan Shi,+ Pirada Higbee,+ Minghui Wang, Sami Abdulkadir, Junhao Lu, Gary W. Daughdrill,* Jiandong Chen,* and Jianfeng Cai.* Rational Design and Synthesis of Right-Handed D-Sulfono-γ-AApeptide Helical Foldamers as Potent Inhibitors of Protein-Protein Interactions. J. Org. Chem. 2020, 85, 10552-10560. Link
Chengming Fu, Tian Chen, Tile Xiao, Yuecai Song, Timothy Odom, Wenjie Liang,* Jianfeng Cai,* Hai Xu.* Formaldehyde Gas Adsorption in Highâ€Capacity Silverâ€Nanoparticleâ€Loaded ZIFâ€8 and UiOâ€66 Frameworks. ChemistrySelect, 2020, 5987-5992. Link
Hao Liu, Shijie Yi, Yunfeng Wu, Han Wu, Jinrong Zhou, Wenjie Liang,* Jianfeng Cai,* and Hai Xu.* An efficient Co-N/C electrocatalyst for oxygen reduction facilely prepared by tuning cobalt species content. Int. J. Hydro. Energy 2020, 16105-16113. Link
Minghui Wang, Ruixuan Gao, Peng Sang, Tomothy Odom, Mengmeng Zheng, Yan Shi, Hai Xu, Chuanhai Cao and Jianfeng Cai.* Dimeric γ-AApeptides with Potent and Selective Antibacterial Activity. Front. Chem. 2020, 8, 441. Link
Jing Wang,+ Chao Lu,+ Yin Shi, Xiaoqian Feng, Biyuan Wu, Guilin Zhou, Guilan Quan, Xin Pan,* Jianfeng Cai,* and Chuanbin Wu.* Structural Superiority of Guanidinium-Rich Four-Armed Copolypeptides: Role of Multiple Peptide-Membrane Interactions in Enhancing Bacterial Membrane Perturbation and Permeability. ACS. Appl. Mater. Inter. 2020, 12, 16, 18363-18374. Link
Yan Shi,+ Peng Sang,+ Guangqiang Yin, Ruixuan Gao Xiao Liang, Robert Brzozowski, Prahathees Eswara, Timothy Odom, Youxuan Zheng,* Xiaopeng Li,* and Jianfeng Cai.* Aggregation-Induced Emissive and Circularly Polarized Homogeneous Sulfono-γ-AApeptide Foldamers. Adv. Opt. Mater. 2020, 8, 1902122. Link
Peng Sang,+ Zhihong Zhou,+ Yan Shi, Candy Lee, Zaid Amso, David Huang, Timothy Odom, Vân T.B. Nguyen-Tran, Weijun Shen,* and Jianfeng Cai.* The Activity of Sulfono-γ-AApeptide Helical Foldamers That Mimic GLP-1. Sci. Adv. 2020, 6, 20, eaaz4988. Link
Minghui Wang, Timothy Odom, and Jianfeng Cai.* Challenges in the development of next-generation antibiotics: Opportunities of small molecules mimicking mode of action of host-defense peptides. Exp. Opin. Ther. Pat. 2020, 303-305, Link
De-Yun Cui, Hong-Tao Kong, Yi Yang, Jianfeng Cai, Bo-Yuan Shen, Da-chao Yan, Xiu-Juan Zhang, Ying-Long Qu, Meng-Meng Bai, En Zhang.* Asymmetric synthesis of linezolid thiazolidine-2-thione derivatives via CS2 mediated decarboxylation cyclization. Tetrahedron lett. 2020, 151847, Link.
Qing Ji, Lihong Zhou, Hua Sui, Liu Yang, Xinnan Wu, Qing Song, Ru Jia, Ruixiao Li, Jian Sun, Ziyuan Wang, Ningning Liu, Yuanyuan Feng, Xiaoting Sun, Gang Cai, Yu Feng, Jianfeng Cai, Yihai Cao, Guoxiang Cai, yan wang, and Qi Li.* Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation. Nat. Commun. 2020, 11, 1211. Link
Peng Sang,+ Yan Shi,+ Junhao Lu,+ Lihong Chen, Leixiang Yang, Wade Borcherds, Sami Abdulkadir, Qi Li,* Gary Daughdrill,* Jiandong Chen,* and Jianfeng Cai.* α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53-MDM2/MDMX Protein–Protein Interactions. J. Med. Chem. 2020, 63, 3, 975-986. Link Cover
Mi Zhou,+ Mengmeng Zheng,+ and Jianfeng Cai.* Small molecules with membrane-active antibacterial activity. ACS. Appl. Mater. Inter. 2020, 12, 19, 21292-21299 Link
Olapeju Bolarinwa, Chunpu Li, Nawal Khadka, Qi Li, Yan Wang, Jianjun Pan,* and Jianfeng Cai.* γ-AApeptides–based Small Molecule Ligands That Disaggregate Human Islet Amyloid Polypeptide. Sci. Rep., 2020, 10, 95. Link
Sylvia Singh, Minghui Wang, Ruixuan Gao, Peng Teng, Timothy Odom, En Zhang, Hai Xu, and Jianfeng Cai.* Lipidated α/Sulfono-α-AA heterogeneous peptides as antimicrobial agents for MRSA. Bioorg. Med. Chem., 2020, 28, 115241. Link
Lulu Wei, Minghui Wang, Ruixuan Gao, Rojin Fatirkhorani and Jianfeng Cai.* Antibacterial activity of lipo-α/sulfono-γ-AA hybrid peptides. Eur. J. Med. Chem., 2020, 186, 11901. Link
Ma Su, Yan Shi, Minghui Wang, Ruixuan Gao, Jianfeng Wu, Hai Xu, Chuanwu Xi,* and Jianfeng Cai.* The Activity of Small Ureaâ€Î³â€AApeptides Toward Gramâ€Positive Bacteria. ChemMedChem,, 2019, 14, 1963-1967. Link
Ma Su, Minghui Wang, Yuzhu Hong, Alekhya Nimmagadda, Ning Shen, Yan Shi, Ruixuan Gao, En Zhang, Chuanhai Cao,* and Jianfeng Cai.* Polymyxin Derivatives as Broad-Spectrum Antibiotic Agents. Chem. Commun., 2019, 55, 13104-13107. Link
Wei Jiang, Chao Zhang, Arsalan Ahmed, Yunlei Zhao, Yu Deng, Yin Ding,* Jianfeng Cai,* and Yong Hu.* H2O2-Sensitive Upconversion Nanocluster Bomb for Tri-Mode Imaging-Guided Photodynamic Therapy in Deep Tumor Tissue. Adv. Healthcare Mat., 2019, 1900972. Link
Chao Lu, Guilan Quan, Ma Su, Alekhya Nimmagadda, Weidong Chen, Miao Pan, Peng Teng, Feiyuan Yu, Xi Liu, Ling Jiang, Wenyi Du, Wei Hu, Fen Yao, Xin Pan, Chuanbin Wu,* Daojun Liu,* and Jianfeng Cai.* Molecular Architecture and Charging Effects Enhance the in Vitro and in Vivo Performance of Multi-Arm Antimicrobial Agents Based on Star-Shaped Poly(L-lysine). Advanced Therapeutics, 2019, 1900147. Link Cover
Heng Wang,+ Chung-Hao Liu,+ Kun Wang, Minghui Wang, Hao Yu, Sneha Kandapal, Robert Brzozowski, Bingqian Xu, Ming Wang, Shuai Lu, Xin-Qi Hao, Prahathees Eswara, Mu-Ping Nieh,* Jianfeng Cai,* and Xiaopeng Li.* Assembling Pentatopic Terpyridine Ligand with Three Types of Coordination Moieties into Giant Supramolecular Hexagonal Prism: Synthesis, Self-Assembly, Characterization, and Antimicrobial Study. J. Am. Chem. Soc., 2019, 16108-16116. Link
Yong Liang, Xiang Wang, Siqi Zhao, Piao He, Ting Luo, Jinzhi Jiang, Wenjie Liang,* Jianfeng Cai,* and Hai Xu.* A New Photoresponsive Bis (Crown Ether) for Extraction of Metal Ions. ChemistrySelect, 2019, 4, 10316-10319. Link
Yan Shi,+ Guangqiang Yin,+ Zhiping Yan, Peng Sang, Minghui Wang, Robert Brzozowski, Prahathees Eswara, Lukasz Wojtas, Youxuan Zheng,* Xiaopeng Li,* and Jianfeng Cai.* Helical Sulfono-γ-AApeptides with Aggregation-Induced Emission and Circularly Polarized Luminescence. J. Am. Chem. Soc., 2019, 141, 12697-12706. Link
Wenchao Chu, Yi Yang, Jianfeng Cai, Hongtao Kong, Mengmeng Bai, Xiangjing Fu, Shangshang Qin, En Zhang.* Synthesis and Bioactivities of New Membrane-active Agents with Aromatic Linker: High Selectivity and Broad-Spectrum Antibacterial Activity. ACS. Infect. Dis., 2019, 13, 5, 1535-1545. Link
Yan Shi, Niketa A. Patel and Jianfeng Cai.* Discovery of a Macrocyclic γ AApeptide binding to lncRNA GAS5 and its therapeutic implication in Type 2 Diabetes. Future. Med. Chem., 2019, 11, 2233-2235. Link
Chunpu Li,+ Gang Cai,+ Daqian Song,+ Ruixuan Gao, Peng Teng, LiHong Zhou, Qing Ji, Hua Sui, Jianfeng Cai,* Qi Li,* and Yan Wang.* Development of EGFR-targeted Evodiamine-loaded poly(amino acid)s nanoparticles for the treatment of colorectal cancer. Biomat. Sci., 2019, 2019,7, 3627-3639. Link
Simon S. Terzyan, Tao Shen, Xuan Liu, Qingling Huang, Peng Teng, Mi Zhou, Frank Hilberg, Jianfeng Cai, Blaine H.M. Mooers, and Jie Wu.* Structural basis of resistance of mutant RET protein tyrosine kinase to its inhibitors nintedanib and vandetanib. J. Biol. Chem., 2019, 294, 27, 10428-10437.Link.
Ning Shen, Ge Song, Haiqiang Yang, Xiaoyang Lin, Breanna Brown, Yuzhu Hong, Jianfeng Cai, Chuanhai Cao.* Identifying the pathological domain of alpha- synuclein as a therapeutic for Parkinson’s disease. Int. J. Mol. Sci., 2019, 20, 2338. Link
Peng Sang,+ Min Zhang,+ Yan Shi,+ Chunpu Li, Sami Abdulkadir, Qi Li,* Haitao Ji,* and Jianfeng Cai.* Inhibition of β−Catenin/ B-Cell Lymphoma 9 Protein−Protein Interaction Using α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors. Proc. Natl. Acad. Sci. U. S. A., 2019, 116, 10757-10762. Link. Access the recommendation on F1000Prime
Peng Teng, Geoffrey M. Gray, Mengmeng Zheng, Sylvia Singh, Xiaopeng Li, Lukasz Wojtas, Arjan van der Vaart, and Jianfeng Cai.* Orthogonal Halogen Bonding Driven 3D Supramolecular Assembly of Right-Handed Synthetic Helical Peptides. Angew. Chem. Int. Ed., 2019, 58, 7778-7782. Link
Qing Yin, Tao Han, Bin Fang, Guolin Zhang, Chao Zhang, Evan R. Roberts, Victoria Izumi, Mengmeng Zheng, Shulong Jiang, Xiu Yin, Minjung Kim, Jianfeng Cai, Eric B. Haura, John M. Koomen, Keiran S. M. Smalley and Lixin Wan.* K27-linked Ubiquitination of BRAF by ITCH Engages Cytokine Response to Maintain MEK-ERK Signaling. Nat. Commun., 2019, 10, 1870. Link
Chu Wenchao,+ Yi Yang,+ Shangshang Qin,+ Jianfeng Cai, Mengmeng Bai, Kong Hongtao and En Zhang.* Low-toxicity Amphiphilic Molecules linked by an Aromatic Nucleus Show Broad-spectrum Antibacterial Activity and Low Drug Resistance. Chem. Commun., 2019, 55, 4307-4310. Link
Hao Yan,+ Mi Zhou,+ Umesh Bhattarai, Yabin Song, Mengmeng Zheng, Jianfeng Cai,* Fu-Sen Liang.* Cyclic peptidomimetics as inhibitors for miR-155 biogenesis. Mol. Pharm., 2019, 16, 914-920. Link
Zhong Peng, Shaohui Wang, Mussie Gide, Duolong Zhu, Chunhui Li, Jianfeng Cai, Xingmin Sun.* A novel bacteriophage lysin-human defensin fusion protein is effective in treatment of Clostridioides difficile infection in mice. Frontiers in Microbiology, 2019, 9, 3234. Link
Ting Luo, Hao Liu, Yong Liang, Jun Tang, Jinrong Zhou, Wenjie Liang,* Jianfeng Cai,* and Hai Xu.* A Comparison of Drug Delivery Systems of Zrâ€Based MOFs and Halloysite Nanotubes: Evaluation of βâ€Estradiol Encapsulation. ChemistrySelect, 2019, 4, 8925-8929. Link
Yan Shi,+ Sajan Parag,+ Rekha Patel, Ashley Lui, Michel Murr, Jianfeng Cai*, and Niketa A. Patel*. Stabilization of lncRNA GAS5 by a small molecule and its implications in diabetic adipocytes, Cell. Chem. Biol., 2019, 26, 319-330. Link Comments
Alekhya Nimmagadda, Yan Shi and Jianfeng Cai.* γ-AApeptides as a new strategy for therapeutic development. Curr. Med. Chem., 2019, 26, 1-16. Link
Mussie Gide, Alekhya Nimmagadda, Ma Su, Minghui Wang, Peng Teng, Chunpu Li, Ruixuan Gao, Hai Xu, Qi Li,* Jianfeng Cai*. Nano-Sized Lipidated Dendrimers as Potent and Broad Spectrum Antibacterial Agents, Macromol. Rapid Commun., 2018, 1800622, Link
Olapeju Bolarinwa, Meng Zhang, Erin Mulry, Min Lu* and Jianfeng Cai.* Sulfono-γ-AA modified peptides that inhibit HIV-1 fusion, Org. Biomol. Chem., 2018, 16, 7878-7882, Link
Fengyu She,+ Peng Teng,+ Alfredo Peguero-Tejada, Minghui Wang, Ning Ma, Timothy Odom, Mi Zhou, Erald Gjonaj, Lukasz Wojtas, Arjan van der Vaart, and Jianfeng Cai.* De novo Left-Handed Synthetic Peptidomimetic Foldamers, Angew. Chem. Int. Ed., 2018 , 9916-9920. Link
Jisong Hua, Peng Teng, Yingying Zou, Chao Zhang, Xujie Shen, Jianfeng Cai,* and Yong Hu.* Small Antimicrobial Agents encapsulated in poly(epsilon-caprolactone)-poly(ethylene glycol) nanoparticles for treatment of S. aureus -infected wounds, J. Nanopar. Res., 2018, 20, 1-14, Link
Olapeju Bolarinwa and Jianfeng Cai.* Developments with investigating descriptors for antimicrobial AApeptides and their derivatives., Exp. Opin. Drug. Discov., 2018 , 727-739. Link
Yong Liang, Jun Tang, Xiang Wang, Siqi Zhao, Ting Luo, Cijun Shuai,* Jinzhi Jiang, Jianfeng Cai,* and Hai Xu.* Using bispyrene fluorescence probe for determining the multiple states of organogel. Chemistryselect, 2018, 5361-5363. Link
Sylvia Singh, Alekhya Nimmagadda, Ma Su, Minghui Wang, Peng Teng, and Jianfeng Cai.* Lipidated α/α-AA heterogeneous peptides as antimicrobial agents, Eur. J. Med. Chem., 2018 , 398-405. Link
Peng Teng,+ Chunhui Li,+ Zhong Peng,+ Anne Marie Vanderschouw, Alekhya Nimmagadda, Ma Su, Yaqiong Li, Xingmin Sun,* and Jianfeng Cai.* Facilely Accessible Quinoline Derivatives as Potent Antibacterial Agents, Bioorg. Med. Chem., 2018 , 3573-3579. Link
Chunhui Li,+ Peng Teng,+ Zhong Peng,+ Peng Sang, Xingmin Sun,* and Jianfeng Cai.* Bis-Cyclic-Guanidine as a Novel Class of Compounds Potent Against Clostridium Difficile, ChemMedChem, 2018 , 1414-1420. Link
Heng Wang,+ Xiaomin Qian,+ Kun Wang, Ma Su, Wei-Wei Haoyang, Xin Jiang, Robert Brzozowski, Ming Wang, Xiang Gao, Yiming Li, Bingqian Xu, Prahathees Eswara, Xin-Qi Hao, Weitao Gong,* Jun-Li Hou,* Jianfeng Cai,* Xiaopeng Li,* Supramolecular Kandinsky circles with high antibacterial activity. Nat. Commun., 2018 , 9, 1815. Link
Peng Teng,+ Zheng Niu,+ Fengyu She, Mi Zhou, Peng Sang, Geoffrey M. Gray, Gaurav Verma, Lukasz Wojtas, Arjan van der Vaart, Shengqian Ma,* and Jianfeng Cai.* Hydrogen-Bonding-Driven 3D Supramolecular Assembly of Peptidomimetic Zipper, J. Am. Chem. Soc., 2018, 140, 17, 5661-5665. Link Cover
Youhong Niu,* Minghui Wang, Yafei Cao, Alekhya Nimmagadda, Jianxing Hu, Yanfen Wu, Jianfeng Cai,* and Xin-Shan Ye.* Rational Design of Dimeric Lysine N-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents, J. Med. Chem., 2018, 61, 7, 2865-2874, Link
Xiaojun Sun, Yuan Ren, Steven Gunawan, Peng Teng, Zhengming Chen, Harshani Lawrence, Jianfeng Cai, Nicholas Lawrence, and Jie Wu.* Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099, Leukemia, 2018, 32, 1246-1248,
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